MD2905G2 - Process for obtaining symmetrical N,N'-malonyl-bis-diamides of the aminobensoic acid esters - Google Patents

Process for obtaining symmetrical N,N'-malonyl-bis-diamides of the aminobensoic acid esters

Info

Publication number
MD2905G2
MD2905G2 MDA20040009A MD20040009A MD2905G2 MD 2905 G2 MD2905 G2 MD 2905G2 MD A20040009 A MDA20040009 A MD A20040009A MD 20040009 A MD20040009 A MD 20040009A MD 2905 G2 MD2905 G2 MD 2905G2
Authority
MD
Moldova
Prior art keywords
aminobensoic
diamides
malonyl
bis
acid esters
Prior art date
Application number
MDA20040009A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD20040009A (en
MD2905F2 (en
Inventor
Феликс ШЕПЕЛЬ
Флюр МАКАЕВ
Диана ШЕПЕЛЬ
Original Assignee
Институт Химии Академии Наук Молдовы
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт Химии Академии Наук Молдовы filed Critical Институт Химии Академии Наук Молдовы
Priority to MDA20040009A priority Critical patent/MD2905G2/en
Publication of MD20040009A publication Critical patent/MD20040009A/en
Publication of MD2905F2 publication Critical patent/MD2905F2/en
Publication of MD2905G2 publication Critical patent/MD2905G2/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to processes for obtaining pharmacologically active compounds used in the medical practice for treatment of cardiovascular diseases.The process for obtaining symmetrical N,N'-malonyl-bis-diamides of the aminobensoic acid esters includes condensation of the malonic ester with the aminobensoic acids esters, in the molar ratio of 1:2, in inert solvent at the temperature of 170…215°C.
MDA20040009A 2003-12-29 2003-12-29 Process for obtaining symmetrical N,N'-malonyl-bis-diamides of the aminobensoic acid esters MD2905G2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20040009A MD2905G2 (en) 2003-12-29 2003-12-29 Process for obtaining symmetrical N,N'-malonyl-bis-diamides of the aminobensoic acid esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20040009A MD2905G2 (en) 2003-12-29 2003-12-29 Process for obtaining symmetrical N,N'-malonyl-bis-diamides of the aminobensoic acid esters

Publications (3)

Publication Number Publication Date
MD20040009A MD20040009A (en) 2005-08-31
MD2905F2 MD2905F2 (en) 2005-11-30
MD2905G2 true MD2905G2 (en) 2006-07-31

Family

ID=34859145

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20040009A MD2905G2 (en) 2003-12-29 2003-12-29 Process for obtaining symmetrical N,N'-malonyl-bis-diamides of the aminobensoic acid esters

Country Status (1)

Country Link
MD (1) MD2905G2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU207236A1 (en) * Ф. Г. Шепель , Л. Б. Дашкевич METHOD FOR PRODUCING SODIUM OR POTASSIUM SALTS OF N, N'-MALOHYL-BI-AMIHOBENCHENIC ACIDS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU207236A1 (en) * Ф. Г. Шепель , Л. Б. Дашкевич METHOD FOR PRODUCING SODIUM OR POTASSIUM SALTS OF N, N'-MALOHYL-BI-AMIHOBENCHENIC ACIDS
SU195441A1 (en) * Ф. Г. Шепель , Н. К. Лисицина METHOD OF OBTAINING CHLORANGIDRID MALC NEVER ACID!

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Дашкевич Л.Б., Куваев Е.Н. ЖОХ, 1961, т. 31, N 5, с. 1669-1671 *
Заржевский Е.В. Автореф. к.м.н. Ленинград, 1991, с. 19 *
Мельникова Т.А., Рыжова А.Ф. Фармакология и химия. Ленинград, 1965, с. 207 *
Михайлов К.В. Автореф. к.м.н. С.-Петербург, 1993, с. 20 *
Шепель Ф.Г., Баев О.М., Дашкевич Л.Б. ЖПХ, 1996, т. 69, N 6, с. 987-998 *

Also Published As

Publication number Publication date
MD20040009A (en) 2005-08-31
MD2905F2 (en) 2005-11-30

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees