MD2851F1 - Inhibitor of human myeloid leukemia on base of asymmetric cobalt trichloroacetate dimer - Google Patents

Inhibitor of human myeloid leukemia on base of asymmetric cobalt trichloroacetate dimer

Info

Publication number
MD2851F1
MD2851F1 MDA20040199A MD20040199A MD2851F1 MD 2851 F1 MD2851 F1 MD 2851F1 MD A20040199 A MDA20040199 A MD A20040199A MD 20040199 A MD20040199 A MD 20040199A MD 2851 F1 MD2851 F1 MD 2851F1
Authority
MD
Moldova
Prior art keywords
aqua
cobalt
trichloroacetate
bis
inhibitor
Prior art date
Application number
MDA20040199A
Other languages
Romanian (ro)
Other versions
MD2851G2 (en
Inventor
Aurelian Gulea
Donald Poirier
Jenny Roy
Lilia Popovschi
Victor Tapcov
Original Assignee
Universitatea De Stat Din Moldova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitatea De Stat Din Moldova filed Critical Universitatea De Stat Din Moldova
Priority to MDA20040199A priority Critical patent/MD2851G2/en
Publication of MD2851F1 publication Critical patent/MD2851F1/en
Publication of MD2851G2 publication Critical patent/MD2851G2/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Inventia se refera la aplicarea combinatiilor coordinative in medicina si anume la utilizarea (m-aqua)-bis(m-tricloracetato)-tri(aqua)cobalt-aqua-bis(tricloracetato)cobalt monohidrat in calitate de inhibitor al leucemiei umane mieloide. Esenta inventiei consta in aceea ca in calitate de inhibitor al leucemiei umane mieloide se revendica (m-aqua)-bis(m-tricloracetato)-tri(aqua)cobalt-aqua-bis(tricloracetato)cobalt monohidrat cu formula :Rezultatul inventiei consta in stabilirea la cunoscutul (m-aqua)-bis(m-tricloracetato)-tri(aqua)cobalt-aqua-bis(tricloracetato)cobalt monohidrat a activitatii anticanceroase, care depaseste de 1,25...1,35 ori caracteristicile analoage ale dimerilor trihidratului aquaetilendiamintetraacetatobismutatului(III) de 1,6-dinitrotetraamincobalt(III) si dihidratului etilendiamintetraacetatobismutatului(III) de oxalatotetraamincobalt(III) (analogului).The invention relates to the application of coordinative combinations in medicine, namely to the use (m-aqua)-bis (m-trichloroacetate) -tri (aqua) cobalt-aqua-bis (trichloracetate) cobalt monohydrate as an inhibitor of human myeloid leukemia. The essence of the invention is that as a human myeloid leukemia inhibitor it is claimed (m-aqua) -bis (m-trichloroacetate) -tri (aqua) cobalt-aqua-bis (trichloracetate) cobalt monohydrate of the formula: The result of the invention consists in establishing at known (m-aqua)-bis (m-trichloroacetate) -thi (aqua) cobalt-aqua-bis (trichloracetate) cobalt monohydrate of the anticancer activity, which exceeds 1.25 ... 1.35 times the analogous characteristics of dimers of the 1,6-dinitrotetraamincobalt (III) aquaethylenediaminetetraacetate acetate (III) and the oxalatotetraamincobalt (III) ethylenediaminetetraacetate (III) dihydrate (analog).

MDA20040199A 2004-08-12 2004-08-12 Inhibitor of human myeloid leukemia on base of asymmetric cobalt trichloroacetate dimer MD2851G2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20040199A MD2851G2 (en) 2004-08-12 2004-08-12 Inhibitor of human myeloid leukemia on base of asymmetric cobalt trichloroacetate dimer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20040199A MD2851G2 (en) 2004-08-12 2004-08-12 Inhibitor of human myeloid leukemia on base of asymmetric cobalt trichloroacetate dimer

Publications (2)

Publication Number Publication Date
MD2851F1 true MD2851F1 (en) 2005-09-30
MD2851G2 MD2851G2 (en) 2006-04-30

Family

ID=35057542

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20040199A MD2851G2 (en) 2004-08-12 2004-08-12 Inhibitor of human myeloid leukemia on base of asymmetric cobalt trichloroacetate dimer

Country Status (1)

Country Link
MD (1) MD2851G2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3098G2 (en) * 2006-01-03 2007-02-28 Государственный Университет Молд0 Dihydrate of di( -Ophenoxy)-di[N-(2-oxy-1-benzal)-N1- -oxyfuralhydrazine(2-)copper] with properties of inhibitor of the human myeloid leukemia

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4215C1 (en) * 2012-07-09 2013-11-30 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD2786G2 (en) * 2004-05-11 2006-02-28 Государственный Университет Молд0 Inhibitors of human myeloid leukemia on base of heteronuclear coordinative compounds of cobalt(III) and bismuth(III)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3098G2 (en) * 2006-01-03 2007-02-28 Государственный Университет Молд0 Dihydrate of di( -Ophenoxy)-di[N-(2-oxy-1-benzal)-N1- -oxyfuralhydrazine(2-)copper] with properties of inhibitor of the human myeloid leukemia

Also Published As

Publication number Publication date
MD2851G2 (en) 2006-04-30

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Legal Events

Date Code Title Description
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees