MD21C2 - Способ получения 22(R,S)-11б 21-дигидрокси-16 17-бутилиденбисоксипрегна-1б4-диен-3б20-диона - Google Patents

Способ получения 22(R,S)-11б 21-дигидрокси-16 17-бутилиденбисоксипрегна-1б4-диен-3б20-диона

Info

Publication number
MD21C2
MD21C2 MD94-0086A MD940086A MD21C2 MD 21 C2 MD21 C2 MD 21C2 MD 940086 A MD940086 A MD 940086A MD 21 C2 MD21 C2 MD 21C2
Authority
MD
Moldova
Prior art keywords
dion
dien
butylidenbisoxipregn
dihidroxi
obtaining
Prior art date
Application number
MD94-0086A
Other languages
English (en)
Romanian (ro)
Other versions
MD21B1 (ro
Inventor
Gyordy Hajos Dr.
Molnar Csaba
Jozsef Toth Dr.
Arpad Kiraly Dr.
Gyorgy Fekete Dr.
Laszlo Szporny Dr.
Lilla Fordacs Dr.
Boor Nee Mezei Anna
Major nee Forstner Piroska
Herenyi Bulcsu
Original Assignee
Richter Gedeon Vegyeszeti Gyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SU884355323A external-priority patent/SU1711675A3/ru
Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.
Priority to MD940086A priority Critical patent/MD21B1/xx
Publication of MD21C2 publication Critical patent/MD21C2/ru
Publication of MD21B1 publication Critical patent/MD21B1/xx

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  • Steroid Compounds (AREA)

Abstract

Изобретение касается стероидов, в частности получения 22(R,S)-11b, 21-дигидрокси-16a, 17-бутилиденбисоксипрегнат-1,4-диен-3,20-диона, обладающего фарамкологическим действием на живой организм. Цель - создание способа получения указанного продукта с желаемым соотношением изомеров. Синтез ведут реакцией 11b, 16a, 17-тригидрокси-21-ацетокси-прегна-1,4-диен-3,20-дион-16,17-метиловый эфир, циклооптомуравьиной кислоты с н-бутиральальдегидом при молярном соотношении 1:2, в среде тетрагидрофурана в присутствии уксусного ангидрида при комнатной температуре с последующим омылением полученного продукта в присутствии перхлорной кислоты. В этом случае получают целевой продукт с соотношением 22R:S изомеров 1:1, чистотой до 96%.
MD940086A 1988-02-29 1994-02-25 Metoda de obtinere a 22(r,s) 11beta, 21-dihidroxi-16alpha, 17-butilidenbisoxipregn-1,4-dien-3,20 dionului MD21B1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MD940086A MD21B1 (ro) 1988-02-29 1994-02-25 Metoda de obtinere a 22(r,s) 11beta, 21-dihidroxi-16alpha, 17-butilidenbisoxipregn-1,4-dien-3,20 dionului

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SU884355323A SU1711675A3 (ru) 1988-02-26 1988-02-29 Способ получени 22 /R, S/-11 @ , 21 - дигидрокси-16 @ , 17-бутилиденбисоксипрегна - 1,4-диен-3,20-диона
MD940086A MD21B1 (ro) 1988-02-29 1994-02-25 Metoda de obtinere a 22(r,s) 11beta, 21-dihidroxi-16alpha, 17-butilidenbisoxipregn-1,4-dien-3,20 dionului

Publications (2)

Publication Number Publication Date
MD21C2 true MD21C2 (ru) 1994-05-31
MD21B1 MD21B1 (ro) 1994-05-31

Family

ID=21346945

Family Applications (1)

Application Number Title Priority Date Filing Date
MD940086A MD21B1 (ro) 1988-02-29 1994-02-25 Metoda de obtinere a 22(r,s) 11beta, 21-dihidroxi-16alpha, 17-butilidenbisoxipregn-1,4-dien-3,20 dionului

Country Status (3)

Country Link
LT (1) LT2202B (ru)
LV (1) LV5274A3 (ru)
MD (1) MD21B1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD320Z (ru) * 2010-05-24 2011-08-31 Государственный Университет Молд0 Установка для регенерации картриджа с активированным углем или с минеральными сорбентами, используемого для очистки воды от органических соединений

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037914A (en) * 1960-05-06 1962-06-05 American Cyanamid Co Bacterial production of triamcinolone by bacterial formulations
DE2323215A1 (de) * 1972-05-19 1973-11-29 Bofors Ab Steroide, verfahren zu deren herstellung und sie enthaltende arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037914A (en) * 1960-05-06 1962-06-05 American Cyanamid Co Bacterial production of triamcinolone by bacterial formulations
DE2323215A1 (de) * 1972-05-19 1973-11-29 Bofors Ab Steroide, verfahren zu deren herstellung und sie enthaltende arzneimittel

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J.A.C.S., 1956, 78, 909. *
J.A.C.S., 1958, 80, 2338. *
J.A.C.S., 1959, 81, 1689. *
Thalen A. and R. Brattsand. Synthesls and Antilflmmatory Properties of Budesondle. A new: Non-halogenated Nucocorticold with High Local Activity-Arznel Forschung, 1979, 29(11), 1887. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD320Z (ru) * 2010-05-24 2011-08-31 Государственный Университет Молд0 Установка для регенерации картриджа с активированным углем или с минеральными сорбентами, используемого для очистки воды от органических соединений

Also Published As

Publication number Publication date
MD21B1 (ro) 1994-05-31
LT2202B (lt) 1993-10-15
LV5274A3 (lv) 1993-10-10

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