MD21C2 - Metodă de obţinere a 22(R,S)-11, 21-dihidroxi-16, 17-butilidenbisoxipregn-1,4-dien-3, 20-dionului - Google Patents

Metodă de obţinere a 22(R,S)-11, 21-dihidroxi-16, 17-butilidenbisoxipregn-1,4-dien-3, 20-dionului

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Publication number
MD21C2
MD21C2 MD94-0086A MD940086A MD21C2 MD 21 C2 MD21 C2 MD 21C2 MD 940086 A MD940086 A MD 940086A MD 21 C2 MD21 C2 MD 21C2
Authority
MD
Moldova
Prior art keywords
dion
dien
butylidenbisoxipregn
dihidroxi
obtaining
Prior art date
Application number
MD94-0086A
Other languages
English (en)
Russian (ru)
Other versions
MD21B1 (ro
Inventor
Gyordy Hajos Dr.
Molnar Csaba
Jozsef Toth Dr.
Arpad Kiraly Dr.
Gyorgy Fekete Dr.
Laszlo Szporny Dr.
Lilla Fordacs Dr.
Boor Nee Mezei Anna
Major nee Forstner Piroska
Herenyi Bulcsu
Original Assignee
Richter Gedeon Vegyeszeti Gyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SU884355323A external-priority patent/SU1711675A3/ru
Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.
Priority to MD940086A priority Critical patent/MD21B1/ro
Publication of MD21C2 publication Critical patent/MD21C2/ro
Publication of MD21B1 publication Critical patent/MD21B1/ro

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  • Steroid Compounds (AREA)

Abstract

Invenţia se referă la steroide, în particular la obţinerea “”(R, S)-11β, 21-dihidroxi-16α, 17-bitilidenbisoxipregn-1,4-dien-3,20-dionului ce care o acţiune farmacologică asupra organismului. Scopul constă în crearea unei metodei de obţinere a produsului indicat cu un raport dorit al izomerilor. Sinteza se face prin reacţia 11β, 16α, 17-trihidroxi-21, cetoxipregn-1,4-dien-3,20-dion-16,17-eterului metilic al acidului cicloortoformic cu n-buteraldehidă, având raportul molar 1:2, în mediul tetrahidrofuranului în prezenţa anhidridei acetice la temperatură de cameră, saponificând ulterior produsul obţinut în prezenţa acidului percloric. În acest caz se obţine un produs căutat cu raportul 22R:S al zomerilor 1:1 puritatea până la 96%.
MD940086A 1988-02-29 1994-02-25 Metoda de obtinere a 22(r,s) 11beta, 21-dihidroxi-16alpha, 17-butilidenbisoxipregn-1,4-dien-3,20 dionului MD21B1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MD940086A MD21B1 (ro) 1988-02-29 1994-02-25 Metoda de obtinere a 22(r,s) 11beta, 21-dihidroxi-16alpha, 17-butilidenbisoxipregn-1,4-dien-3,20 dionului

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SU884355323A SU1711675A3 (ru) 1988-02-26 1988-02-29 Способ получени 22 /R, S/-11 @ , 21 - дигидрокси-16 @ , 17-бутилиденбисоксипрегна - 1,4-диен-3,20-диона
MD940086A MD21B1 (ro) 1988-02-29 1994-02-25 Metoda de obtinere a 22(r,s) 11beta, 21-dihidroxi-16alpha, 17-butilidenbisoxipregn-1,4-dien-3,20 dionului

Publications (2)

Publication Number Publication Date
MD21C2 true MD21C2 (ro) 1994-05-31
MD21B1 MD21B1 (ro) 1994-05-31

Family

ID=21346945

Family Applications (1)

Application Number Title Priority Date Filing Date
MD940086A MD21B1 (ro) 1988-02-29 1994-02-25 Metoda de obtinere a 22(r,s) 11beta, 21-dihidroxi-16alpha, 17-butilidenbisoxipregn-1,4-dien-3,20 dionului

Country Status (3)

Country Link
LT (1) LT2202B (ro)
LV (1) LV5274A3 (ro)
MD (1) MD21B1 (ro)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD320Z (ro) * 2010-05-24 2011-08-31 Государственный Университет Молд0 Instalaţie pentru regenerarea cartuşului cu cărbune activ sau cu absorbanţi minerali, utilizat pentru epurarea apei de compuşi organici

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037914A (en) * 1960-05-06 1962-06-05 American Cyanamid Co Bacterial production of triamcinolone by bacterial formulations
DE2323215A1 (de) * 1972-05-19 1973-11-29 Bofors Ab Steroide, verfahren zu deren herstellung und sie enthaltende arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037914A (en) * 1960-05-06 1962-06-05 American Cyanamid Co Bacterial production of triamcinolone by bacterial formulations
DE2323215A1 (de) * 1972-05-19 1973-11-29 Bofors Ab Steroide, verfahren zu deren herstellung und sie enthaltende arzneimittel

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J.A.C.S., 1956, 78, 909. *
J.A.C.S., 1958, 80, 2338. *
J.A.C.S., 1959, 81, 1689. *
Thalen A. and R. Brattsand. Synthesls and Antilflmmatory Properties of Budesondle. A new: Non-halogenated Nucocorticold with High Local Activity-Arznel Forschung, 1979, 29(11), 1887. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD320Z (ro) * 2010-05-24 2011-08-31 Государственный Университет Молд0 Instalaţie pentru regenerarea cartuşului cu cărbune activ sau cu absorbanţi minerali, utilizat pentru epurarea apei de compuşi organici

Also Published As

Publication number Publication date
MD21B1 (ro) 1994-05-31
LT2202B (lt) 1993-10-15
LV5274A3 (lv) 1993-10-10

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