MD21C2 - The method of obtaining 22(R,S)-11b, 21-dihidroxi-16a, 17 butylidenbisoxipregn-1,4-dien-3,20 dion - Google Patents

The method of obtaining 22(R,S)-11b, 21-dihidroxi-16a, 17 butylidenbisoxipregn-1,4-dien-3,20 dion

Info

Publication number
MD21C2
MD21C2 MD94-0086A MD940086A MD21C2 MD 21 C2 MD21 C2 MD 21C2 MD 940086 A MD940086 A MD 940086A MD 21 C2 MD21 C2 MD 21C2
Authority
MD
Moldova
Prior art keywords
dion
dien
butylidenbisoxipregn
dihidroxi
obtaining
Prior art date
Application number
MD94-0086A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD21B1 (en
Inventor
Gyordy Hajos Dr.
Molnar Csaba
Jozsef Toth Dr.
Arpad Kiraly Dr.
Gyorgy Fekete Dr.
Laszlo Szporny Dr.
Lilla Fordacs Dr.
Boor Nee Mezei Anna
Major nee Forstner Piroska
Herenyi Bulcsu
Original Assignee
Richter Gedeon Vegyeszeti Gyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SU884355323A external-priority patent/SU1711675A3/en
Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.
Priority to MD940086A priority Critical patent/MD21B1/en
Publication of MD21C2 publication Critical patent/MD21C2/en
Publication of MD21B1 publication Critical patent/MD21B1/en

Links

Landscapes

  • Steroid Compounds (AREA)

Abstract

The invention relates to the steroids particularly to obtaining 22(R,S)-11β, 21-dihidroxi-16a, 17 butylidenbisoxipregn-1,4-dien-3,20 dion which has a pharmacological action on organism. The goal of the invention is to obtain this product with a desired isomer ratio. The synthesis is made by reaction 11β, 16a, 17-trihydroxi-21 acetoxi-pregn-1,4-dien-3,20-dion 16,17-ether metilyc of cicloortobornic acid with n-butiraldehyde, the molar ratio is 1:2, in the tetrahydrofuran medium in the presence of anhydride acetic at room temperature, saponifing the obtained product in the presence of perchloric acid. In this case a product is obtained with the isomer ratio 22R:S 1:1 with purity up to 96%.
MD940086A 1988-02-29 1994-02-25 Method for obtaining 22 (r, s) 11beta, 21-dihydroxy-16alpha, 17-butylidenbisoxypregn-1,4-diene-3,20 dione MD21B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MD940086A MD21B1 (en) 1988-02-29 1994-02-25 Method for obtaining 22 (r, s) 11beta, 21-dihydroxy-16alpha, 17-butylidenbisoxypregn-1,4-diene-3,20 dione

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SU884355323A SU1711675A3 (en) 1988-02-26 1988-02-29 Method of 22(r,s)-11@@@,21-dihydroxy-16@@@,17-butylidene-bis- oxypregna-1,4-d- iene-3,20-dione synthesis
MD940086A MD21B1 (en) 1988-02-29 1994-02-25 Method for obtaining 22 (r, s) 11beta, 21-dihydroxy-16alpha, 17-butylidenbisoxypregn-1,4-diene-3,20 dione

Publications (2)

Publication Number Publication Date
MD21C2 true MD21C2 (en) 1994-05-31
MD21B1 MD21B1 (en) 1994-05-31

Family

ID=21346945

Family Applications (1)

Application Number Title Priority Date Filing Date
MD940086A MD21B1 (en) 1988-02-29 1994-02-25 Method for obtaining 22 (r, s) 11beta, 21-dihydroxy-16alpha, 17-butylidenbisoxypregn-1,4-diene-3,20 dione

Country Status (3)

Country Link
LT (1) LT2202B (en)
LV (1) LV5274A3 (en)
MD (1) MD21B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD320Z (en) * 2010-05-24 2011-08-31 Государственный Университет Молд0 Installation for the regeneration of cartridge with activated carbon or mineral sorbents used for purification of water from organic compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037914A (en) * 1960-05-06 1962-06-05 American Cyanamid Co Bacterial production of triamcinolone by bacterial formulations
DE2323215A1 (en) * 1972-05-19 1973-11-29 Bofors Ab STEROIDS, THE METHOD OF MANUFACTURING THEREOF AND MEDICINAL PRODUCTS CONTAINING THEM

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037914A (en) * 1960-05-06 1962-06-05 American Cyanamid Co Bacterial production of triamcinolone by bacterial formulations
DE2323215A1 (en) * 1972-05-19 1973-11-29 Bofors Ab STEROIDS, THE METHOD OF MANUFACTURING THEREOF AND MEDICINAL PRODUCTS CONTAINING THEM

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J.A.C.S., 1956, 78, 909. *
J.A.C.S., 1958, 80, 2338. *
J.A.C.S., 1959, 81, 1689. *
Thalen A. and R. Brattsand. Synthesls and Antilflmmatory Properties of Budesondle. A new: Non-halogenated Nucocorticold with High Local Activity-Arznel Forschung, 1979, 29(11), 1887. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD320Z (en) * 2010-05-24 2011-08-31 Государственный Университет Молд0 Installation for the regeneration of cartridge with activated carbon or mineral sorbents used for purification of water from organic compounds

Also Published As

Publication number Publication date
LT2202B (en) 1993-10-15
LV5274A3 (en) 1993-10-10
MD21B1 (en) 1994-05-31

Similar Documents

Publication Publication Date Title
AU6530990A (en) Process for the manufacture of budesonide
CA2083041A1 (en) Labeled compounds for use in a diagnostic breath test
ES8707516A1 (en) PROCESS FOR THE PRODUCTION OF -i(GAMMA)-BUTYROLACTONE.
CA2019830A1 (en) Method of producing symmetrical difatty acid diamides
MD21C2 (en) The method of obtaining 22(R,S)-11b, 21-dihidroxi-16a, 17 butylidenbisoxipregn-1,4-dien-3,20 dion
US4213902A (en) Process for producing steroidal 7α-acylthio-4-en-3-ones
US3313809A (en) Steroido[21, 20-d]isoxazoles
PL255391A1 (en) Method of obtaining pregnane derivatives
AU1028588A (en) Novel crystalline cefadroxil and method for producing it
US4102907A (en) Desulfinylation process for preparing androsta-4,9(11)-diene-3,17-dione
US4031080A (en) 16-Alpha-methyl-17 alpha-bromo-1,4-pregnadiene-21-ol-3,20-dione-derivatives
AU7108491A (en) Improved process for synthesis of 5alpha-cholest-8(14)-en- 3beta-ol-15-one and other 15-oxygenated sterols
EP0534800A3 (en) Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammatory agents
IE860879L (en) 16,17-acetalsubstituted androstane-17-beta-carboxylic acid¹esters
DE3563433D1 (en) Process for the production of acetic acid from synthesis gas
IE890128L (en) Method of producing 2-substituted oximino-3-oxobutyric¹acids.
EP0264168A3 (en) Process for producing 6-hydroxy-2-naphthones
JPS6466137A (en) Production of (+)-5s-isopropyl-8-methyl-6e,8-nonadien-2-one
US4097477A (en) Steroid compounds and processes thereof
US3000883A (en) Preparation of 17alpha-hydroxyprogesterone and intermediates
CA2051397A1 (en) Oxidative preparation of 3,5-secoandrost-5-one-3,17.beta.-dioic acid
GB1050218A (en)
JPS6468389A (en) Novel n-acetyl-beta-d-glucosamine derivative
HUT49120A (en) Process for producing 16-methoxy-16-methyl-prostaglandin el derivative and its intermediate
Lancaster Synthesis of Bisimides

Legal Events

Date Code Title Description
1M4A Expiration of terms