MD1138Z - Method for treating chronic adnexitis - Google Patents
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- MD1138Z MD1138Z MDS20160088A MDS20160088A MD1138Z MD 1138 Z MD1138 Z MD 1138Z MD S20160088 A MDS20160088 A MD S20160088A MD S20160088 A MDS20160088 A MD S20160088A MD 1138 Z MD1138 Z MD 1138Z
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- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 title claims abstract description 6
- 206010049677 Salpingo-oophoritis Diseases 0.000 title claims abstract description 6
- 230000001684 chronic effect Effects 0.000 title claims abstract description 5
- 238000000034 method Methods 0.000 title claims description 12
- 239000000203 mixture Substances 0.000 claims abstract description 13
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 10
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 10
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims abstract description 5
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 5
- 229940046009 vitamin E Drugs 0.000 claims abstract description 5
- 239000011709 vitamin E Substances 0.000 claims abstract description 5
- 239000011787 zinc oxide Substances 0.000 claims abstract description 5
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000012054 meals Nutrition 0.000 claims abstract description 4
- 210000005059 placental tissue Anatomy 0.000 claims abstract description 4
- 238000001802 infusion Methods 0.000 claims description 9
- 241000736851 Tagetes Species 0.000 claims description 8
- 235000005881 Calendula officinalis Nutrition 0.000 claims description 6
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 abstract description 3
- 241000132025 Calendula Species 0.000 abstract description 3
- 235000003880 Calendula Nutrition 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- 229940098465 tincture Drugs 0.000 abstract 2
- 210000001136 chorion Anatomy 0.000 description 7
- 210000003954 umbilical cord Anatomy 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 210000003717 douglas' pouch Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 235000012308 Tagetes Nutrition 0.000 description 2
- 230000003308 immunostimulating effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000003101 oviduct Anatomy 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- 206010000084 Abdominal pain lower Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 229920000715 Mucilage Polymers 0.000 description 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 229930185210 Saponoside Natural products 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 208000032159 Vaginal inflammation Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000020680 filtered tap water Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940100243 oleanolic acid Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 210000000685 uterine artery Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
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Abstract
Description
Invenţia se referă la medicină, în special la ginecologie şi poate fi utilizată pentru tratamentul anexitei cronice. The invention relates to medicine, in particular to gynecology and can be used for the treatment of chronic adnexitis.
Este cunoscută metoda de tratament al anexitei cronice, care constă în aceea că în vagin se introduc 3…5 ml de soluţie uleioasă de 1% de eplir şi se efectuează vibromasaj intravaginal cu scăderea treptată a frecvenţei 98...102, 66...68 şi 48...52 Hz, timp de 2…3 min pentru fiecare etapă, durata procedurii constituie 6…9 min, seria de tratament constituie 8…10 proceduri [1]. There is a known method of treating chronic adnexitis, which consists in introducing 3…5 ml of 1% oil solution of eplir into the vagina and performing intravaginal vibromassage with a gradual decrease in frequency to 98…102, 66…68 and 48…52 Hz, for 2…3 min for each stage, the duration of the procedure is 6…9 min, the treatment series is 8…10 procedures [1].
Dezavantajul acestei metode constă în aceea că se dezvoltă un efect terapeutic neînsemnat şi necesită repetarea seriei de tratament peste fiecare 30 de zile. The disadvantage of this method is that it develops an insignificant therapeutic effect and requires repeating the treatment series every 30 days.
Problema pe care o soluţionează invenţia propusă constă în sporirea eficienţei tratamentului cu efect antiinflamator şi imunostimulator evidenţiat. The problem solved by the proposed invention consists in increasing the efficiency of the treatment with a pronounced anti-inflammatory and immunostimulatory effect.
Esenţa invenţiei constă în aceea că se efectuează spălături vaginale o dată pe zi cu un amestec, ce conţine infuzie de gălbenele, soluţie de vitamina E de 30%, în raport de 8:1, şi ozon cu concentraţia de 6000...10000 µg/L, totodată per os se administrează un amestec obţinut din ţesut de placentă umană denaturat şi infuzie de gălbenele, în raport de 1:2, omogenizat şi filtrat, cu un adaos de pulbere de nanoparticule de oxid de zinc şi argint, în raport de 9:1, 5 mg la 100 ml de amestec, totodată amestecul se administrează câte 100 ml de 3 ori pe zi, cu 30 min înainte de masă, timp de 12 zile. The essence of the invention consists in performing vaginal douches once a day with a mixture containing marigold infusion, 30% vitamin E solution, in a ratio of 8:1, and ozone with a concentration of 6000...10000 µg/L, at the same time, a mixture obtained from denatured human placenta tissue and marigold infusion, in a ratio of 1:2, homogenized and filtered, with an addition of zinc oxide and silver nanoparticles powder, in a ratio of 9:1, 5 mg per 100 ml of the mixture, at the same time, the mixture is administered 100 ml 3 times a day, 30 min before meals, for 12 days.
Rezultatul tehnic constă în obţinerea unui efect antiinflamator şi imunostimulator evidenţiat, datorită atât a combinării calitative şi cantitative reuşite a ingredientelor administrate, cât şi a modului de administrare a acestor ingrediente. The technical result consists in obtaining a marked anti-inflammatory and immunostimulatory effect, due to both the successful qualitative and quantitative combination of the administered ingredients, as well as the method of administration of these ingredients.
Avantajul metodei revendicate constă în sporirea efectului terapeutic, şi anume semnele clinice ale anexitei dispar deja la a 6-a zi, iar peste 12 zile se observă o însănătoşire definitivă cu dispariţia tuturor semnelor clinice şi o îmbunătăţire a datelor de laborator, recidive nu s-au atestat pe parcursul unui an de la finele tratamentului, totodată stimulând sistemul imunitar efectul antiinflamator se manifestă deja la a 3-a zi de la începutul tratamentului. The advantage of the claimed method lies in the increased therapeutic effect, namely the clinical signs of adnexitis disappear already on the 6th day, and after 12 days a definitive recovery is observed with the disappearance of all clinical signs and an improvement in laboratory data, relapses have not been observed during a year from the end of treatment, while stimulating the immune system, the anti-inflammatory effect is manifested already on the 3rd day from the beginning of treatment.
Modul de preparare a soluţiei pentru administrare orală include mai întâi prepararea soluţiei de ţesut de placentă umană în modul următor: se separă placenta de uter, se decupează cordonul ombilical şi corionul, apoi cordonul ombilical se dispensează de vasele sangvine, corionul se desparte în neted şi vilos, acest procedeu se efectuează mecanic în laborator. Apoi cordonul ombilical, corionul neted şi cel vilos preventiv se mărunţesc şi se spală cu apă de robinet filtrată peste fiecare 4 ore, timp de 12 ore până la hemoliza definitivă, se denaturează toate componentele, separat, cu soluţie de clor de 0,2% pe bază de clorură de sodiu, iar corionul vilos cu soluţie de clor de 0,4% la fel pe bază de clorură de sodiu, în raport de 1:5, durata denaturării 5 zile, apoi soluţiile de clor se varsă, produsele denaturate de cordon ombilical, de corion neted şi vilos, în raport de 1:4, se introduc în apă distilată ajustând soluţia până la pH-ul de 3,0 (Червяков Д. К и др. Лекарственные средства в ветеринарии. Справочник, Москва, Колос, 1977, стр. 261, 274-278). După care apa se varsă, cordonul ombilical şi corionul neted se mărunţesc grosier şi se amestecă cu corionul vilos, se dispersează până la dimensiunile particulelor de cel mult 0,4 mm, se diluează cu infuzie de gălbenele în proporţie de 1:2, se malaxează până la omogenizarea soluţiei, se filtrează, apoi la 100 ml de soluţie obţinută se adaugă 5 mg de nanoparticule de oxid de zinc şi argint sub formă de pulbere, în raport de 9:1, se amestecă timp de 10 min şi se utilizează per os, câte 100 ml de 3 ori pe zi, cu 30 min înainte de masă, timp de 12 zile. The method of preparing the solution for oral administration first includes preparing the human placenta tissue solution in the following way: the placenta is separated from the uterus, the umbilical cord and chorion are cut, then the umbilical cord is freed from blood vessels, the chorion is separated into smooth and villous, this process is performed mechanically in the laboratory. Then the umbilical cord, smooth and villous chorion are chopped and washed with filtered tap water every 4 hours for 12 hours until definitive hemolysis, all components are denatured separately with 0.2% chlorine solution based on sodium chloride, and the villous chorion with 0.4% chlorine solution also based on sodium chloride, in a ratio of 1:5, the duration of denaturation is 5 days, then the chlorine solutions are poured, the denatured products of the umbilical cord, smooth and villous chorion, in a ratio of 1:4, are introduced into distilled water, adjusting the solution to a pH of 3.0 (Червяков D. K. and others. Лекарственные средства в ветериании. Справочник, Москва, Колос, 1977, pp. 261, 274-278). After the water is poured out, the umbilical cord and smooth chorion are coarsely chopped and mixed with the villous chorion, dispersed to particle sizes of no more than 0.4 mm, diluted with marigold infusion in a ratio of 1:2, kneaded until the solution is homogenized, filtered, then to 100 ml of the resulting solution, 5 mg of zinc oxide and silver nanoparticles in powder form are added, in a ratio of 9:1, mixed for 10 min and used orally, 100 ml 3 times a day, 30 min before meals, for 12 days.
Modul de preparare a soluţiei pentru spălături vaginale: într-un vas de 10 L se toarnă 8,0 L infuzie de gălbenele, se adaugă soluţie de vitamina E de 30% în cantitate de 1,0 L, după care soluţia se amestecă până la omogenizare, ulterior se ozonează până la un conţinut de 6000…10000 µg/L de ozon. How to prepare the solution for vaginal washes: pour 8.0 L of marigold infusion into a 10 L vessel, add 1.0 L of 30% vitamin E solution, after which the solution is mixed until homogenous, then ozonized to a content of 6000…10000 µg/L of ozone.
Din punct de vedere chimic gălbenelele conţin flavonoizi, ulei volatil, vitamina C, mucilagii, saponozide triterpenice, alcaloizi, substanţe carotenoide, (care dau culoarea galbenă), substanţe amare, acid oleanolic şi au un gust amar. Datorită compoziţiei chimice pe care o au gălbenelele, infuzia devine compatibilă cu vitamina E de 30%. Chemically, marigolds contain flavonoids, volatile oil, vitamin C, mucilages, triterpene saponosides, alkaloids, carotenoid substances (which give the yellow color), bitter substances, oleanolic acid and have a bitter taste. Due to the chemical composition of marigolds, the infusion becomes compatible with 30% vitamin E.
Infuzia de gălbenele se prepară în felul următor: la 1 parte de masă vegetală se adaugă 3 părţi de apă clocotită, se răceşte până la temperatura camerei şi se filtrează, în aşa mod infuzia este gata pentru utilizare. Calendula infusion is prepared as follows: to 1 part of vegetable mass, add 3 parts of boiling water, cool to room temperature and filter, this way the infusion is ready for use.
Nanoparticulele de oxid de zinc şi argint sub formă de pulbere, luate în raport masic de 9:1, se obţin conform brevetului RU 2451578 C1 2012.05.27. Zinc oxide and silver nanoparticles in powder form, taken in a mass ratio of 9:1, are obtained according to patent RU 2451578 C1 2012.05.27.
Exemplu concret de realizare Concrete example of achievement
Pacienta A., în vârstă de 26 ani, s-a adresat cu acuze de dureri abdominale, inferioare, moderate, către finalul perioadei menstruale, febră 37...38°C, sângerări vaginale neregulate cu miros neplăcut. Anterior pacienta a urmat tratament ambulatoriu cu antibiotice, regenerative local, s-au făcut spălături cu soluţie uleioasă de 1% de eplir şi masaj intravaginal, timp de 10 zile, iar peste 1,5 luni tabloul clinic a revenit. Pacienta a fost investigată clinic şi paraclinic. Obiectiv s-a depistat hiperemie a vaginului, eliminări galbene-verzui, la ultrasonografie (USG), în spaţiul Douglas s-au depistat 120 ml de lichid. La doplerografie s-a depistat rezistenţă moderată a arterei şi venei uterine, trompele umplute cu lichid, Ig G a constituit 660 mg/dl. Pacientei i s-a propus să urmeze o cură de tratament conform metodei revendicate. După 3 zile de tratament, obiectiv a dispărut inflamaţia vaginală şi eliminările, la a 6-a zi au dispărut semnele clinice, iar la a 12-a zi de tratament la USG în spaţiul Douglas s-au depistat 80 ml de lichid, trompele uterine libere, la doplerografie - a dispărut rezistenţa arterială şi venoasă, iar Ig G a constituit 720 mg/dl, deci s-a constatat o creştere a Ig G, s-a diminuat cantitatea de lichid din spaţiul Douglas cu 40 ml, la doplerografie - a dispărut rezistenţa arterială şi venoasă, ceea ce denotă un efect imunomodulator atestat. Patient A., 26 years old, complained of moderate lower abdominal pain towards the end of her menstrual period, fever 37...38°C, irregular vaginal bleeding with an unpleasant odor. Previously, the patient had undergone outpatient treatment with antibiotics, local regenerative agents, douching with 1% oily solution of eplir and intravaginal massage for 10 days, and after 1.5 months the clinical picture returned. The patient was investigated clinically and paraclinically. Objectively, hyperemia of the vagina, yellow-green discharge were detected, ultrasonography (USG) revealed 120 ml of fluid in the Douglas space. Dopplerography revealed moderate resistance of the uterine artery and vein, the fallopian tubes were filled with fluid, Ig G was 660 mg/dl. The patient was proposed to undergo a course of treatment according to the claimed method. After 3 days of treatment, objectively, the vaginal inflammation and discharge disappeared, on the 6th day the clinical signs disappeared, and on the 12th day of treatment, USG detected 80 ml of fluid in the Douglas space, the fallopian tubes were free, on Dopplerography - the arterial and venous resistance disappeared, and Ig G was 720 mg/dl, so an increase in Ig G was found, the amount of fluid in the Douglas space decreased by 40 ml, on Dopplerography - the arterial and venous resistance disappeared, which denotes a certified immunomodulatory effect.
Metoda revendicată a fost aplicată pe un lot de 17 femei cu vârsta de la 19 la 32 ani, pe perioada tratamentului şi pe parcursul unui an după tratament recidive nu au fost depistate. The claimed method was applied to a group of 17 women aged 19 to 32 years, during the treatment period and one year after treatment, no relapses were detected.
1. RU 2211019 C1 2003.08.27 1. RU 2211019 C1 2003.08.27
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| MDS20160088A MD1138Z (en) | 2016-07-04 | 2016-07-04 | Method for treating chronic adnexitis |
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| Application Number | Priority Date | Filing Date | Title |
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| MDS20160088A MD1138Z (en) | 2016-07-04 | 2016-07-04 | Method for treating chronic adnexitis |
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| MD1138Y MD1138Y (en) | 2017-04-30 |
| MD1138Z true MD1138Z (en) | 2017-11-30 |
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Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU625715A1 (en) * | 1976-06-18 | 1978-09-30 | Тбилисский Государственный Медицинский Институт | Method of treating inflammatory diseases of female genital organs |
| SU862958A1 (en) * | 1977-01-17 | 1981-09-15 | Ставропольский политехнический институт | Method of treating inflammatory disease of female genital organs |
| SU1351610A1 (en) * | 1980-12-26 | 1987-11-15 | Всесоюзный Научно-Исследовательский Институт Медицинского Приборостроения | Method of treatment of chronic inflammatory diseases of genital organs in case of genital infantilism |
| SU1421351A1 (en) * | 1985-07-01 | 1988-09-07 | Томский научно-исследовательский институт курортологии и физиотерапии | Method of treatment of inflammatory diseases of the female internal genital organs in subacute stage |
| SU1438770A1 (en) * | 1985-10-31 | 1988-11-23 | Белорусский научно-исследовательский институт охраны материнства и детства | Method of treatment of inflammatory diseases of the female internal genital organs |
| SU1514384A1 (en) * | 1987-05-28 | 1989-10-15 | Volg G Med I | Method of treatment of acute inflammatory diseases of internal female genital organs |
| SU1708315A1 (en) * | 1989-02-13 | 1992-01-30 | Киевский государственный институт усовершенствования врачей | Method for treating chronic diseases of female genital organs |
| SU1747084A1 (en) * | 1989-10-02 | 1992-07-15 | Кубанский медицинский институт им.Красной Армии | Method for treating the diseases of female genital organs |
| SU1761144A1 (en) * | 1989-08-07 | 1992-09-15 | Томский Медицинский Институт | Method for treating acute inflammatory diseases of the female genital organs |
| MD1119G2 (en) * | 1998-06-22 | 1999-07-31 | Георге КУШНИР | Method for female genitals inflammatory diseases treatment |
| RU2211019C1 (en) * | 2002-07-17 | 2003-08-27 | Томский научно-исследовательский институт курортологии и физиотерапии | Method for treating chronic adnexitis |
| MD3646G2 (en) * | 2007-06-08 | 2009-02-28 | Общественное Медико-Санитарное Учреждение Научно-Исследовательский Институт В Области Охраны Матери И Ребенка | Method of treating chronic inflammatory diseases of female genital organs |
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2016
- 2016-07-04 MD MDS20160088A patent/MD1138Z/en not_active IP Right Cessation
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU625715A1 (en) * | 1976-06-18 | 1978-09-30 | Тбилисский Государственный Медицинский Институт | Method of treating inflammatory diseases of female genital organs |
| SU862958A1 (en) * | 1977-01-17 | 1981-09-15 | Ставропольский политехнический институт | Method of treating inflammatory disease of female genital organs |
| SU1351610A1 (en) * | 1980-12-26 | 1987-11-15 | Всесоюзный Научно-Исследовательский Институт Медицинского Приборостроения | Method of treatment of chronic inflammatory diseases of genital organs in case of genital infantilism |
| SU1421351A1 (en) * | 1985-07-01 | 1988-09-07 | Томский научно-исследовательский институт курортологии и физиотерапии | Method of treatment of inflammatory diseases of the female internal genital organs in subacute stage |
| SU1438770A1 (en) * | 1985-10-31 | 1988-11-23 | Белорусский научно-исследовательский институт охраны материнства и детства | Method of treatment of inflammatory diseases of the female internal genital organs |
| SU1514384A1 (en) * | 1987-05-28 | 1989-10-15 | Volg G Med I | Method of treatment of acute inflammatory diseases of internal female genital organs |
| SU1708315A1 (en) * | 1989-02-13 | 1992-01-30 | Киевский государственный институт усовершенствования врачей | Method for treating chronic diseases of female genital organs |
| SU1761144A1 (en) * | 1989-08-07 | 1992-09-15 | Томский Медицинский Институт | Method for treating acute inflammatory diseases of the female genital organs |
| SU1747084A1 (en) * | 1989-10-02 | 1992-07-15 | Кубанский медицинский институт им.Красной Армии | Method for treating the diseases of female genital organs |
| MD1119G2 (en) * | 1998-06-22 | 1999-07-31 | Георге КУШНИР | Method for female genitals inflammatory diseases treatment |
| RU2211019C1 (en) * | 2002-07-17 | 2003-08-27 | Томский научно-исследовательский институт курортологии и физиотерапии | Method for treating chronic adnexitis |
| MD3646G2 (en) * | 2007-06-08 | 2009-02-28 | Общественное Медико-Санитарное Учреждение Научно-Исследовательский Институт В Области Охраны Матери И Ребенка | Method of treating chronic inflammatory diseases of female genital organs |
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| Publication number | Publication date |
|---|---|
| MD1138Y (en) | 2017-04-30 |
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