MC2280A1 - GALACTOMANNAN DERIVATIVES FOR USE IN THE COATING OR COATING OF ACTIVE SUBSTANCES OF DRUGS - Google Patents

GALACTOMANNAN DERIVATIVES FOR USE IN THE COATING OR COATING OF ACTIVE SUBSTANCES OF DRUGS

Info

Publication number
MC2280A1
MC2280A1 MC912214A MC2214A MC2280A1 MC 2280 A1 MC2280 A1 MC 2280A1 MC 912214 A MC912214 A MC 912214A MC 2214 A MC2214 A MC 2214A MC 2280 A1 MC2280 A1 MC 2280A1
Authority
MC
Monaco
Prior art keywords
coating
active substances
drugs
mannose
galactomannans
Prior art date
Application number
MC912214A
Other languages
French (fr)
Inventor
Kurt Heinz Bauer Mm
Wohlschlegel Christian
Sarlikiotis Antonis
Original Assignee
Asta Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Pharma Ag filed Critical Asta Pharma Ag
Publication of MC2280A1 publication Critical patent/MC2280A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
    • C08B37/0093—Locust bean gum, i.e. carob bean gum, with (beta-1,4)-D-mannose units in the main chain branched with D-galactose units in (alpha-1,6), e.g. from the seeds of carob tree or Ceratonia siliqua; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Emergency Medicine (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Displays For Variable Information Using Movable Means (AREA)
  • Two-Way Televisions, Distribution Of Moving Picture Or The Like (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Galactomannans whose hydroxyl groups are completely or partially in the form of low molecular weight aliphatic, araliphatic and/or aromatic ether or ester groups, and 20 to 80% of the mannose units present in the galactomannan chain form continuous mannose blocks of 2 to 20 mannose units which are not substituted by galactose groups, for encasings and/or embeddings of solid and/or liquid active substances, which release these active substances only in the colon or in the presence of glycolytic enzymes, process for the preparation thereof and pharmaceutical compositions prepared using such galactomannans are described.
MC912214A 1990-10-18 1991-09-24 GALACTOMANNAN DERIVATIVES FOR USE IN THE COATING OR COATING OF ACTIVE SUBSTANCES OF DRUGS MC2280A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4033041 1990-10-18

Publications (1)

Publication Number Publication Date
MC2280A1 true MC2280A1 (en) 1993-06-23

Family

ID=6416524

Family Applications (1)

Application Number Title Priority Date Filing Date
MC912214A MC2280A1 (en) 1990-10-18 1991-09-24 GALACTOMANNAN DERIVATIVES FOR USE IN THE COATING OR COATING OF ACTIVE SUBSTANCES OF DRUGS

Country Status (18)

Country Link
EP (1) EP0481240B1 (en)
JP (1) JP3020684B2 (en)
KR (1) KR920008060A (en)
AT (1) ATE146191T1 (en)
AU (1) AU636800B2 (en)
BR (1) BR9104502A (en)
CA (1) CA2053569A1 (en)
CS (1) CS315091A3 (en)
DE (2) DE4131292A1 (en)
ES (1) ES2095894T3 (en)
FI (1) FI914909A (en)
HU (1) HUT58263A (en)
IE (1) IE913649A1 (en)
IL (1) IL99760A0 (en)
MC (1) MC2280A1 (en)
NO (1) NO914077L (en)
PT (1) PT99254A (en)
ZA (1) ZA918292B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4119306C2 (en) * 1991-06-12 1996-05-30 Wheli Inter Ag Organic raw materials, intermediate and end products for nutrition and for use for technical purposes that contain vital substances
FR2688422A1 (en) * 1992-03-11 1993-09-17 Coletica MICROCAPSULES WITH POLYSACCHARIDE WALLS CONTAINING PRIMARY ALCOHOL FUNCTIONS, AND COMPOSITIONS CONTAINING SAME.
DE4236025A1 (en) 1992-10-24 1994-04-28 Merck Patent Gmbh Oral dosage forms
US5459257A (en) * 1993-01-11 1995-10-17 Dainippon Ink And Chemicals, Inc. Sulfated oligoglycoside acylate and antiviral agent containing the same as active ingredient
IT1265092B1 (en) * 1993-05-31 1996-10-30 Giuliani Spa PREPARATION FOR USE AS A FOOD OR DIETARY SUPPLEMENT WITH TARGETED RELEASE IN THE COLON
US5872246A (en) * 1994-10-17 1999-02-16 Aqualon Company Ethyl guar
US5656294A (en) * 1995-06-07 1997-08-12 Cibus Pharmaceutical, Inc. Colonic delivery of drugs
US5811388A (en) * 1995-06-07 1998-09-22 Cibus Pharmaceutical, Inc. Delivery of drugs to the lower GI tract
FR2746011B1 (en) * 1996-03-12 1998-04-24 STABLE JELLY COMPOSITION CONTAINING LIPOPHILIC INGREDIENTS SENSITIVE TO OXYGEN AND/OR WATER AND ITS USE IN THE COSMETIC AND/OR DERMATOLOGICAL FIELDS
FR2768357B1 (en) 1997-09-18 1999-11-05 Snecma METHOD OF ASSEMBLING OR RECHARGING BY BRAZING-DIFFUSING PARTS IN TITANIUM ALUMINIURE
DE102011082716A1 (en) * 2011-09-14 2013-03-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Indicators element used in cell culture vessel for determining pH value of substance comprises polymeric material and indicator dye

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB498149A (en) * 1937-07-29 1939-01-04 Ig Farbenindustrie Ag Improvements in the conversion of constituents of carob beans
DE1617626C3 (en) * 1966-08-30 1975-02-13 Merck Patent Gmbh, 6100 Darmstadt Use of galactomannans to stabilize solid, water-soluble vitamin B deep 12 preparations
DE2130545A1 (en) * 1971-06-19 1972-12-21 Merck Patent Gmbh Pharmaceutical molded body

Also Published As

Publication number Publication date
DE4131292A1 (en) 1992-04-23
HUT58263A (en) 1992-02-28
AU636800B2 (en) 1993-05-06
CA2053569A1 (en) 1992-04-19
BR9104502A (en) 1992-06-09
HU913245D0 (en) 1992-01-28
KR920008060A (en) 1992-05-27
ES2095894T3 (en) 1997-03-01
IL99760A0 (en) 1992-08-18
FI914909A (en) 1992-04-19
NO914077D0 (en) 1991-10-17
ATE146191T1 (en) 1996-12-15
DE59108407D1 (en) 1997-01-23
JP3020684B2 (en) 2000-03-15
NO914077L (en) 1992-04-21
JPH04264102A (en) 1992-09-18
CS315091A3 (en) 1992-05-13
IE913649A1 (en) 1992-04-22
FI914909A0 (en) 1991-10-17
AU8595791A (en) 1992-05-21
EP0481240A2 (en) 1992-04-22
EP0481240A3 (en) 1993-04-21
PT99254A (en) 1992-08-31
ZA918292B (en) 1992-07-29
EP0481240B1 (en) 1996-12-11

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