MA65131B1 - Utilisation d'un inhibiteur d'ezh2 dans la préparation d'un médicament pour le traitement d'un lymphome à cellules t - Google Patents
Utilisation d'un inhibiteur d'ezh2 dans la préparation d'un médicament pour le traitement d'un lymphome à cellules tInfo
- Publication number
- MA65131B1 MA65131B1 MA65131A MA65131A MA65131B1 MA 65131 B1 MA65131 B1 MA 65131B1 MA 65131 A MA65131 A MA 65131A MA 65131 A MA65131 A MA 65131A MA 65131 B1 MA65131 B1 MA 65131B1
- Authority
- MA
- Morocco
- Prior art keywords
- preparation
- treatment
- cell lymphoma
- drug
- ezh2 inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne l'utilisation d'un inhibiteur d'EZH2 dans la préparation d'un médicament pour le traitement d'un lymphome à cellules T. Plus précisément, la présente invention concerne l'utilisation d'un composé tel que représenté par la formule (I) ou un sel pharmaceutiquement acceptable de celui-ci dans la préparation d'un médicament pour le traitement d'un lymphome à cellules T.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111001663 | 2021-08-30 | ||
| PCT/CN2022/115763 WO2023030299A1 (fr) | 2021-08-30 | 2022-08-30 | Utilisation d'un inhibiteur d'ezh2 dans la préparation d'un médicament pour le traitement d'un lymphome à cellules t |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA65131A1 MA65131A1 (fr) | 2024-11-29 |
| MA65131B1 true MA65131B1 (fr) | 2025-05-30 |
Family
ID=85411942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA65131A MA65131B1 (fr) | 2021-08-30 | 2022-08-30 | Utilisation d'un inhibiteur d'ezh2 dans la préparation d'un médicament pour le traitement d'un lymphome à cellules t |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20240325371A1 (fr) |
| EP (1) | EP4393490A4 (fr) |
| JP (1) | JP2024530310A (fr) |
| KR (1) | KR20240056564A (fr) |
| CN (1) | CN117956995A (fr) |
| AU (1) | AU2022340500A1 (fr) |
| CA (1) | CA3230149A1 (fr) |
| CL (1) | CL2024000593A1 (fr) |
| CO (1) | CO2024003923A2 (fr) |
| CR (1) | CR20240147A (fr) |
| IL (1) | IL311097A (fr) |
| MA (1) | MA65131B1 (fr) |
| MX (1) | MX2024002538A (fr) |
| PE (1) | PE20240881A1 (fr) |
| TW (1) | TW202327597A (fr) |
| WO (1) | WO2023030299A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ras相關疾病或病症之組合療法 |
| WO2025034702A1 (fr) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 destiné à être utilisé dans le traitement d'une maladie ou d'un trouble lié à une protéine ras |
| WO2025080946A2 (fr) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Inhibiteurs de ras |
| WO2025171296A1 (fr) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Inhibiteurs de ras |
| WO2025240847A1 (fr) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Inhibiteurs de ras |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014062732A1 (fr) * | 2012-10-15 | 2014-04-24 | Epizyme, Inc. | Composés de benzène substitué |
| WO2017084494A1 (fr) * | 2015-11-19 | 2017-05-26 | 江苏恒瑞医药股份有限公司 | Dérivé du benzofurane, son procédé de préparation et son utilisation en médecine |
| WO2018133795A1 (fr) * | 2017-01-17 | 2018-07-26 | 中国科学院合肥物质科学研究院 | Inhibiteur de l'ezh2 et son utilisation |
| WO2020192652A1 (fr) * | 2019-03-25 | 2020-10-01 | 上海华汇拓医药科技有限公司 | Procédé de préparation de composés amides et son utilisation dans le domaine médical |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014511389A (ja) * | 2011-02-28 | 2014-05-15 | エピザイム インコーポレイテッド | 置換6,5−縮合二環式ヘテロアリール化合物 |
| AU2018269268B2 (en) * | 2017-05-18 | 2022-01-06 | Jiangsu Hengrui Medicine Co., Ltd. | Crystal of benzofuran derivative free base and preparation method |
| CN110179796B (zh) * | 2018-02-23 | 2023-01-24 | 江苏恒瑞医药股份有限公司 | 一种苯并呋喃类衍生物的组合物及制备方法 |
| CN113767096B (zh) * | 2019-05-10 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | 一种6-取代氨基苯并呋喃化合物的制备方法 |
| TW202126302A (zh) * | 2019-09-30 | 2021-07-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ezh2抑制劑與免疫檢查點抑制劑、酪胺酸激酶抑制劑聯合在製備治療腫瘤藥物中的用途 |
| WO2021063331A1 (fr) * | 2019-09-30 | 2021-04-08 | 江苏恒瑞医药股份有限公司 | UTILISATION D'UNE COMBINAISON D'UN INHIBITEUR D'EZH2 ET D'UNE PROTÉINE DE FUSION CONTENANT UN RÉCEPTEUR DE TGF-β DANS LA PRÉPARATION DE MÉDICAMENTS POUR LE TRAITEMENT DE TUMEURS |
-
2022
- 2022-08-30 JP JP2024513260A patent/JP2024530310A/ja active Pending
- 2022-08-30 MX MX2024002538A patent/MX2024002538A/es unknown
- 2022-08-30 PE PE2024000331A patent/PE20240881A1/es unknown
- 2022-08-30 US US18/687,272 patent/US20240325371A1/en active Pending
- 2022-08-30 MA MA65131A patent/MA65131B1/fr unknown
- 2022-08-30 KR KR1020247010785A patent/KR20240056564A/ko active Pending
- 2022-08-30 AU AU2022340500A patent/AU2022340500A1/en active Pending
- 2022-08-30 TW TW111132788A patent/TW202327597A/zh unknown
- 2022-08-30 CN CN202280058583.6A patent/CN117956995A/zh active Pending
- 2022-08-30 CR CR20240147A patent/CR20240147A/es unknown
- 2022-08-30 CA CA3230149A patent/CA3230149A1/fr active Pending
- 2022-08-30 EP EP22863434.1A patent/EP4393490A4/fr active Pending
- 2022-08-30 WO PCT/CN2022/115763 patent/WO2023030299A1/fr not_active Ceased
- 2022-08-30 IL IL311097A patent/IL311097A/en unknown
-
2024
- 2024-02-27 CL CL2024000593A patent/CL2024000593A1/es unknown
- 2024-03-27 CO CONC2024/0003923A patent/CO2024003923A2/es unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014062732A1 (fr) * | 2012-10-15 | 2014-04-24 | Epizyme, Inc. | Composés de benzène substitué |
| WO2017084494A1 (fr) * | 2015-11-19 | 2017-05-26 | 江苏恒瑞医药股份有限公司 | Dérivé du benzofurane, son procédé de préparation et son utilisation en médecine |
| WO2018133795A1 (fr) * | 2017-01-17 | 2018-07-26 | 中国科学院合肥物质科学研究院 | Inhibiteur de l'ezh2 et son utilisation |
| WO2020192652A1 (fr) * | 2019-03-25 | 2020-10-01 | 上海华汇拓医药科技有限公司 | Procédé de préparation de composés amides et son utilisation dans le domaine médical |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022340500A1 (en) | 2024-04-11 |
| EP4393490A1 (fr) | 2024-07-03 |
| CA3230149A1 (fr) | 2023-03-09 |
| MA65131A1 (fr) | 2024-11-29 |
| MX2024002538A (es) | 2024-03-19 |
| JP2024530310A (ja) | 2024-08-16 |
| US20240325371A1 (en) | 2024-10-03 |
| CN117956995A (zh) | 2024-04-30 |
| EP4393490A4 (fr) | 2025-08-27 |
| CO2024003923A2 (es) | 2024-06-27 |
| IL311097A (en) | 2024-04-01 |
| KR20240056564A (ko) | 2024-04-30 |
| PE20240881A1 (es) | 2024-04-24 |
| CL2024000593A1 (es) | 2024-07-05 |
| CR20240147A (es) | 2024-09-20 |
| TW202327597A (zh) | 2023-07-16 |
| WO2023030299A1 (fr) | 2023-03-09 |
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