MA60100B1 - Dérivés de tétrazole utiles en tant qu'inhibiteurs de trpa1 - Google Patents
Dérivés de tétrazole utiles en tant qu'inhibiteurs de trpa1Info
- Publication number
- MA60100B1 MA60100B1 MA60100A MA60100A MA60100B1 MA 60100 B1 MA60100 B1 MA 60100B1 MA 60100 A MA60100 A MA 60100A MA 60100 A MA60100 A MA 60100A MA 60100 B1 MA60100 B1 MA 60100B1
- Authority
- MA
- Morocco
- Prior art keywords
- tetrazole derivatives
- derivatives useful
- trpa1
- trpa1 inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne certains dérivés de tétrazole qui sont des inhibiteurs de l'ankyrine à potentiel de récepteur transitoire 1 (TRPA1) et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par inhibition de TRPA1. L'invention concerne également des compositions pharmaceutiques les contenant et des procédés de préparation desdits composés.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20182988 | 2020-06-29 | ||
| PCT/EP2021/067470 WO2022002782A1 (fr) | 2020-06-29 | 2021-06-25 | Dérivés de tétrazole utiles en tant qu'inhibiteurs de trpa1 |
| EP21735303.6A EP4171563B1 (fr) | 2020-06-29 | 2021-06-25 | Dérivés de tétrazole utiles en tant qu'inhibiteurs de trpa1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA60100B1 true MA60100B1 (fr) | 2025-11-28 |
Family
ID=71401656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA60100A MA60100B1 (fr) | 2020-06-29 | 2021-06-25 | Dérivés de tétrazole utiles en tant qu'inhibiteurs de trpa1 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US11884652B2 (fr) |
| EP (1) | EP4171563B1 (fr) |
| JP (1) | JP7539501B2 (fr) |
| KR (1) | KR20230028547A (fr) |
| CN (3) | CN121159510A (fr) |
| AR (1) | AR122779A1 (fr) |
| AU (1) | AU2021298800A1 (fr) |
| BR (1) | BR112022021865A2 (fr) |
| CA (1) | CA3181350A1 (fr) |
| CL (1) | CL2022003329A1 (fr) |
| CO (1) | CO2022016755A2 (fr) |
| CR (1) | CR20220667A (fr) |
| DK (1) | DK4171563T3 (fr) |
| DO (1) | DOP2022000262A (fr) |
| EC (1) | ECSP22088664A (fr) |
| ES (1) | ES3049803T3 (fr) |
| FI (1) | FI4171563T3 (fr) |
| HR (1) | HRP20251260T1 (fr) |
| HU (1) | HUE073295T2 (fr) |
| IL (1) | IL299175A (fr) |
| LT (1) | LT4171563T (fr) |
| MA (1) | MA60100B1 (fr) |
| MX (1) | MX2022016357A (fr) |
| PE (1) | PE20231852A1 (fr) |
| PL (1) | PL4171563T3 (fr) |
| PT (1) | PT4171563T (fr) |
| RS (1) | RS67325B1 (fr) |
| SA (1) | SA522441965B1 (fr) |
| WO (1) | WO2022002782A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7617306B2 (ja) | 2021-04-14 | 2025-01-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｔｒｐａ１阻害剤としてのウラシル誘導体 |
| US20250136587A1 (en) * | 2022-02-03 | 2025-05-01 | D. E. Shaw Research, Llc | N3-substituted uracil compounds as trpa1 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7361654B2 (en) | 2005-01-13 | 2008-04-22 | Bristol-Myers Squibb Co. | Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| JP2011231015A (ja) * | 2008-08-29 | 2011-11-17 | Taiho Yakuhin Kogyo Kk | 含窒素複素環を有する新規ウラシル化合物又はその塩 |
| WO2017060488A1 (fr) | 2015-10-09 | 2017-04-13 | Almirall, S.A. | Nouveaux antagonistes de trpa1 |
| WO2018096159A1 (fr) * | 2016-11-28 | 2018-05-31 | F. Hoffmann-La Roche Ag | Oxadiazolones en tant qu'inhibiteurs de canal potentiel récepteur transitoire |
| JP7617306B2 (ja) | 2021-04-14 | 2025-01-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｔｒｐａ１阻害剤としてのウラシル誘導体 |
-
2021
- 2021-06-24 US US17/356,748 patent/US11884652B2/en active Active
- 2021-06-25 KR KR1020237003324A patent/KR20230028547A/ko active Pending
- 2021-06-25 WO PCT/EP2021/067470 patent/WO2022002782A1/fr not_active Ceased
- 2021-06-25 HU HUE21735303A patent/HUE073295T2/hu unknown
- 2021-06-25 CA CA3181350A patent/CA3181350A1/fr active Pending
- 2021-06-25 PE PE2022003065A patent/PE20231852A1/es unknown
- 2021-06-25 CN CN202511215812.2A patent/CN121159510A/zh active Pending
- 2021-06-25 MA MA60100A patent/MA60100B1/fr unknown
- 2021-06-25 PL PL21735303.6T patent/PL4171563T3/pl unknown
- 2021-06-25 JP JP2022578729A patent/JP7539501B2/ja active Active
- 2021-06-25 CN CN202511215814.1A patent/CN121085901A/zh active Pending
- 2021-06-25 PT PT217353036T patent/PT4171563T/pt unknown
- 2021-06-25 CR CR20220667A patent/CR20220667A/es unknown
- 2021-06-25 CN CN202180045969.9A patent/CN115803029B/zh active Active
- 2021-06-25 MX MX2022016357A patent/MX2022016357A/es unknown
- 2021-06-25 EP EP21735303.6A patent/EP4171563B1/fr active Active
- 2021-06-25 BR BR112022021865A patent/BR112022021865A2/pt unknown
- 2021-06-25 DK DK21735303.6T patent/DK4171563T3/da active
- 2021-06-25 IL IL299175A patent/IL299175A/en unknown
- 2021-06-25 AU AU2021298800A patent/AU2021298800A1/en active Pending
- 2021-06-25 LT LTEPPCT/EP2021/067470T patent/LT4171563T/lt unknown
- 2021-06-25 ES ES21735303T patent/ES3049803T3/es active Active
- 2021-06-25 HR HRP20251260TT patent/HRP20251260T1/hr unknown
- 2021-06-25 RS RS20251037A patent/RS67325B1/sr unknown
- 2021-06-25 FI FIEP21735303.6T patent/FI4171563T3/fi active
- 2021-06-28 AR ARP210101795A patent/AR122779A1/es unknown
-
2022
- 2022-11-21 EC ECSENADI202288664A patent/ECSP22088664A/es unknown
- 2022-11-22 DO DO2022000262A patent/DOP2022000262A/es unknown
- 2022-11-22 CO CONC2022/0016755A patent/CO2022016755A2/es unknown
- 2022-11-25 CL CL2022003329A patent/CL2022003329A1/es unknown
- 2022-12-29 SA SA522441965A patent/SA522441965B1/ar unknown
-
2023
- 2023-12-05 US US18/529,485 patent/US20250092019A1/en not_active Abandoned
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