MA53783A1 - Rifamycin analogs and antibody-drug conjugates thereof - Google Patents

Rifamycin analogs and antibody-drug conjugates thereof

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Publication number
MA53783A1
MA53783A1 MA53783A MA53783A MA53783A1 MA 53783 A1 MA53783 A1 MA 53783A1 MA 53783 A MA53783 A MA 53783A MA 53783 A MA53783 A MA 53783A MA 53783 A1 MA53783 A1 MA 53783A1
Authority
MA
Morocco
Prior art keywords
antibody
drug conjugates
growth
infections
aureus
Prior art date
Application number
MA53783A
Other languages
French (fr)
Inventor
Thomas Nittoli
Seungyong Sean Choi
Mrinmoy Saha
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Priority claimed from PCT/US2019/067914 external-priority patent/WO2020132483A1/en
Publication of MA53783A1 publication Critical patent/MA53783A1/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés analogues de rifamycine, des intermédiaires et des précurseurs de ceux-ci, et des compositions pharmaceutiques capables d'inhiber la croissance bactérienne (par exemple, la croissance de s. Aureus) et de traiter des infections bactériennes (par exemple, des infections par s. Aureus). L'invention concerne en outre des conjugués anticorps-médicament de composés analogues de rifamycine et d'anticorps, par exemple, des anticorps spécifiques contre des cibles associées à une maladie infectieuse comme le récepteur de glycoprotéine membranaire (msr1), des acides téichoïques de paroi (wta) ou une protéine a, et des procédés d'utilisation de ceux-ci pour inhiber la croissance bactérienne et traiter des infections bactériennes.Disclosed herein are rifamycin analog compounds, intermediates and precursors thereof, and pharmaceutical compositions capable of inhibiting bacterial growth (eg, growth of S. Aureus) and treating bacterial infections (eg. example, S. Aureus infections). The invention further relates to antibody-drug conjugates of rifamycin analog compounds and antibodies, for example, antibodies specific against targets associated with infectious disease such as the membrane glycoprotein receptor (msr1), cell wall teichoic acids (wta) or a protein, and methods of using the same to inhibit bacterial growth and treat bacterial infections.

MA53783A 2018-12-21 2019-12-20 Rifamycin analogs and antibody-drug conjugates thereof MA53783A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862783506P 2018-12-21 2018-12-21
PCT/US2019/067914 WO2020132483A1 (en) 2018-12-21 2019-12-20 Rifamycin analogs and antibody-drug conjugates thereof

Publications (1)

Publication Number Publication Date
MA53783A1 true MA53783A1 (en) 2022-09-30

Family

ID=83598749

Family Applications (2)

Application Number Title Priority Date Filing Date
MA53783A MA53783A1 (en) 2018-12-21 2019-12-20 Rifamycin analogs and antibody-drug conjugates thereof
MA59341A MA59341A1 (en) 2018-12-21 2021-07-28 Rifamycin analogs and antibody-drug conjugates thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA59341A MA59341A1 (en) 2018-12-21 2021-07-28 Rifamycin analogs and antibody-drug conjugates thereof

Country Status (1)

Country Link
MA (2) MA53783A1 (en)

Also Published As

Publication number Publication date
MA59341A1 (en) 2023-05-31

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