EA202191739A1 - ANALOGUES OF RIFAMYCIN AND ANTIBODY-DRUG CONJUGATES WITH THEM - Google Patents
ANALOGUES OF RIFAMYCIN AND ANTIBODY-DRUG CONJUGATES WITH THEMInfo
- Publication number
- EA202191739A1 EA202191739A1 EA202191739A EA202191739A EA202191739A1 EA 202191739 A1 EA202191739 A1 EA 202191739A1 EA 202191739 A EA202191739 A EA 202191739A EA 202191739 A EA202191739 A EA 202191739A EA 202191739 A1 EA202191739 A1 EA 202191739A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- rifamycin
- antibody
- drug conjugates
- analogues
- growth
- Prior art date
Links
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к соединениям-аналогам рифамицина, их промежуточным соединениям и прекурсорам, фармацевтическим композициям, способным к ингибированию роста бактерий (например, роста S. aureus), и лечению бактериальных инфекций (например, инфекций S. aureus). Изобретение дополнительно относится к конъюгатам антитело-лекарственное средство с соединениями-аналогами рифамицина и антителами, например с антителами, специфичными в отношении связанных с инфекционными заболеваниями мишеней, таких как рецептор мембранного гликопротеина (MSR1), тейхоевые кислоты стенки (WTA) или белок A, и способам их применения для ингибирования бактериального роста и лечения бактериальных инфекций.The invention relates to analog compounds of rifamycin, their intermediates and precursors, pharmaceutical compositions capable of inhibiting bacterial growth (for example, the growth of S. aureus), and the treatment of bacterial infections (for example, S. aureus infections). The invention further relates to antibody-drug conjugates with rifamycin analog compounds and antibodies, for example antibodies specific for targets associated with infectious diseases, such as membrane glycoprotein receptor (MSR1), wall teichoic acid (WTA) or protein A, and methods of their use for inhibiting bacterial growth and treating bacterial infections.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962844860P | 2019-05-08 | 2019-05-08 | |
PCT/US2019/067914 WO2020132483A1 (en) | 2018-12-21 | 2019-12-20 | Rifamycin analogs and antibody-drug conjugates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202191739A1 true EA202191739A1 (en) | 2021-10-13 |
Family
ID=78572583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202191739A EA202191739A1 (en) | 2019-05-08 | 2019-12-20 | ANALOGUES OF RIFAMYCIN AND ANTIBODY-DRUG CONJUGATES WITH THEM |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA202191739A1 (en) |
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2019
- 2019-12-20 EA EA202191739A patent/EA202191739A1/en unknown
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