MA50737B1 - Human Antibodies Against Middle East Respiratory Syndrome Coronavirus Monoclonal Spike Protein - Google Patents

Human Antibodies Against Middle East Respiratory Syndrome Coronavirus Monoclonal Spike Protein

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Publication number
MA50737B1
MA50737B1 MA50737A MA50737A MA50737B1 MA 50737 B1 MA50737 B1 MA 50737B1 MA 50737 A MA50737 A MA 50737A MA 50737 A MA50737 A MA 50737A MA 50737 B1 MA50737 B1 MA 50737B1
Authority
MA
Morocco
Prior art keywords
mers
spike protein
antibodies
cov
bind
Prior art date
Application number
MA50737A
Other languages
French (fr)
Other versions
MA50737A1 (en
Inventor
Christos Kyratsous
Neil Stahl
Sumathi Sivapalasingam
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2015/031800 external-priority patent/WO2015179535A1/en
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MA50737A1 publication Critical patent/MA50737A1/en
Publication of MA50737B1 publication Critical patent/MA50737B1/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne des anticorps monoclonaux qui se lient à la protéine de pic monoclonal du coronavirus du syndrome respiratoire du moyen-orient (mers-cov), ainsi que les méthodes d'utilisation de ceux-ci. Dans plusieurs modes de réalisation de l'invention, les anticorps sont des anticorps complètement humains qui se lient à la protéine de pic monoclonal du mers-cov. Dans certains modes de réalisation, les anticorps de l'invention peuvent servir à inhiber ou neutraliser l'activité du mers-cov, offrant ainsi un moyen de traitement ou de prévention d'une infection à mers chez l'homme. Dans certains modes de réalisation, l'invention fournit une association d'un ou de plusieurs anticorps qui se lient à la protéine de pic monoclonal du mers-cov, utilisables dans le traitement d'une infection à mers. Dans certains modes de réalisation, les anticorps unique ou multiples se lient à des épitopes distincts et non-concurrents appartenant au domaine de liaison du récepteur de la protéine de pic monoclonal du mers-cov.The present invention relates to monoclonal antibodies that bind to the monoclonal spike protein of middle east respiratory syndrome coronavirus (mers-cov), as well as methods of using the same. In several embodiments of the invention, the antibodies are fully human antibodies that bind to the mers-cov monoclonal spike protein. In certain embodiments, the antibodies of the invention may serve to inhibit or neutralize mers-cov activity, thereby providing a means of treating or preventing mers infection in humans. In certain embodiments, the invention provides a combination of one or more antibodies that bind to the mers-cov monoclonal spike protein, useful in the treatment of a mers infection. In some embodiments, the single or multiple antibodies bind to distinct and non-competing epitopes belonging to the monoclonal spike protein receptor binding domain of mers-cov.

MA50737A 2014-05-23 2016-10-20 Human Antibodies Against Middle East Respiratory Syndrome Coronavirus Monoclonal Spike Protein MA50737B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462002233P 2014-05-23 2014-05-23
PCT/US2015/031800 WO2015179535A1 (en) 2014-05-23 2015-05-20 Human antibodies to middle east respiratory syndrome -coronavirus spike protein

Publications (2)

Publication Number Publication Date
MA50737A1 MA50737A1 (en) 2021-12-31
MA50737B1 true MA50737B1 (en) 2023-03-31

Family

ID=62203545

Family Applications (3)

Application Number Title Priority Date Filing Date
MA56083A MA56083B1 (en) 2014-05-23 2015-05-20 HUMAN ANTIBODIES AGAINST MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS MONOCLONAL PIC PROTEIN
MA39397A MA39397A1 (en) 2014-05-23 2015-05-20 Human antibodies against monoclonal peak protein of mid-east respiratory syndrome coronavirus
MA50737A MA50737B1 (en) 2014-05-23 2016-10-20 Human Antibodies Against Middle East Respiratory Syndrome Coronavirus Monoclonal Spike Protein

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MA56083A MA56083B1 (en) 2014-05-23 2015-05-20 HUMAN ANTIBODIES AGAINST MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS MONOCLONAL PIC PROTEIN
MA39397A MA39397A1 (en) 2014-05-23 2015-05-20 Human antibodies against monoclonal peak protein of mid-east respiratory syndrome coronavirus

Country Status (1)

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MA (3) MA56083B1 (en)

Also Published As

Publication number Publication date
MA39397A1 (en) 2018-03-30
MA56083A1 (en) 2023-04-28
MA50737A1 (en) 2021-12-31
MA56083B1 (en) 2023-09-27

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