MA50737A1 - Human Antibodies Against Middle East Respiratory Syndrome Coronavirus Monoclonal Spike Protein - Google Patents
Human Antibodies Against Middle East Respiratory Syndrome Coronavirus Monoclonal Spike ProteinInfo
- Publication number
- MA50737A1 MA50737A1 MA50737A MA50737A MA50737A1 MA 50737 A1 MA50737 A1 MA 50737A1 MA 50737 A MA50737 A MA 50737A MA 50737 A MA50737 A MA 50737A MA 50737 A1 MA50737 A1 MA 50737A1
- Authority
- MA
- Morocco
- Prior art keywords
- mers
- spike protein
- antibodies
- cov
- bind
- Prior art date
Links
- 229940096437 Protein S Drugs 0.000 title abstract 5
- 101710198474 Spike protein Proteins 0.000 title abstract 5
- 241000127282 Middle East respiratory syndrome-related coronavirus Species 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne des anticorps monoclonaux qui se lient à la protéine de pic monoclonal du coronavirus du syndrome respiratoire du moyen-orient (mers-cov), ainsi que les méthodes d'utilisation de ceux-ci. Dans plusieurs modes de réalisation de l'invention, les anticorps sont des anticorps complètement humains qui se lient à la protéine de pic monoclonal du mers-cov. Dans certains modes de réalisation, les anticorps de l'invention peuvent servir à inhiber ou neutraliser l'activité du mers-cov, offrant ainsi un moyen de traitement ou de prévention d'une infection à mers chez l'homme. Dans certains modes de réalisation, l'invention fournit une association d'un ou de plusieurs anticorps qui se lient à la protéine de pic monoclonal du mers-cov, utilisables dans le traitement d'une infection à mers. Dans certains modes de réalisation, les anticorps unique ou multiples se lient à des épitopes distincts et non-concurrents appartenant au domaine de liaison du récepteur de la protéine de pic monoclonal du mers-cov.The present invention relates to monoclonal antibodies that bind to the monoclonal spike protein of middle east respiratory syndrome coronavirus (mers-cov), as well as methods of using the same. In several embodiments of the invention, the antibodies are fully human antibodies that bind to the mers-cov monoclonal spike protein. In certain embodiments, the antibodies of the invention may serve to inhibit or neutralize mers-cov activity, thereby providing a means of treating or preventing mers infection in humans. In certain embodiments, the invention provides a combination of one or more antibodies that bind to the mers-cov monoclonal spike protein, useful in the treatment of a mers infection. In some embodiments, the single or multiple antibodies bind to distinct and non-competing epitopes belonging to the monoclonal spike protein receptor binding domain of mers-cov.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462002233P | 2014-05-23 | 2014-05-23 | |
| PCT/US2015/031800 WO2015179535A1 (en) | 2014-05-23 | 2015-05-20 | Human antibodies to middle east respiratory syndrome -coronavirus spike protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA50737A1 true MA50737A1 (en) | 2021-12-31 |
| MA50737B1 MA50737B1 (en) | 2023-03-31 |
Family
ID=62203545
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA56083A MA56083B1 (en) | 2014-05-23 | 2015-05-20 | HUMAN ANTIBODIES AGAINST MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS MONOCLONAL PIC PROTEIN |
| MA39397A MA39397A1 (en) | 2014-05-23 | 2015-05-20 | Human antibodies against monoclonal peak protein of mid-east respiratory syndrome coronavirus |
| MA50737A MA50737B1 (en) | 2014-05-23 | 2016-10-20 | Human Antibodies Against Middle East Respiratory Syndrome Coronavirus Monoclonal Spike Protein |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA56083A MA56083B1 (en) | 2014-05-23 | 2015-05-20 | HUMAN ANTIBODIES AGAINST MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS MONOCLONAL PIC PROTEIN |
| MA39397A MA39397A1 (en) | 2014-05-23 | 2015-05-20 | Human antibodies against monoclonal peak protein of mid-east respiratory syndrome coronavirus |
Country Status (1)
| Country | Link |
|---|---|
| MA (3) | MA56083B1 (en) |
-
2015
- 2015-05-20 MA MA56083A patent/MA56083B1/en unknown
- 2015-05-20 MA MA39397A patent/MA39397A1/en unknown
-
2016
- 2016-10-20 MA MA50737A patent/MA50737B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA50737B1 (en) | 2023-03-31 |
| MA56083B1 (en) | 2023-09-27 |
| MA56083A1 (en) | 2023-04-28 |
| MA39397A1 (en) | 2018-03-30 |
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