MA39397A1 - Human antibodies against monoclonal peak protein of mid-east respiratory syndrome coronavirus - Google Patents

Human antibodies against monoclonal peak protein of mid-east respiratory syndrome coronavirus

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Publication number
MA39397A1
MA39397A1 MA39397A MA39397A MA39397A1 MA 39397 A1 MA39397 A1 MA 39397A1 MA 39397 A MA39397 A MA 39397A MA 39397 A MA39397 A MA 39397A MA 39397 A1 MA39397 A1 MA 39397A1
Authority
MA
Morocco
Prior art keywords
antibodies
mers
peak protein
cov
bind
Prior art date
Application number
MA39397A
Other languages
French (fr)
Inventor
Sumathi Sivapalasingam
Christos Kyratsous
Neil Stahl
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Priority claimed from PCT/US2015/031800 external-priority patent/WO2015179535A1/en
Publication of MA39397A1 publication Critical patent/MA39397A1/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne des anticorps monoclonaux qui se lient à la protéine de pic monoclonal du coronavirus du syndrome respiratoire du moyen-orient (mers-cov), ainsi que les méthodes d'utilisation de ceux-ci. Dans plusieurs modes de réalisation de l'invention, les anticorps sont des anticorps complètement humains qui se lient à la protéine de pic monoclonal du mers-cov. Dans certains modes de réalisation, les anticorps de l'invention peuvent servir à inhiber ou neutraliser l'activité du mers-cov, offrant ainsi un moyen de traitement ou de prévention d'une infection à mers chez l'homme. Dans certains modes de réalisation, l'invention fournit une association d'un ou de plusieurs anticorps qui se lient à la protéine de pic monoclonal du mers-cov, utilisables dans le traitement d'une infection à mers. Dans certains modes de réalisation, les anticorps unique ou multiples se lient à des épitopes distincts et non-concurrents appartenant au domaine de liaison du récepteur de la protéine de pic monoclonal du mers-cov.The present invention relates to monoclonal antibodies that bind to the mid-east respiratory syndrome coronavirus (mers-cov) monoclonal peak protein, as well as methods of use thereof. In several embodiments of the invention, the antibodies are fully human antibodies that bind to the mers-cov monoclonal peak protein. In some embodiments, the antibodies of the invention may be used to inhibit or neutralize mers-cov activity, thereby providing a means for treating or preventing human infection in humans. In some embodiments, the invention provides a combination of one or more antibodies that bind to the mers-cov monoclonal peak protein, useful in the treatment of an infection at sea. In some embodiments, the single or multiple antibodies bind to distinct and non-competing epitopes belonging to the mers-cov monoclonal peak protein receptor binding domain.

MA39397A 2014-05-23 2015-05-20 Human antibodies against monoclonal peak protein of mid-east respiratory syndrome coronavirus MA39397A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462002233P 2014-05-23 2014-05-23
PCT/US2015/031800 WO2015179535A1 (en) 2014-05-23 2015-05-20 Human antibodies to middle east respiratory syndrome -coronavirus spike protein

Publications (1)

Publication Number Publication Date
MA39397A1 true MA39397A1 (en) 2018-03-30

Family

ID=62203545

Family Applications (3)

Application Number Title Priority Date Filing Date
MA56083A MA56083B1 (en) 2014-05-23 2015-05-20 HUMAN ANTIBODIES AGAINST MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS MONOCLONAL PIC PROTEIN
MA39397A MA39397A1 (en) 2014-05-23 2015-05-20 Human antibodies against monoclonal peak protein of mid-east respiratory syndrome coronavirus
MA50737A MA50737B1 (en) 2014-05-23 2016-10-20 Human Antibodies Against Middle East Respiratory Syndrome Coronavirus Monoclonal Spike Protein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA56083A MA56083B1 (en) 2014-05-23 2015-05-20 HUMAN ANTIBODIES AGAINST MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS MONOCLONAL PIC PROTEIN

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA50737A MA50737B1 (en) 2014-05-23 2016-10-20 Human Antibodies Against Middle East Respiratory Syndrome Coronavirus Monoclonal Spike Protein

Country Status (1)

Country Link
MA (3) MA56083B1 (en)

Also Published As

Publication number Publication date
MA50737B1 (en) 2023-03-31
MA56083A1 (en) 2023-04-28
MA50737A1 (en) 2021-12-31
MA56083B1 (en) 2023-09-27

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