MA47137B1 - Pd-1 and lag-3 binding molecules and their methods of use - Google Patents
Pd-1 and lag-3 binding molecules and their methods of useInfo
- Publication number
- MA47137B1 MA47137B1 MA47137A MA47137A MA47137B1 MA 47137 B1 MA47137 B1 MA 47137B1 MA 47137 A MA47137 A MA 47137A MA 47137 A MA47137 A MA 47137A MA 47137 B1 MA47137 B1 MA 47137B1
- Authority
- MA
- Morocco
- Prior art keywords
- mab
- binding
- antibodies
- methods
- molecules
- Prior art date
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne des anticorps anti-pd-1 sélectionnés capables de se lier à la fois au pd-1 de singe cynomolgus et au pd-1 humain : pd-1 mab 1, pd-1 mab 2, pd-1 mab 3, pd- 1 mab 4, pd-1 mab 5, pd-1 mab 6, pd-1 mab 7, pd-1 mab 8, pd-1 mab 9, pd-1 mab 10, pd-1 mab 11, pd-1 mab 12, mab pd-1 13, mab pd-1 14 ou mab pd-1 15, et aux versions humanisées et chimériques de ces anticorps. L'invention concerne en outre des molécules se liant à pd-1 qui comprennent des fragments se liant à pd-1 de tels anticorps anti-pd-1, des immunocongugates et des molécules bispécifiques, y compris des diabodies, des bite, des anticorps bispécifiques, etc., qui comprennent (i) de tels fragments se liant à pd-1, et (ii) un domaine capable de lier un épitope d'une molécule impliquée dans la régulation d'un point de contrôle immunitaire présent à la surface d'une cellule immunitaire. La présente invention concerne également des procédés d'utilisation de molécules qui se lient à pd-1 pour stimuler des réponses immunitaires, ainsi que des procédés de détection de pd-1.The present invention relates to selected anti-pd-1 antibodies capable of binding to both cynomolgus monkey pd-1 and human pd-1: pd-1 mab 1, pd-1 mab 2, pd-1 mab 3 , pd- 1 mab 4, pd-1 mab 5, pd-1 mab 6, pd-1 mab 7, pd-1 mab 8, pd-1 mab 9, pd-1 mab 10, pd-1 mab 11, pd -1 mab 12, mab pd-1 13, mab pd-1 14 or mab pd-1 15, and humanized and chimeric versions of these antibodies. The invention further relates to pd-1 binding molecules which comprise pd-1 binding fragments of such anti-pd-1 antibodies, immunocongugates and bispecific molecules, including diabodies, bite, antibodies. bispecific, etc., which include (i) such fragments binding to pd-1, and (ii) a domain capable of binding an epitope of a molecule involved in the regulation of an immune checkpoint present on the surface of an immune cell. The present invention also relates to methods of using molecules that bind to pd-1 to stimulate immune responses, as well as methods of detecting pd-1.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562198867P | 2015-07-30 | 2015-07-30 | |
| US201562239559P | 2015-10-09 | 2015-10-09 | |
| US201562255140P | 2015-11-13 | 2015-11-13 | |
| US201662322974P | 2016-04-15 | 2016-04-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA47137A MA47137A (en) | 2019-10-30 |
| MA47137B1 true MA47137B1 (en) | 2021-08-31 |
Family
ID=60244687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA47137A MA47137B1 (en) | 2015-07-30 | 2016-07-28 | Pd-1 and lag-3 binding molecules and their methods of use |
Country Status (2)
| Country | Link |
|---|---|
| AR (2) | AR105520A1 (en) |
| MA (1) | MA47137B1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210044221A (en) * | 2018-07-11 | 2021-04-22 | 카 메디컬 리미티드 | PD1-4-1BBL variant fusion protein and method of use thereof |
| CN116854820B (en) * | 2023-06-26 | 2024-02-06 | 华中科技大学同济医学院附属协和医院 | PD-1 non-blocking scavenging antibodies and uses thereof |
-
2016
- 2016-07-28 AR ARP160102301A patent/AR105520A1/en unknown
- 2016-07-28 MA MA47137A patent/MA47137B1/en unknown
-
2020
- 2020-09-29 AR ARP200102705A patent/AR120117A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR105520A1 (en) | 2017-10-11 |
| AR120117A2 (en) | 2022-02-02 |
| MA47137A (en) | 2019-10-30 |
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