MA38503A1 - Anti-il-33 antibodies and their uses - Google Patents
Anti-il-33 antibodies and their usesInfo
- Publication number
- MA38503A1 MA38503A1 MA38503A MA38503A MA38503A1 MA 38503 A1 MA38503 A1 MA 38503A1 MA 38503 A MA38503 A MA 38503A MA 38503 A MA38503 A MA 38503A MA 38503 A1 MA38503 A1 MA 38503A1
- Authority
- MA
- Morocco
- Prior art keywords
- antibodies
- attenuate
- bind
- interaction
- inhibit
- Prior art date
Links
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Cette invention concerne des anticorps qui se lient à l'interleukine-33 (il-33) et des procédés pour les utiliser. L'invention concerne des anticorps qui inhibent ou atténuent la signalisation médiée par l'il-33. Les anticorps selon l'invention peuvent servir à bloquer l'interaction il-33/st2. Rn variante, certains anticorps selon l'invention inhibent ou atténuent la signalisation médiée par l'il-33 sans bloquer l'interaction il-33/st2. Dans certains modes de réalisation, les anticorps selon l'invention sont des anticorps entièrement humains qui se lient à l'il-33 humain à une affinité élevée. Les anticorps selon l'invention sont utiles pour traiter les maladies et les troubles associés à la signalisation il-33 et/ou à l'expression cellulaire d'il-33, comme les maladies inflammatoires ou les maladies allergiques.This invention relates to antibodies that bind to interleukin-33 (IL-33) and methods for their use. The present invention provides antibodies that inhibit or attenuate il-33 mediated signaling. The antibodies according to the invention can be used to block the il-33 / st2 interaction. Alternatively, certain antibodies according to the invention inhibit or attenuate IL-33 mediated signaling without blocking the IL-33 / ST2 interaction. In some embodiments, the antibodies of the invention are all-human antibodies that bind to human at high affinity. The antibodies of the invention are useful for treating diseases and disorders associated with il-33 signaling and / or il-33 cell expression, such as inflammatory diseases or allergic diseases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361778687P | 2013-03-13 | 2013-03-13 | |
PCT/US2014/023930 WO2014164959A2 (en) | 2013-03-13 | 2014-03-12 | Anti-il-33 antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MA38503A1 true MA38503A1 (en) | 2017-07-31 |
Family
ID=56119034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38503A MA38503A1 (en) | 2013-03-13 | 2014-03-12 | Anti-il-33 antibodies and their uses |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR095235A1 (en) |
MA (1) | MA38503A1 (en) |
-
2014
- 2014-03-11 AR ARP140100844A patent/AR095235A1/en active IP Right Grant
- 2014-03-12 MA MA38503A patent/MA38503A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR095235A1 (en) | 2015-09-30 |
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