MA46892A - Composés d'alcène tétrasubstitués et leur utilisation pour le traitement du cancer du sein - Google Patents

Composés d'alcène tétrasubstitués et leur utilisation pour le traitement du cancer du sein

Info

Publication number
MA46892A
MA46892A MA046892A MA46892A MA46892A MA 46892 A MA46892 A MA 46892A MA 046892 A MA046892 A MA 046892A MA 46892 A MA46892 A MA 46892A MA 46892 A MA46892 A MA 46892A
Authority
MA
Morocco
Prior art keywords
treatment
breast cancer
alkene compounds
tetrasubstituted alkene
tetrasubstituted
Prior art date
Application number
MA046892A
Other languages
English (en)
Inventor
Mark Bock
Ming-Hong Hao
Manav Korpal
Nicholas Larsen
Lorna Helen Mitchell
Vijay Kumar Nyavanandi
Morgan O'shea
Sudeep Prajapati
Xiaoling Puyang
Dominic Reynolds
Nathalie Rioux
Susanta Samajdar
Thiwanka Samarakoon
Peter Gerard Smith
John Wang
Guo Zhu Zheng
Ping Zhu
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MA46892A publication Critical patent/MA46892A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA046892A 2016-11-24 2017-11-22 Composés d'alcène tétrasubstitués et leur utilisation pour le traitement du cancer du sein MA46892A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201641040196 2016-11-24
IN201741018583 2017-05-26

Publications (1)

Publication Number Publication Date
MA46892A true MA46892A (fr) 2021-04-14

Family

ID=60703082

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046892A MA46892A (fr) 2016-11-24 2017-11-22 Composés d'alcène tétrasubstitués et leur utilisation pour le traitement du cancer du sein

Country Status (7)

Country Link
US (2) US20180141913A1 (fr)
EP (1) EP3544974A1 (fr)
JP (1) JP2019535778A (fr)
CN (1) CN110300751A (fr)
MA (1) MA46892A (fr)
TW (1) TW201831453A (fr)
WO (1) WO2018098305A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2747399C2 (ru) 2016-11-28 2021-05-04 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Соли производного индазола и их кристаллы
WO2019225552A1 (fr) * 2018-05-22 2019-11-28 Eisai R&D Management Co., Ltd. Sels de dérivé d'indazole et cristaux associés
WO2020253762A1 (fr) * 2019-06-19 2020-12-24 江苏恒瑞医药股份有限公司 Dérivé d'indazole, son procédé de préparation et son application pharmaceutique
CN116615418A (zh) * 2020-12-18 2023-08-18 江苏恒瑞医药股份有限公司 一种吲唑类衍生物的药学上可接受的盐、结晶形式及其制备方法
CN114644615B (zh) * 2020-12-18 2023-11-14 江苏恒瑞医药股份有限公司 一种吲唑类衍生物的结晶形式及其制备方法
CN114644616B (zh) * 2020-12-18 2023-11-14 江苏恒瑞医药股份有限公司 一种吲唑类衍生物的药学上可接受的盐、结晶形式及其制备方法
WO2023272410A1 (fr) * 2021-06-27 2023-01-05 北京盛诺基医药科技股份有限公司 ANTAGONISTES DE LIAISON COVALENTE DU RÉCEPTEUR ERα
TW202317135A (zh) * 2021-07-13 2023-05-01 大陸商江蘇恒瑞醫藥股份有限公司 選擇性雌激素受體共價拮抗劑與cdk4/6抑制劑聯合在製備治療乳腺癌藥物中的用途
CN115960082B (zh) * 2021-10-13 2024-06-07 长春金赛药业有限责任公司 一种四取代的烯烃化合物、其制备方法及其在医药上的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2483736B (en) * 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
WO2013142266A1 (fr) * 2012-03-20 2013-09-26 Seragon Pharmaceuticals, Inc. Modulateurs de récepteurs d'œstrogènes et leurs utilisations
US9845291B2 (en) * 2014-12-18 2017-12-19 Genentech, Inc. Estrogen receptor modulators and uses thereof
MY186977A (en) * 2015-05-29 2021-08-26 Eisai R&D Man Co Ltd Tetrasubstituted alkene compounds and their use

Also Published As

Publication number Publication date
WO2018098305A1 (fr) 2018-05-31
US20200255415A1 (en) 2020-08-13
JP2019535778A (ja) 2019-12-12
TW201831453A (zh) 2018-09-01
CN110300751A (zh) 2019-10-01
EP3544974A1 (fr) 2019-10-02
US20180141913A1 (en) 2018-05-24

Similar Documents

Publication Publication Date Title
MA46892A (fr) Composés d'alcène tétrasubstitués et leur utilisation pour le traitement du cancer du sein
MA49144A (fr) Polythérapies pour le traitement du cancer
MA45481A (fr) Utilisation d'exosomes pour le traitement de maladies
MA45539A (fr) Dihydropyranopyrimidines pour le traitement d'infections virales
MA50082A (fr) Inhibiteurs d'enpp1 et leur utilisation pour le traitement du cancer
MA45192A (fr) Traitement d'association
MA55697A (fr) Molécules d'anticorps pour le traitement du cancer
MA44083A (fr) Composés de biarylmonobactame pour le traitement d'infections bactériennes
MA55629A (fr) Compositions d'anticorps pour le traitement de tumeurs
MA47310A (fr) Combinaisons de cabozantinib et d'atzolizumab pour traiter le cancer
MA42136A (fr) Anticorps anti-cd38 pour le traitement de l'amyloïdose à chaînes légères et d'autres tumeurs malignes hématologiques positives à cd38
MA52575A (fr) Pansement pour le traitement de la peau endommagée
MA41449A (fr) Polythérapies pour le traitement de cancers
MA48637A (fr) Polythérapies pour le traitement du cancer
MA50409A (fr) Polythérapies pour le traitement du cancer
MA42439A (fr) Agents, utilisations et procédés pour le traitement d'une synucléinopathie
MA43364A (fr) Composés d'alcènes tétrasubstitués et leur utilisation
MA39960A (fr) Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer
MA47719A (fr) Esketamine pour le traitement de la dépression
MA43000A (fr) Polythérapie pour le traitement de tumeurs malignes
MA43811A (fr) Composés d'arylmonobactame bicycliques et leurs méthodes d'utilisation pour le traitement des infections bactériennes
MA55143A (fr) Composés aryl-aniline et hétéroaryl-aniline pour le traitement de cancers de la peau
MA47776A (fr) Polythérapies pour le traitement du cancer du sein
MA52252A (fr) Formulation de poudre nasale pour le traitement de l'hypoglycémie
MA50943A (fr) Anticorps anti-liv1 humanisés pour le traitement du cancer du sein