MA42864B1 - Composes d’éther cyclique-pyrazol-4-yl-heterocyclyl-carboxamide et procédés d'utilisation - Google Patents
Composes d’éther cyclique-pyrazol-4-yl-heterocyclyl-carboxamide et procédés d'utilisationInfo
- Publication number
- MA42864B1 MA42864B1 MA42864A MA42864A MA42864B1 MA 42864 B1 MA42864 B1 MA 42864B1 MA 42864 A MA42864 A MA 42864A MA 42864 A MA42864 A MA 42864A MA 42864 B1 MA42864 B1 MA 42864B1
- Authority
- MA
- Morocco
- Prior art keywords
- cyclic ether
- heterocyclyl
- methods
- pyrazol
- carboxamide compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004122 cyclic group Chemical group 0.000 title 1
- 150000004292 cyclic ethers Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of formula i, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein r2 is a cyclic ether and x is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting pim kinase, and for treating disorders such as cancer mediated by pim kinase. Methods of using compounds of formula i for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705791P | 2012-09-26 | 2012-09-26 | |
| PCT/EP2013/069892 WO2014048939A1 (fr) | 2012-09-26 | 2013-09-25 | Composés d'éther cyclique-pyrazol-4-yl-hétérocyclyl-carboxamide et procédés d'utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA42864A1 MA42864A1 (fr) | 2019-08-30 |
| MA42864B1 true MA42864B1 (fr) | 2020-05-29 |
Family
ID=60450323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA42864A MA42864B1 (fr) | 2012-09-26 | 2013-09-25 | Composes d’éther cyclique-pyrazol-4-yl-heterocyclyl-carboxamide et procédés d'utilisation |
| MA38008A MA38008A1 (fr) | 2012-09-26 | 2013-09-25 | Composés d'éther cyclique-pyrazol-4-yl-hétérocyclyl-carboxamide et procédés d'utilisation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38008A MA38008A1 (fr) | 2012-09-26 | 2013-09-25 | Composés d'éther cyclique-pyrazol-4-yl-hétérocyclyl-carboxamide et procédés d'utilisation |
Country Status (1)
| Country | Link |
|---|---|
| MA (2) | MA42864B1 (fr) |
-
2013
- 2013-09-25 MA MA42864A patent/MA42864B1/fr unknown
- 2013-09-25 MA MA38008A patent/MA38008A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA38008A1 (fr) | 2017-08-31 |
| MA42864A1 (fr) | 2019-08-30 |
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