MA37981B1 - Fibronectin-based scaffold domain proteins that bind to myostatin - Google Patents

Fibronectin-based scaffold domain proteins that bind to myostatin

Info

Publication number
MA37981B1
MA37981B1 MA37981A MA37981A MA37981B1 MA 37981 B1 MA37981 B1 MA 37981B1 MA 37981 A MA37981 A MA 37981A MA 37981 A MA37981 A MA 37981A MA 37981 B1 MA37981 B1 MA 37981B1
Authority
MA
Morocco
Prior art keywords
proteins
myostatin
fibronectin
bind
based scaffold
Prior art date
Application number
MA37981A
Other languages
French (fr)
Other versions
MA37981A1 (en
Inventor
Sharon Cload
Linda Engle
Dasa Lipovsek
Malavi Madireddi
Ginger RAKESTRAW
Joanna Swain
Wenjun Zhao
Hui Wei
Aaron Yamniuk
Vidhyashankar Ramamurthy
Alexander Kozhich
Martin Corbett
Stanley Krystek
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority claimed from PCT/US2013/059458 external-priority patent/WO2014043344A1/en
Publication of MA37981A1 publication Critical patent/MA37981A1/en
Publication of MA37981B1 publication Critical patent/MA37981B1/en

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Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des protéines à domaine d'échafaudage à base de fibronectine qui se lient à la myostatine. L'invention concerne également l'utilisation de ces protéines dans des applications thérapeutiques pour traiter la dystrophie musculaire, la cachexie, la sarcopénie, l'arthrose, l'ostéoporose, le diabète, l'obésité, copd, une néphropathie chronique, l'insuffisance cardiaque, un infarctus du myocarde et une fibrose. L'invention concerne en outre des cellules comportant de telles protéines, des polynucléotides codant pour de telles protéines ou leurs fragments, et des vecteurs comportant les polynucléotides codant pour les protéines.The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications for treating muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, copd, chronic nephropathy, heart failure, myocardial infarction and fibrosis. The invention further provides cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the proteins.

MA37981A 2012-09-13 2013-09-12 Fibronectin-based scaffold domain proteins that bind to myostatin MA37981B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261700697P 2012-09-13 2012-09-13
PCT/US2013/059458 WO2014043344A1 (en) 2012-09-13 2013-09-12 Fibronectin based scaffold domain proteins that bind to myostatin

Publications (2)

Publication Number Publication Date
MA37981A1 MA37981A1 (en) 2017-07-31
MA37981B1 true MA37981B1 (en) 2018-09-28

Family

ID=56117377

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37981A MA37981B1 (en) 2012-09-13 2013-09-12 Fibronectin-based scaffold domain proteins that bind to myostatin

Country Status (2)

Country Link
AR (1) AR094441A1 (en)
MA (1) MA37981B1 (en)

Also Published As

Publication number Publication date
MA37981A1 (en) 2017-07-31
AR094441A1 (en) 2015-08-05

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