AR094441A1 - PROTEINS OF FIBRONECTINE-BASED SUPPORT DOMAIN FIXING MYOSTATIN - Google Patents
PROTEINS OF FIBRONECTINE-BASED SUPPORT DOMAIN FIXING MYOSTATINInfo
- Publication number
- AR094441A1 AR094441A1 ARP130103275A ARP130103275A AR094441A1 AR 094441 A1 AR094441 A1 AR 094441A1 AR P130103275 A ARP130103275 A AR P130103275A AR P130103275 A ARP130103275 A AR P130103275A AR 094441 A1 AR094441 A1 AR 094441A1
- Authority
- AR
- Argentina
- Prior art keywords
- proteins
- myostatin
- domain
- based support
- fibronectine
- Prior art date
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Proteínas del dominio de soporte basadas en fibronectina que se fijan a miostatina. También, uso de estas proteínas en aplicaciones terapéuticas para tratar distrofia muscular, caquexia, sarcopenia, osteoartritis, osteoporosis, diabetes, obesidad, EPOC, nefropatía crónica, insuficiencia cardíaca, infarto de miocardio y fibrosis. También, células que comprenden esas proteínas, polinucleótidos que codifican esas proteínas o fragmentos de estas, y vectores que comprenden los polinucleótidos que codifican las proteínas. Reivindicación 1: Un polipéptido caracterizado porque comprende un dominio de fibronectina tipo III a la décima (¹⁰Fn3), en donde ¹⁰Fn3 tiene al menos un bucle seleccionado de los bucles BC, DE y FG con una secuencia de aminoácidos alterada con respecto a la secuencia del bucle correspondiente del dominio ¹⁰Fn3 humano, y en donde el polipéptido se fija a miostatina con una KD menor de 500 nM.Fibronectin-based support domain proteins that bind to myostatin. Also, use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction and fibrosis. Also, cells comprising those proteins, polynucleotides encoding those proteins or fragments thereof, and vectors comprising the polynucleotides encoding the proteins. Claim 1: A polypeptide characterized in that it comprises a tenth (¹⁰Fn3) type III fibronectin domain, wherein ¹⁰Fn3 has at least one loop selected from the BC, DE and FG loops with an altered amino acid sequence with respect to the sequence of the corresponding loop of the human ¹⁰Fn3 domain, and wherein the polypeptide is fixed to myostatin with a KD of less than 500 nM.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261700697P | 2012-09-13 | 2012-09-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR094441A1 true AR094441A1 (en) | 2015-08-05 |
Family
ID=56117377
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP130103275A AR094441A1 (en) | 2012-09-13 | 2013-09-12 | PROTEINS OF FIBRONECTINE-BASED SUPPORT DOMAIN FIXING MYOSTATIN |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR094441A1 (en) |
MA (1) | MA37981B1 (en) |
-
2013
- 2013-09-12 MA MA37981A patent/MA37981B1/en unknown
- 2013-09-12 AR ARP130103275A patent/AR094441A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
MA37981A1 (en) | 2017-07-31 |
MA37981B1 (en) | 2018-09-28 |
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