AR094441A1 - PROTEINS OF FIBRONECTINE-BASED SUPPORT DOMAIN FIXING MYOSTATIN - Google Patents

PROTEINS OF FIBRONECTINE-BASED SUPPORT DOMAIN FIXING MYOSTATIN

Info

Publication number
AR094441A1
AR094441A1 ARP130103275A ARP130103275A AR094441A1 AR 094441 A1 AR094441 A1 AR 094441A1 AR P130103275 A ARP130103275 A AR P130103275A AR P130103275 A ARP130103275 A AR P130103275A AR 094441 A1 AR094441 A1 AR 094441A1
Authority
AR
Argentina
Prior art keywords
proteins
myostatin
domain
based support
fibronectine
Prior art date
Application number
ARP130103275A
Other languages
Spanish (es)
Inventor
T Cload Sharon
Engle Linda
Lipovsek Dasa
Madireddi Malavi
Chao Rakestraw Ginger
F Swain Joanna
Zhao Wenjun
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR094441A1 publication Critical patent/AR094441A1/en

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Proteínas del dominio de soporte basadas en fibronectina que se fijan a miostatina. También, uso de estas proteínas en aplicaciones terapéuticas para tratar distrofia muscular, caquexia, sarcopenia, osteoartritis, osteoporosis, diabetes, obesidad, EPOC, nefropatía crónica, insuficiencia cardíaca, infarto de miocardio y fibrosis. También, células que comprenden esas proteínas, polinucleótidos que codifican esas proteínas o fragmentos de estas, y vectores que comprenden los polinucleótidos que codifican las proteínas. Reivindicación 1: Un polipéptido caracterizado porque comprende un dominio de fibronectina tipo III a la décima (¹⁰Fn3), en donde ¹⁰Fn3 tiene al menos un bucle seleccionado de los bucles BC, DE y FG con una secuencia de aminoácidos alterada con respecto a la secuencia del bucle correspondiente del dominio ¹⁰Fn3 humano, y en donde el polipéptido se fija a miostatina con una KD menor de 500 nM.Fibronectin-based support domain proteins that bind to myostatin. Also, use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction and fibrosis. Also, cells comprising those proteins, polynucleotides encoding those proteins or fragments thereof, and vectors comprising the polynucleotides encoding the proteins. Claim 1: A polypeptide characterized in that it comprises a tenth (¹⁰Fn3) type III fibronectin domain, wherein ¹⁰Fn3 has at least one loop selected from the BC, DE and FG loops with an altered amino acid sequence with respect to the sequence of the corresponding loop of the human ¹⁰Fn3 domain, and wherein the polypeptide is fixed to myostatin with a KD of less than 500 nM.

ARP130103275A 2012-09-13 2013-09-12 PROTEINS OF FIBRONECTINE-BASED SUPPORT DOMAIN FIXING MYOSTATIN AR094441A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261700697P 2012-09-13 2012-09-13

Publications (1)

Publication Number Publication Date
AR094441A1 true AR094441A1 (en) 2015-08-05

Family

ID=56117377

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130103275A AR094441A1 (en) 2012-09-13 2013-09-12 PROTEINS OF FIBRONECTINE-BASED SUPPORT DOMAIN FIXING MYOSTATIN

Country Status (2)

Country Link
AR (1) AR094441A1 (en)
MA (1) MA37981B1 (en)

Also Published As

Publication number Publication date
MA37981A1 (en) 2017-07-31
MA37981B1 (en) 2018-09-28

Similar Documents

Publication Publication Date Title
UY35027A (en) PROTEINS OF FIBRONECTINE-BASED SUPPORT DOMAIN FIXING MYOSTATIN
AR080229A1 (en) FIBRONECTINE ARMAZON DOMAIN PROTEINS THAT JOIN IL -23 (INTERLEUCINE 23)
CY1122539T1 (en) GLUCAGON ANALOGUES
AR092076A1 (en) HOMODIMERIC PROTEINS
CY1116099T1 (en) CANCER Fusion Protein
EA201590525A1 (en) SLIP PROTEINS FOR THE TREATMENT OF METABOLIC SYNDROME
AR071874A1 (en) ARMAZON DOMAIN PROTEINS BASED ON MULTIVALENT FIBRONECTINE
AR074399A1 (en) BESPECIFIC MOLECULES OF UNION TO EGFR / IGFIR
BR112013029409A2 (en) "peptide product comprising peptide covalently linked surfactant, pharmaceutical composition comprising it, as well as use of peptide product in the treatment of condition associated with insulin resistance, cardiovascular disease and diabetes"
CY1121466T1 (en) ANTIBODIES AGAINST B1 VRADYKININ RECEPTORS
AR076670A1 (en) SPECIFIC HUMANIZED ANTIBODIES OF THE PROTOFIBRILLARY FORM OF THE BETA-AMYLOID PEPTIDE.
AR081454A1 (en) FIBRONECTINE-BASED ARMAZON DOMAIN PROTEINS THAT JOIN PCSK9 (KEXINA SUBTILISINE CONVERTASE CONVERTASE 9)
PE20211272A1 (en) IL-22 POLYPEPTIDES AND IL-22 Fc FUSION PROTEINS AND METHODS OF USE
PE20170771A1 (en) COMPOSITIONS AND METHODS OF USE TO TREAT METABOLIC DISORDERS
EA201590545A1 (en) POLYPEPTIDES CONTAINING FC WITH CHANGED GLYCOSYLATION AND REDUCED EFFECTOR FUNCTION
MX2015014538A (en) Trimeric antigen binding molecules.
CL2015003199A1 (en) Therapeutic peptides
BR112018073511A2 (en) glucagon receptor selective polypeptides and methods of use
ECSP15042898A (en) PEPTIDES AND COMPOSITIONS FOR THE TREATMENT OF JOINT DAMAGE
CL2013003688A1 (en) Glucagon / glp-1 receptor coagonist peptide; conjugate of said peptide; pharmaceutical composition; use of the peptide to treat a disease selected from the group of metabolic syndrome, diabetes, obesity, liver steatosis and a neurodegenerative disease.
EA201291234A1 (en) ANALOGUE GLUACAGONA
PA8738401A1 (en) EXENDINE FUSION PROTEINS
BR112014017165A8 (en) chimeric factor viii polypeptides and their uses
EA201400811A1 (en) DOUBLE ANTIGEN-INDUCED TWO-COMPONENT FUNCTIONAL COMPLEMENTATION
AR091866A1 (en) GLUCAGON ANALOGS

Legal Events

Date Code Title Description
FG Grant, registration