MA31941B1 - Bis-pyridylpyridones en tant qu'antagonistes du récepteur 1 de l'hormone de concentration de la mélanine - Google Patents

Bis-pyridylpyridones en tant qu'antagonistes du récepteur 1 de l'hormone de concentration de la mélanine

Info

Publication number
MA31941B1
MA31941B1 MA32956A MA32956A MA31941B1 MA 31941 B1 MA31941 B1 MA 31941B1 MA 32956 A MA32956 A MA 32956A MA 32956 A MA32956 A MA 32956A MA 31941 B1 MA31941 B1 MA 31941B1
Authority
MA
Morocco
Prior art keywords
pyridylpyridones
antagonists
hormone receptor
bis
melanin concentration
Prior art date
Application number
MA32956A
Other languages
English (en)
Inventor
Scott Allen
Iii William C Blackwell
Eric Boros
Jon L Collins
Don Hertzog
Xi Liang
John Ray
Steven Michael Reister
Vicente Samano
Ron Sherrill
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA31941B1 publication Critical patent/MA31941B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVELLES BIS-PYRIDYLPYRIDONES QUI SONT DES ANTAGONISTES DU RÉCEPTEUR 1 DE L'HORMONE DE CONCENTRATION DE LA MÉLANINE (MCHR1), DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, LEURS PROCÉDÉS DE PRÉPARATION ET LEUR UTILISATION EN THÉRAPIE ET POUR LE TRAITEMENT DE L'OBÉSITÉ ET/OU DU DIABÈTE.
MA32956A 2007-12-10 2010-06-25 Bis-pyridylpyridones en tant qu'antagonistes du récepteur 1 de l'hormone de concentration de la mélanine MA31941B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1252507P 2007-12-10 2007-12-10

Publications (1)

Publication Number Publication Date
MA31941B1 true MA31941B1 (fr) 2010-12-01

Family

ID=40469812

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32956A MA31941B1 (fr) 2007-12-10 2010-06-25 Bis-pyridylpyridones en tant qu'antagonistes du récepteur 1 de l'hormone de concentration de la mélanine

Country Status (15)

Country Link
US (1) US20110118261A1 (fr)
EP (1) EP2231646A1 (fr)
JP (1) JP2011506462A (fr)
KR (1) KR20100117059A (fr)
CN (1) CN102015684A (fr)
AU (1) AU2008335187B2 (fr)
CA (1) CA2708741A1 (fr)
CO (1) CO6280470A2 (fr)
CR (1) CR11562A (fr)
EA (1) EA201070725A1 (fr)
IL (1) IL206237A0 (fr)
MA (1) MA31941B1 (fr)
MX (1) MX2010006388A (fr)
WO (1) WO2009076387A1 (fr)
ZA (1) ZA201004010B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012528871A (ja) * 2009-06-03 2012-11-15 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー メラニン凝集ホルモン受容体１アンタゴニストとしてのビス−ピリジルピリドン類
US20120077794A1 (en) * 2009-06-03 2012-03-29 Glaxsmithkline Llc Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists
CN107082783B (zh) 2012-01-26 2019-03-22 H.隆德贝克有限公司 具有咪唑并三嗪酮骨架的pde9抑制剂
AU2013302497A1 (en) 2012-08-16 2015-03-05 The Scripps Research Institute Novel kappa opioid ligands
CN103044394A (zh) * 2012-12-20 2013-04-17 北京理工大学 一种苯基氨基嘧啶衍生物及其制备方法和用途
AU2018234931B2 (en) * 2017-03-17 2022-05-26 Blackthorn Therapeutics, Inc. Kappa opioid receptor antagonists and products and methods related thereto
MX2019014406A (es) 2017-06-01 2020-01-30 Sumitomo Chemical Co Compuesto heterociclico y composicion que contiene el mismo.
WO2020048828A1 (fr) 2018-09-03 2020-03-12 Bayer Pharma Aktiengesellschaft Composés du 5-hétéroaryl-3,9-diazaspiro[5.5]undécane
WO2020048830A1 (fr) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft Composés 5-aryl-3,9-diazaspiro[5.5]undécan-2-one
WO2020048831A1 (fr) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft Composés 5-aryl-3,9-diazaspiro[5.5]undécan-2-one
CN109851542A (zh) * 2019-01-28 2019-06-07 爱斯特（成都）生物制药股份有限公司 一种(s)-n-甲基-n-(吡咯烷-3-基)乙酰胺二盐酸盐及其合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005219784B2 (en) * 2004-03-05 2010-09-02 Msd K.K. Pyridone derivative

Also Published As

Publication number Publication date
KR20100117059A (ko) 2010-11-02
JP2011506462A (ja) 2011-03-03
EA201070725A1 (ru) 2011-02-28
CA2708741A1 (fr) 2009-06-18
WO2009076387A1 (fr) 2009-06-18
ZA201004010B (en) 2011-03-30
AU2008335187A1 (en) 2009-06-18
CN102015684A (zh) 2011-04-13
AU2008335187B2 (en) 2012-03-29
EP2231646A1 (fr) 2010-09-29
US20110118261A1 (en) 2011-05-19
MX2010006388A (es) 2010-06-25
CR11562A (es) 2010-09-23
IL206237A0 (en) 2010-12-30
CO6280470A2 (es) 2011-05-20

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