MA31384B1 - Nouvelles molécules d'anticorps et d'acides nucléiques se fixant à la protéine hsp90 de stress fongique - Google Patents
Nouvelles molécules d'anticorps et d'acides nucléiques se fixant à la protéine hsp90 de stress fongiqueInfo
- Publication number
- MA31384B1 MA31384B1 MA32355A MA32355A MA31384B1 MA 31384 B1 MA31384 B1 MA 31384B1 MA 32355 A MA32355 A MA 32355A MA 32355 A MA32355 A MA 32355A MA 31384 B1 MA31384 B1 MA 31384B1
- Authority
- MA
- Morocco
- Prior art keywords
- nucleic acid
- acid molecules
- stress protein
- novel antibody
- protein hsp90
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention porte sur un peptide scfv comprenant un domaine vh et un domaine vl liés par un espaceur d'acide aminé. Le domaine vh comprend une séquence présentant au moins 80 % d'identité avec la séquence seq id no 64. Le domaine vl comprend une séquence présentant au moins 80 % d'identité avec la séquence seq id no 66. Le peptide scfv comprend également la substitution ou la délation d'un acide aminé du domaine vh à la position correspondant à c28.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07107140 | 2007-04-27 | ||
EP07113353 | 2007-07-27 | ||
PCT/EP2008/055006 WO2008132134A1 (fr) | 2007-04-27 | 2008-04-24 | Nouvelles molécules d'anticorps et d'acides nucléiques se fixant à la protéine hsp90 de stress fongique |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31384B1 true MA31384B1 (fr) | 2010-05-03 |
Family
ID=39717534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32355A MA31384B1 (fr) | 2007-04-27 | 2009-11-20 | Nouvelles molécules d'anticorps et d'acides nucléiques se fixant à la protéine hsp90 de stress fongique |
Country Status (21)
Country | Link |
---|---|
US (3) | US20100113355A1 (fr) |
EP (2) | EP2144932A1 (fr) |
JP (1) | JP2010524485A (fr) |
KR (1) | KR20100017387A (fr) |
CN (1) | CN101679517A (fr) |
AR (1) | AR066311A1 (fr) |
AU (1) | AU2008244308A1 (fr) |
BR (1) | BRPI0810827A2 (fr) |
CA (1) | CA2685136A1 (fr) |
CL (1) | CL2008001202A1 (fr) |
CR (1) | CR11059A (fr) |
EA (1) | EA200901441A1 (fr) |
EC (1) | ECSP099765A (fr) |
GT (1) | GT200900276A (fr) |
IL (1) | IL201445A0 (fr) |
MA (1) | MA31384B1 (fr) |
MX (1) | MX2009011595A (fr) |
PE (1) | PE20090728A1 (fr) |
TN (1) | TN2009000442A1 (fr) |
TW (1) | TW200902714A (fr) |
WO (2) | WO2008132134A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100113355A1 (en) | 2007-04-27 | 2010-05-06 | Naresh Chennamsetty | Novel antibody molecules and nucleic acids binding to fungal stress protein hsp90 |
CA2956161A1 (fr) * | 2014-07-23 | 2016-01-28 | Ohio State Innovation Foundation | Methodes et compositions associees a des fragments d'anticorps qui se lient a la glycoproteine 72 associee aux tumeurs (tag 72) |
CN105652011B (zh) * | 2014-11-20 | 2017-09-22 | 深圳市安群生物工程有限公司 | 检测人HSP90α‑2蛋白的荧光免疫层析试纸及其制备方法 |
CN113845591B (zh) * | 2018-10-30 | 2023-10-31 | 迈威(上海)生物科技股份有限公司 | Hsp90抗体及其在抗真菌感染中的应用 |
WO2024040194A1 (fr) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditionnement pour l'ingénierie de cellules immunitaires in vivo |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4732852A (en) * | 1981-11-20 | 1988-03-22 | Cetus Corporation | Site directed peptidase cleavage |
US4670382A (en) | 1983-12-02 | 1987-06-02 | Temple University--of the Commonwealth System of Higher Education | Monoclonal antibody to Candida albicans cytoplasmic antigens and methods of preparing same |
US4806465A (en) * | 1984-01-16 | 1989-02-21 | Temple University Of The Commonwealth System Of Higher Education | Cytoplasmic antigens of candida albicans and methods of using the same |
GB8506373D0 (en) | 1985-03-12 | 1985-04-11 | Axon Healthcare Ltd | Antigens antibodies |
GB8915019D0 (en) * | 1989-06-30 | 1989-08-23 | Matthews Ruth C | Medicaments |
EP0861893A3 (fr) | 1991-09-19 | 1999-11-10 | Genentech, Inc. | Expression de haut niveau d'immunoglobulines |
GB2270076A (en) | 1992-08-18 | 1994-03-02 | Univ Manchester | Human HSP 90 Epitopes |
CA2370007A1 (fr) | 1999-04-09 | 2000-10-19 | Sloan-Kettering Institute For Cancer Research | Procedes et compositions permettant la degradation et/ou l'inhibition des tyrosine kinases appartenant a la famille her |
WO2001055174A2 (fr) | 2000-01-25 | 2001-08-02 | Oklahoma Medical Research Foundation | Procedure universelle de repliement de proteines de recombinaison |
GB0008305D0 (en) * | 2000-04-06 | 2000-05-24 | Neutec Pharma Plc | Treatment of fungal infections |
WO2002006990A1 (fr) | 2000-07-14 | 2002-01-24 | Healthcite, Inc. | Procede et systeme pour fournir des informations medicales |
WO2002069900A2 (fr) | 2001-03-01 | 2002-09-12 | Conforma Therapeutics Corp. | Procede de traitement de troubles proliferatifs d'origine genetique par des inhibiteurs de hsp90 |
GB0127983D0 (en) | 2001-11-22 | 2002-01-16 | Neutec Pharma Plc | Treatment of micro-organism infection |
GB0315111D0 (en) | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
GB0409077D0 (en) | 2004-04-23 | 2004-05-26 | Neutec Pharma Plc | Treatment of fungal infections |
RU2389507C2 (ru) * | 2004-07-02 | 2010-05-20 | Ньютек Фарма Плс | Лечение рака |
US20100113355A1 (en) | 2007-04-27 | 2010-05-06 | Naresh Chennamsetty | Novel antibody molecules and nucleic acids binding to fungal stress protein hsp90 |
WO2008132174A1 (fr) | 2007-04-27 | 2008-11-06 | Novartis Ag | Composition d'immunoglobulines |
-
2006
- 2006-04-24 US US12/597,229 patent/US20100113355A1/en not_active Abandoned
-
2008
- 2008-04-24 MX MX2009011595A patent/MX2009011595A/es unknown
- 2008-04-24 WO PCT/EP2008/055006 patent/WO2008132134A1/fr active Application Filing
- 2008-04-24 JP JP2010504689A patent/JP2010524485A/ja active Pending
- 2008-04-24 CN CN200880013913A patent/CN101679517A/zh active Pending
- 2008-04-24 EA EA200901441A patent/EA200901441A1/ru unknown
- 2008-04-24 EP EP08736541A patent/EP2144932A1/fr not_active Withdrawn
- 2008-04-24 US US12/150,076 patent/US7722869B2/en not_active Expired - Fee Related
- 2008-04-24 EP EP08749716A patent/EP2152746A1/fr not_active Withdrawn
- 2008-04-24 BR BRPI0810827-7A2A patent/BRPI0810827A2/pt not_active Application Discontinuation
- 2008-04-24 AU AU2008244308A patent/AU2008244308A1/en not_active Abandoned
- 2008-04-24 CA CA002685136A patent/CA2685136A1/fr not_active Abandoned
- 2008-04-24 KR KR1020097024646A patent/KR20100017387A/ko not_active Application Discontinuation
- 2008-04-24 WO PCT/EP2008/055037 patent/WO2008132152A1/fr active Application Filing
- 2008-04-25 AR ARP080101768A patent/AR066311A1/es unknown
- 2008-04-25 TW TW097115380A patent/TW200902714A/zh unknown
- 2008-04-25 CL CL2008001202A patent/CL2008001202A1/es unknown
- 2008-04-25 PE PE2008000709A patent/PE20090728A1/es not_active Application Discontinuation
-
2009
- 2009-10-09 CR CR11059A patent/CR11059A/es not_active Application Discontinuation
- 2009-10-11 IL IL201445A patent/IL201445A0/en unknown
- 2009-10-23 GT GT200900276A patent/GT200900276A/es unknown
- 2009-10-23 TN TNP2009000442A patent/TN2009000442A1/fr unknown
- 2009-11-20 MA MA32355A patent/MA31384B1/fr unknown
- 2009-11-27 EC EC2009009765A patent/ECSP099765A/es unknown
-
2010
- 2010-03-08 US US12/719,049 patent/US20100166758A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2008132134A1 (fr) | 2008-11-06 |
CA2685136A1 (fr) | 2008-11-06 |
CR11059A (es) | 2009-11-20 |
US20100166758A1 (en) | 2010-07-01 |
AR066311A1 (es) | 2009-08-12 |
WO2008132152A1 (fr) | 2008-11-06 |
US7722869B2 (en) | 2010-05-25 |
CN101679517A (zh) | 2010-03-24 |
EP2144932A1 (fr) | 2010-01-20 |
WO2008132134A9 (fr) | 2009-07-09 |
TW200902714A (en) | 2009-01-16 |
EA200901441A1 (ru) | 2010-04-30 |
US20090136484A1 (en) | 2009-05-28 |
IL201445A0 (en) | 2010-06-16 |
GT200900276A (es) | 2010-05-21 |
JP2010524485A (ja) | 2010-07-22 |
PE20090728A1 (es) | 2009-07-02 |
TN2009000442A1 (en) | 2011-03-31 |
US20100113355A1 (en) | 2010-05-06 |
BRPI0810827A2 (pt) | 2014-10-29 |
CL2008001202A1 (es) | 2008-12-19 |
ECSP099765A (es) | 2009-12-28 |
AU2008244308A1 (en) | 2008-11-06 |
MX2009011595A (es) | 2009-12-08 |
EP2152746A1 (fr) | 2010-02-17 |
KR20100017387A (ko) | 2010-02-16 |
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