MA30813B1 - Derives de 2-pyridinecarboxamide ayant un effet d'activation sur la gk. - Google Patents
Derives de 2-pyridinecarboxamide ayant un effet d'activation sur la gk.Info
- Publication number
- MA30813B1 MA30813B1 MA31819A MA31819A MA30813B1 MA 30813 B1 MA30813 B1 MA 30813B1 MA 31819 A MA31819 A MA 31819A MA 31819 A MA31819 A MA 31819A MA 30813 B1 MA30813 B1 MA 30813B1
- Authority
- MA
- Morocco
- Prior art keywords
- formula
- aliphatic
- cycle
- atom
- nitrogenic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'INVENTION CONCERNE UN COMPOSÉ REPRÉSENTÉ PAR LA FORMULE (I) OU UN SEL ACCEPTABLE DU POINT DE VUE PHARMACEUTIQUE DE CELUI-CI, LEQUEL A UNE ACTIVITÉ D'ACTIVATION DE LA GLUCOKINASE ET EST PAR CONSÉQUENT UTILE POUR LE TRAITEMENT DU DIABÈTE OU DE L'OBÉSITÉ. (I) [DANS LA FORMULE R1 ET R2 REPRÉSENTENT CHACUN INDÉPENDAMMENT UN GROUPE ALKYLE INFÉRIEUR ; ET X1 REPRÉSENTE UN GROUPE REPRÉSENTÉ PAR LA FORMULE (II-1) : (II-1) OÙ R11 ET R12 REPRÉSENTENT CHACUN INDÉPENDAMMENT UN ATOME D'HYDROGÈNE OU UN GROUPE ALKYLE INFÉRIEUR OU BIEN R11 ET R12 PEUVENT FORMER AVEC UN ATOME D'AZOTE AUQUEL R11 ET R12 SONT LIÉS UN CYCLE ALIPHATIQUE AZOTÉ AYANT 4 À 7 CHAÎNONS (L'UN DES ATOMES DE CARBONE CONSTITUANT LE CYCLE ALIPHATIQUE AZOTÉ AYANT 4 À 7 CHAÎNONS POUVANT ÊTRE SUBSTITUÉ PAR UN ATOME D'OXYGÈNE) OU BIEN R11 ET R12 PEUVENT FORMER AVEC N'IMPORTE QUEL ATOME DE CARBONE PRÉSENT DANS LE GROUPE (CH2)M UN CYCLE ALIPHATIQUE AZOTÉ AYANT 4 À 7 CHAÎNONS OU SIMILAIRE ; ET M REPRÉSENTE UN NOMBRE ENTIER CHOISI 1 PARMI 3.]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006275824 | 2006-10-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30813B1 true MA30813B1 (fr) | 2009-10-01 |
Family
ID=39282963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31819A MA30813B1 (fr) | 2006-10-06 | 2009-04-24 | Derives de 2-pyridinecarboxamide ayant un effet d'activation sur la gk. |
Country Status (22)
Country | Link |
---|---|
US (1) | US8338460B2 (fr) |
EP (1) | EP2077266B1 (fr) |
JP (1) | JP5292100B2 (fr) |
KR (1) | KR20090060426A (fr) |
CN (1) | CN101522673A (fr) |
AR (1) | AR063028A1 (fr) |
AU (1) | AU2007307560B2 (fr) |
BR (1) | BRPI0716590A2 (fr) |
CA (1) | CA2667068C (fr) |
CL (1) | CL2007002890A1 (fr) |
CO (1) | CO6180507A2 (fr) |
CR (1) | CR10673A (fr) |
GT (1) | GT200900065A (fr) |
IL (1) | IL197714A0 (fr) |
MA (1) | MA30813B1 (fr) |
MX (1) | MX2009003073A (fr) |
NO (1) | NO20091793L (fr) |
PE (1) | PE20081195A1 (fr) |
RU (1) | RU2009117209A (fr) |
SV (1) | SV2009003196A (fr) |
TW (1) | TW200831504A (fr) |
WO (1) | WO2008044777A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ540791A (en) * | 2003-02-13 | 2009-09-25 | Banyu Pharma Co Ltd | Novel 2-pyridinecarboxamide derivatives |
AR063028A1 (es) | 2006-10-06 | 2008-12-23 | Banyu Pharma Co Ltd | Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen. |
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
WO2009063821A1 (fr) | 2007-11-12 | 2009-05-22 | Banyu Pharmaceutical Co., Ltd. | Dérivé d'hétéroaryloxy quinazoline |
CA2733646A1 (fr) | 2008-08-15 | 2010-02-18 | Banyu Pharmaceutical Co., Ltd. | Derive acetyle pyrrolidinyle indole |
EP2328892B1 (fr) * | 2008-08-29 | 2013-01-16 | Msd K.K. | Dérivé d'oxotétrahydrofurann-2-yl-benzimidazole |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
WO2011157827A1 (fr) | 2010-06-18 | 2011-12-22 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
WO2013045413A1 (fr) | 2011-09-27 | 2013-04-04 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
US9527838B2 (en) | 2012-12-17 | 2016-12-27 | Merck Sharp & Dohme Corp. | 2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment |
CN113045546A (zh) * | 2021-03-25 | 2021-06-29 | 浙江天宇药业股份有限公司 | 一种吡咯替尼杂质、其制备方法及用途 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3630200A (en) | 1969-06-09 | 1971-12-28 | Alza Corp | Ocular insert |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
GB2277930A (en) | 1993-05-11 | 1994-11-16 | Shell Int Research | Herbicidal picolinamide derivatives |
US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
SE0102300D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE519859C2 (sv) | 2001-08-17 | 2003-04-15 | Novacast Ab | Anordning för behandling av järnlegeringar i ett kärl |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
DE60328671D1 (de) * | 2002-03-26 | 2009-09-17 | Banyu Pharma Co Ltd | Neue aminobenzamidderivate |
NZ540791A (en) * | 2003-02-13 | 2009-09-25 | Banyu Pharma Co Ltd | Novel 2-pyridinecarboxamide derivatives |
KR20050105488A (ko) | 2003-02-26 | 2005-11-04 | 반유 세이야꾸 가부시끼가이샤 | 헤테로아릴카바모일벤젠 유도체 |
NZ544756A (en) | 2003-07-22 | 2009-09-25 | Astex Therapeutics Ltd | 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
WO2005042524A1 (fr) | 2003-10-30 | 2005-05-12 | Virochem Pharma Inc. | Carboxamide de pyridine et methodes permettant d'inhiber l'integrase du vih |
US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
GB0412468D0 (en) | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
KR100716891B1 (ko) | 2005-11-01 | 2007-05-09 | (주)아모레퍼시픽 | 피리딘 티아졸 카복사마이드 유도체, 이의 제조방법 및이를 함유하는 피부 미백용 조성물 |
US7951824B2 (en) | 2006-02-17 | 2011-05-31 | Hoffman-La Roche Inc. | 4-aryl-pyridine-2-carboxyamide derivatives |
EP1849785A1 (fr) | 2006-04-28 | 2007-10-31 | Neuropharma, S.A. | Dérivés de N-(2-Thiazolyl)-amide en tant qu'inhibiteurs de GSK-3 |
AR063028A1 (es) | 2006-10-06 | 2008-12-23 | Banyu Pharma Co Ltd | Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen. |
-
2007
- 2007-09-27 AR ARP070104280A patent/AR063028A1/es not_active Application Discontinuation
- 2007-10-04 PE PE2007001346A patent/PE20081195A1/es not_active Application Discontinuation
- 2007-10-05 AU AU2007307560A patent/AU2007307560B2/en not_active Ceased
- 2007-10-05 CL CL2007002890A patent/CL2007002890A1/es unknown
- 2007-10-05 EP EP07829750A patent/EP2077266B1/fr active Active
- 2007-10-05 CN CNA2007800374154A patent/CN101522673A/zh active Pending
- 2007-10-05 JP JP2008538775A patent/JP5292100B2/ja not_active Expired - Fee Related
- 2007-10-05 CA CA2667068A patent/CA2667068C/fr not_active Expired - Fee Related
- 2007-10-05 TW TW096137610A patent/TW200831504A/zh unknown
- 2007-10-05 RU RU2009117209/04A patent/RU2009117209A/ru not_active Application Discontinuation
- 2007-10-05 MX MX2009003073A patent/MX2009003073A/es active IP Right Grant
- 2007-10-05 BR BRPI0716590-0A patent/BRPI0716590A2/pt not_active IP Right Cessation
- 2007-10-05 US US11/973,240 patent/US8338460B2/en active Active
- 2007-10-05 KR KR1020097006965A patent/KR20090060426A/ko not_active Application Discontinuation
- 2007-10-05 WO PCT/JP2007/070014 patent/WO2008044777A1/fr active Application Filing
-
2009
- 2009-03-19 CR CR10673A patent/CR10673A/es unknown
- 2009-03-19 IL IL197714A patent/IL197714A0/en unknown
- 2009-03-19 CO CO09028706A patent/CO6180507A2/es not_active Application Discontinuation
- 2009-03-20 SV SV2009003196A patent/SV2009003196A/es not_active Application Discontinuation
- 2009-03-20 GT GT200900065A patent/GT200900065A/es unknown
- 2009-04-24 MA MA31819A patent/MA30813B1/fr unknown
- 2009-05-05 NO NO20091793A patent/NO20091793L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP5292100B2 (ja) | 2013-09-18 |
MX2009003073A (es) | 2009-04-02 |
AU2007307560A1 (en) | 2008-04-17 |
KR20090060426A (ko) | 2009-06-12 |
SV2009003196A (es) | 2009-07-28 |
EP2077266A4 (fr) | 2010-07-07 |
EP2077266A1 (fr) | 2009-07-08 |
GT200900065A (es) | 2010-04-28 |
JPWO2008044777A1 (ja) | 2010-02-18 |
AR063028A1 (es) | 2008-12-23 |
CO6180507A2 (es) | 2010-07-19 |
CR10673A (es) | 2009-09-03 |
US20080090799A1 (en) | 2008-04-17 |
IL197714A0 (en) | 2009-12-24 |
CN101522673A (zh) | 2009-09-02 |
EP2077266B1 (fr) | 2012-07-25 |
BRPI0716590A2 (pt) | 2012-12-25 |
RU2009117209A (ru) | 2010-11-20 |
NO20091793L (no) | 2009-05-05 |
PE20081195A1 (es) | 2008-09-04 |
US8338460B2 (en) | 2012-12-25 |
CL2007002890A1 (es) | 2008-01-18 |
WO2008044777A1 (fr) | 2008-04-17 |
CA2667068C (fr) | 2012-03-27 |
AU2007307560B2 (en) | 2012-10-04 |
TW200831504A (en) | 2008-08-01 |
CA2667068A1 (fr) | 2008-04-17 |
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