MA27905A1 - Pyrazolines utilisees comme antagonistes par-1 pour traiter des maladies cardio-vasculaires - Google Patents
Pyrazolines utilisees comme antagonistes par-1 pour traiter des maladies cardio-vasculairesInfo
- Publication number
- MA27905A1 MA27905A1 MA28710A MA28710A MA27905A1 MA 27905 A1 MA27905 A1 MA 27905A1 MA 28710 A MA28710 A MA 28710A MA 28710 A MA28710 A MA 28710A MA 27905 A1 MA27905 A1 MA 27905A1
- Authority
- MA
- Morocco
- Prior art keywords
- pyrazolines
- treatment
- cardiovascular diseases
- par
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des pyrazolines de formule (I) dans laquelle E désigne méthylène, NH désigne un atome d'oxygène ou un atome de soufre, R2 désigne un groupe de formule (II). L'invention concerne également des procédé permettant de produire lesdites pyrazolines et leur utilisation pour préparer des médicaments utilisés dans le traitement et/ou la prophylaxie de pathologies, notamment de maladies cardio-vasculaires, comme par ex. des maladies thromboemboliques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10331951 | 2003-07-15 | ||
DE102004010545A DE102004010545A1 (de) | 2003-07-15 | 2004-03-04 | Pyrazoline |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27905A1 true MA27905A1 (fr) | 2006-05-02 |
Family
ID=34081645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28710A MA27905A1 (fr) | 2003-07-15 | 2006-01-06 | Pyrazolines utilisees comme antagonistes par-1 pour traiter des maladies cardio-vasculaires |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1648447A1 (fr) |
AU (1) | AU2004257406A1 (fr) |
BR (1) | BRPI0412554A (fr) |
CA (1) | CA2532316A1 (fr) |
MA (1) | MA27905A1 (fr) |
MX (1) | MXPA06000507A (fr) |
NO (1) | NO20060733L (fr) |
WO (1) | WO2005007157A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004061748A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Azetidin-substituierte Pyrazoline |
DE102004061751A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Cyanoguanidin-substituierte Pyrazoline |
DE102004061747A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Thiophen-substituierte Pyrazoline |
CA2969771A1 (fr) * | 2014-12-08 | 2016-06-16 | Bayer Pharma Aktiengesellschaft | Nouveaux composes d'aryl-cyanoguanidine |
WO2016166186A1 (fr) | 2015-04-17 | 2016-10-20 | Bayer Pharma Aktiengesellschaft | Nouveaux composés d'aryl-cyanoguanidine |
US20180118722A1 (en) * | 2015-04-17 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Novel aryl-cyanoguanidine compounds |
EP3109237A1 (fr) | 2015-06-22 | 2016-12-28 | AnaMar AB | Nouveaux antagonistes de 5-ht2 |
CN111892585A (zh) * | 2020-08-05 | 2020-11-06 | 杭州维坦医药科技有限公司 | 作为p2x3受体拮抗剂的n-甲酰胺基吡唑啉类衍生物及应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69131899T2 (de) * | 1990-07-13 | 2000-08-17 | Rohm & Haas | N-Aryl-3-aryl-4-substituierte-4,5-dihydro-1H-pyrazol-1-carboxamide und Verfahren zu deren Herstellung |
DE4217863A1 (de) * | 1991-08-28 | 1993-03-04 | Bayer Ag | Substituierte pyrazoline |
DE4217862A1 (de) * | 1991-08-28 | 1993-03-04 | Bayer Ag | Substituierte pyrazoline |
DE4217864A1 (de) * | 1992-05-29 | 1993-12-02 | Bayer Ag | Substituierte Pyrazoline |
DE4233713A1 (de) * | 1992-10-07 | 1994-04-14 | Bayer Ag | Substituierte 4,5-Dihydro-1-pyrazolcarbonsäureanilide |
-
2004
- 2004-07-02 CA CA002532316A patent/CA2532316A1/fr not_active Abandoned
- 2004-07-02 EP EP04740582A patent/EP1648447A1/fr not_active Withdrawn
- 2004-07-02 WO PCT/EP2004/007227 patent/WO2005007157A1/fr not_active Application Discontinuation
- 2004-07-02 MX MXPA06000507A patent/MXPA06000507A/es unknown
- 2004-07-02 BR BRPI0412554-1A patent/BRPI0412554A/pt not_active Application Discontinuation
- 2004-07-02 AU AU2004257406A patent/AU2004257406A1/en not_active Abandoned
-
2006
- 2006-01-06 MA MA28710A patent/MA27905A1/fr unknown
- 2006-02-15 NO NO20060733A patent/NO20060733L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2532316A1 (fr) | 2005-01-27 |
EP1648447A1 (fr) | 2006-04-26 |
WO2005007157A1 (fr) | 2005-01-27 |
MXPA06000507A (es) | 2006-04-05 |
BRPI0412554A (pt) | 2006-09-19 |
AU2004257406A1 (en) | 2005-01-27 |
NO20060733L (no) | 2006-04-10 |
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