LV14031B - Cranberry and lingonberry tablets and method for producing thereof - Google Patents

Abstract

The invention relates to the pharmaceutical industry, Para-pharmaceutical product industry and food industry, and issues affecting the development of compositions that are natural source of vitamins, trace elements and fibers. Purpose of the invention is to develop biologically active compositions for the form of tablets that are composed of cranberries and red bilberries preserved native (unaltered) form. In addition, in cranberry and lingonberry berries existing valuable substances can maintain over a long period, incorporating them in tablet form. Thus making it more convenient use, easy to use, easy packaged, transported and relatively cheap (economical), as well as access through the year, i.e., much longer period in comparison with fresh berries. The target reaches based on the fact that the composition contains cranberry and lingonberry marc powders that are components of peel, pulp and seeds, and excipients in certain relationships (mass %). Composition is obtained by drying cranberry and lingonberry berries at the temperature up to 40 oC. After drying the bled consists of granules, pellets then set up the press in tablets.

Description

Description of the Invention

The invention relates to the pharmaceutical, parapharmaceutical and food industries and concerns the development of a composition which is a natural source of vitamins, trace elements and fiber.

Cranberries (Oxycoccus palustris) contain pectic substances and are obtained by extraction with dilute acids. Pectic substances bind toxins, helping to decontaminate the body. They have anti-inflammatory, ulcer-healing and digestive-enhancing physiological function, as well as anti-diarrheal properties. Cranberries also have adsorptive properties associated with the pectic substances contained therein,

Pectic substances are a group of polysaccharides whose structure is based on galacturonic acid, its salts and its methyl esters. Water-soluble pectic substances are of medical importance. With sugar and acids, they form gels. Pectic gels have pronounced anti-inflammatory and adsorptive properties. Pectic substances have been shown to bind strontium, cobalt and even their radioactive isotopes, and most pectic substances are not used by the body and are excreted together with harmful substances. At the same time, pectic substances improve the digestion of food, prevent decomposition of the intestines, poison the toxic substances, both from the outside and from the body itself, promote the action of microorganisms, especially those that synthesize group B vitamins. Animal studies have shown that they also bind salts of lead and mercury and promote their elimination from the body. Pectic substances are a preparation of hemophobin, which is used to stop bleeding.

Cranberries also contain vitamin K, or phytomenadione, also called anti-haemorrhagic vitamin, which is a vital coagulation factor.

Cranberries contain benzoic acid and citric acid. Benzoic acid is used in medicine as an antiseptic for skin diseases. Benzoic acid esters are used in perfumes because of their pleasant smell. Benzoic acid and its derivatives are widely used in organic synthesis for the production of dyes and medical preparations.

Citric acid is one of the most common organic acids in nature. Citric acid is used as a food additive for lemonades, juices, sweets, dry sparkling beverage concentrates; it is also added to medicines, used in cosmetics. Citric acid is added to dye solutions in colored fabric printing.

Cranberries have anti-inflammatory and anti-inflammatory, anti-bacterial, urate-lowering, urinary, adsorbing, refreshing properties and are a source of vitamins].

Cranberries are rich in flavonoids and antioxidants, which have a beneficial effect on cardiovascular health and reduce the risk of atherosclerosis, reduce the inflammatory response of atherosclerosis in blood vessels (arteries and vein walls); contributes to the development of age-related degenerative diseases (Alzheimer's and Parkinson's syndromes) and possesses anti-carcinogenic properties. Cranberries are low in calories but rich in biologically active substances, they are an excellent natural source of organic acids.

When using cranberries, the pH of the urine becomes more acidic, and the cranberries contain a substance with an antibacterial effect, hyperuric acid. The antibacterial properties in the urinary tract are explained by the fact that the cranberry proanthocyanidins are different in structure from the proanthocyanidins found in apples, green tea and grapes. Proanthocyanidin A 1 prevents the penetration of deeper tissues of the Herpes simplex virus (HSV - 2), which causes genital herpes. Cranberries contain quinic acid, which is not broken down in the body and is excreted unchanged in the urine. The use of these berries can reduce the formation of stones in the urinary tract by acidifying the urine. Cranberries also speed up the removal of magnesium and potassium, which can reduce the chances of urinary tract formation. With normal amounts of cranberry juice, patients with kidney stones provide 50% of the calcium excreted in urine [2l.

Lingonberries (Vaccinium vitis -idaea). The lingonberry plants are closely related to the heather family. Some researchers consider the lingonberry family to be a descendant of the heather family. Most of the plants in this family are shrubs and semi-shrubs. The fruit is a succulent berry, or more rarely, a pupa. There are 35 genera and 800 species. Most of them grow wild in North and South America.

Lingonberries contain sugars and organic acids (benzoic, citric, etc.), tannins and glycosides. Berries should be well preserved fresh. The lingonberries are used to make jams and are used in the confectionery industry.

Phytoncides contained in lingonberry berries act on staphylococci. Lingonberry berries are also used in respiratory diseases such as pneumonia in the recovery phase as a promoter of regeneration [1].

The greatest amount of nutrients are found in fresh cranberry and lingonberry berries at the stage of ripeness. However, berries and the substances they contain can also be preserved if they are obtained from juice, berries can also be dried or frozen, so that the positive effects of cranberries on the body can be used at least throughout the year.

A biologically active composition of herbal ingredients containing a powder mix of cranberry, lingonberry, black elderberry and rhubarb is known. The proposed composition is prepared as follows: berries and herbs are dried and ground from 0.1 to 0.5 mm. The ingredients are mixed according to the recipe and packaged [3].

Known use of cranberry and lingonberry extracts in the preparation of biologically active additives (BAP). Extracts of these berries contain antioxidants, polyphenols and flavonoids such as anticyanin, proanthocyaninine and quercetin [4,5,6,7,8,9].

Known use of cranberry extract in paradontosis and gum disease,

The use of a cranberry-containing preparation for the treatment of salmonellosis is known [l 1],

There is a known use of cranberries and lingonberries in the probiotic composition as an enteric stabilizer [12].

There is a known composition of cranberries and lactoferrin which is used in case of urinary tract infection, especially in case of antibiotic intolerance [13].

Known use of a complex composition of cranberries and lingonberries in the treatment of inflammatory diseases and arthritis as well as in Alzheimer's disease [14],

Known use of cranberry juice as an antiallergic component [15].

A known biological active composition in liquid form, obtained by extraction of cranberry and lingonberry berries with glycerol at 20 to 30 ° C for 30 to 40 days. Propolis and water are then added to the glycerol extract. The known composition expands the body's strengthening and toning range of natural products [16],

Known tablet composition consists of ascorbic acid, cranberries, sugar, steric acid, flavor (cranberry or lingonberry extract), colorant and potato starch [17].

All of the aforementioned compositions have various therapeutic, tonic, general strengthening and immunity-boosting properties, which are indicated separately for each of the aforementioned compositions.

The object of the present invention is to provide a biologically active composition in the form of a tablet containing cranberries and lingonberries in their native state, which can be preserved in the unaltered state:

PP vitamin, which is an important active component of ascorbic acid uptake and vascular protection; flavonoids, which strengthen and increase the strength and elasticity of blood vessels;

trace elements - potassium, iodine and magnesium;

B vitamins that are important for strengthening the nervous system; help actively reduce fatigue and improve brain function; decrease the amount of 'harmful' cholesterol in the blood;

decrease high blood pressure;

improve intestinal microflora and reduce the possibility of inflammation;

protect tooth enamel against plaque, protect teeth against caries and gums against inflammation and paradontosis; improves the condition of the urinary microflora, enhances urine propulsion properties, while maintaining potassium in the body and eliminating toxins; demonstrates a cure for cystitis;

beneficial effect on the skin and hair, improves their shine and elasticity. In addition, the valuable substances contained in cranberry and lingonberry berries can be preserved for a longer period of time when incorporated into tablets. Thus making them usable throughout the year - much longer, convenient, easy to use, easy to pack, transport and relatively cheap (economical) compared to fresh berries.

The stated objective is achieved by the formation of a tablet containing cranberry dry powder with seeds, lingonberry powder with seeds, starch, cellulose, stearates, distilled

water in proportions of the following components, w / w: cranberry powder with seeds 1 to 99% lingonberry powder with seeds 1 to 99% starch 5 to 25% pulp 2.5 to 15% stearates 0.5 to 5% distilled water the rest of

Cranberry and lingonberry berries are squeezed under pressure, the berry juice is squeezed, the resulting pulp is air-dried, ground, sieved through a sieve, the starch is added to the pulp, and the resulting powder is added with starch paste, mechanically squeezed through a sieve the resulting granules are dried in a stream, then ground to a powdery consistency, pulp and stearate are added to the powder mass, mixed to a homogeneous mass, and tablets are prepared.

In addition, cranberry and lingonberry berries are squeezed at a pressure of 200 to 500 bar, the berry juice is separated and the resulting mass is dried at a temperature of +37 to + 43 ° C with an air flow rate of 700 to 1200 m3 / h up to humidity 2, 5 to 7.5%, grind the mass obtained at 6000 to 10 000 rpm, sift through a sieve of 0,1 to 0,3 mm, add starch to the ground, mix at 25 to 40 rpm. until the mass becomes homogeneous, 5 to 10% starch paste is added to the mass of the powder, the mass is mechanically squeezed through a sieve of 0.8 to 1.2 mm, the granules are prepared, the obtained granules are dried in a stream at a temperature of + 37 ° C to + 43 ° C. , 5 to 7.5%., Granulate at 6000 to 10,000 rpm. until the powder has a consistency which passes through a sieve with a mesh of 0,1 to 0,3 mm, pulp and stearate are added to the powder, mixed to a homogeneous mass, and tablets are prepared.

Example 1-2

To prepare the tablet take:

cranberry powder with seeds 1 to 99% lingonberry powder with seeds 1 to 99% starch 5 to 25% pulp 2.5 to 15% stearates 0.5 to 5% distilled water the rest of

Cranberry and lingonberry berries are squeezed by direct pressing using a juicer. Pressure from 200 to 500 bar. After extraction, the berry juice is separated and the extrudates remain - bark, pulp and seeds.

Berry presses are dried in a flow-through oven at a temperature of + 40 ° ± 3 ° C at an air flow rate of 700 to 1200 m3 / h. to humidity 2.5 to 7.5%. Choice of drying temperature regime: as close as possible to the temperature of the human body in order not to facilitate the decomposition of valuable components.

Milling mills at mill speeds from 6000 to 10,000 rpm. up to a particle size of 0.1 to 0.3 mm through a sieve. The resulting mass is milled in a mill at 6000 to 10,000 rpm. Add 5 to 10% by weight of starch to the ground mass and stir in a rotary mixer at 25 to 45 rpm for one hour until homogenous. Check homogeneity by titration of a sample of the mixture (determined as% of starch).

The powder mass is moistened with 5 to 10% starch paste. The pellets are prepared mechanically by squeezing the pulp through a sieve of 0.8 to 1.2 mm.

The obtained pellets are dried on trays in a flow-through oven at a temperature from +37 to + 43 ° C with an air flow rate of 700 to 1200 m3 / h. to humidity 2.5 to 7.5%.

After the pellets are dried, the pellets are ground in a mill at 6000 to 10,000 rpm. to a powdery consistency which passes through a sieve of 0,1 to 0,3 mm. Add the pulp and stearate to the powder and stir in the rotary mixer for 1 hour. Made pills.

Tablets made according to the formula and formula of the invention allow to maintain the natural properties of cranberry and lingonberry berry seed. The resulting composition has healing, toning, general strengthening and immunity enhancing properties. All biologically active components are preserved in their native (unchanged) state and can be preserved for a prolonged period of 5 years.

Control of the finished tablets can be achieved by extraction, by chemical-analytical methods or by spectrophotometric determination of flavonoids in the extract: anticyanin, proanthociaminine and quercetin.

Sources of information

1. A.Skutelis, D. Pakalns. Medicinal plant pharmacology. Riga 2005.

2. Fred. J. Bandelin. Compressed Tablets by Wet Granulation. Pharmaceutical Dosage Forms - tablets / edited by Herbert A.Lieberman, Leon Lachman, Joseph B. Schwartz. - 2nd ed., Rev. and expand. Marcel Dekker, Inc. 1989, 131-193.

3. Pat. Ru 2321275, C2, A61 KJ 36 / 00,2008.

4. Pat. Fr.2880541, Al, 2006, A61 K36 / 03.

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6. Pat. US 2007/0292539, Al, 2007, A61K36 / 45.

7. Pat. US 2008/0118625, Al, 2008, A23L 1/10; A23P 1/12.

8. Pat. US 2008/0254135, Al, 2008, A61K36 / 73.

9. Pat. US 2008/0254110, Al, 2008, A61K 36/00.

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13. Pat. WO 2008/018111, A2,2008, A61K 36/45.

14. Pat. WO 2007/024901, Al, 2007, A61K36 / 73.

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17. Pat. RU 2006 119 151, A, 2006, A61K31 / 00.

Claims (3)

1. A tablet containing cranberries and lingonberries, characterized in that it contains cranberry dry powder with seeds, dry lingonberry powder, starch, cellulose, stearates, distilled water in the following percentages by weight: cranberry powder with seeds 1 to 99% lingonberry powder with seeds 1 to 99% starch 5 to 25% pulp 2.5 to 15% stearates 0.5 to 5% distilled water the rest of 2. A process for the preparation of a tablet according to claim 1 comprising cranberries and lingonberries, characterized in that the cranberries and lingonberries are squeezed under pressure, the berry juice is squeezed, the resulting mass is air-dried, ground, sieved through a sieve. starch and mix to a homogeneous mass, add the starch paste to the mass of the powder obtained, mechanically squeeze the mass through a sieve, dry the resulting granules to a powdery consistency, add pulp and stearate to the mass, mix to form a homogeneous mass. 3. A process for the preparation of a tablet according to claim 2, comprising cranberries and lingonberries, characterized in that the cranberries and lingonberries are squeezed at a pressure of 200 to 500 bar, the berry juice is separated, and the resulting mass is dried at a temperature from +37 to + 43 ° C, with an air flow at a speed of 700 to 1200 m3 / h, a moisture content of 2.5 to 7.5%, the resulting mass is milled at a speed of 6000 to 10 000 rpm, sieved through a sieve of 0,1 to 0, 3 mm, add the starch to the ground mass and mix at 25 to 40 rpm. until the mass becomes homogeneous, 5 to 10% starch paste is added to the mass of the powder, the mass is mechanically squeezed through a sieve of 0.8 to 1.2 mm, the granules are prepared, the obtained granules are dried in a stream at a temperature of + 37 ° C to + 43 ° C. , 5 to 7.5%., Granulate at 6000 to 10,000 rpm. to a powder consistency which passes through a sieve of 0,1 to 0,3 mm, add pulp and stearate to the powder, mix to a homogeneous mass, and make tablets.