LV11993B - Peptīdi un to iegūšanas paņēmiens - Google Patents
Peptīdi un to iegūšanas paņēmiens Download PDFInfo
- Publication number
- LV11993B LV11993B LVP-97-186A LV970186A LV11993B LV 11993 B LV11993 B LV 11993B LV 970186 A LV970186 A LV 970186A LV 11993 B LV11993 B LV 11993B
- Authority
- LV
- Latvia
- Prior art keywords
- trp
- nval
- tyr
- ala
- pro
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 claims abstract description 15
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 claims abstract description 14
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims abstract description 14
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims abstract description 14
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 claims abstract description 14
- KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 claims abstract description 13
- -1 di-substituted amide Chemical class 0.000 claims abstract description 13
- AGPKZVBTJJNPAG-RFZPGFLSSA-N D-Isoleucine Chemical compound CC[C@@H](C)[C@@H](N)C(O)=O AGPKZVBTJJNPAG-RFZPGFLSSA-N 0.000 claims abstract description 12
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims abstract description 12
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 claims abstract description 10
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims abstract description 8
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 claims abstract description 8
- 125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 claims abstract description 8
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims abstract description 8
- 239000002253 acid Substances 0.000 claims abstract 6
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract 5
- 150000001413 amino acids Chemical class 0.000 claims abstract 2
- 150000008064 anhydrides Chemical class 0.000 claims abstract 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-M 6-aminohexanoate Chemical compound NCCCCCC([O-])=O SLXKOJJOQWFEFD-UHFFFAOYSA-M 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 229960002684 aminocaproic acid Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract 2
- 230000004957 immunoregulator effect Effects 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- LEHPJMKVGFPSSP-ZQINRCPSSA-N Ile-Glu-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(O)=O)=CNC2=C1 LEHPJMKVGFPSSP-ZQINRCPSSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- QJCNLJWUIOIMMF-YUMQZZPRSA-N (2s,3s)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)OC(C)(C)C QJCNLJWUIOIMMF-YUMQZZPRSA-N 0.000 description 1
- 102100025191 Cyclin-A2 Human genes 0.000 description 1
- LLEUXCDZPQOJMY-AAEUAGOBSA-N Glu-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CCC(O)=O)N)C(O)=O)=CNC2=C1 LLEUXCDZPQOJMY-AAEUAGOBSA-N 0.000 description 1
- 101000934320 Homo sapiens Cyclin-A2 Proteins 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 241001191378 Moho Species 0.000 description 1
- 108010050025 alpha-glutamyltryptophan Proteins 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU95102461A RU2107691C1 (ru) | 1995-03-02 | 1995-03-02 | Пептид и способ его получения |
| PCT/RU1996/000046 WO1996026955A1 (fr) | 1995-03-02 | 1996-02-28 | Peptide et son procede d'obtention |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LV11993A LV11993A (lv) | 1998-03-20 |
| LV11993B true LV11993B (lv) | 1998-05-20 |
Family
ID=20164981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LVP-97-186A LV11993B (lv) | 1995-03-02 | 1997-10-02 | Peptīdi un to iegūšanas paņēmiens |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6051683A (da) |
| EP (1) | EP0818462B1 (da) |
| JP (1) | JP3902226B2 (da) |
| CN (1) | CN1161373C (da) |
| AT (1) | ATE306495T1 (da) |
| AU (1) | AU708084B2 (da) |
| BR (1) | BR9607901A (da) |
| CA (1) | CA2214410C (da) |
| CZ (1) | CZ288418B6 (da) |
| DE (1) | DE69635272T2 (da) |
| DK (1) | DK0818462T3 (da) |
| ES (1) | ES2250984T3 (da) |
| HK (1) | HK1012859A1 (da) |
| HU (1) | HUP0000320A3 (da) |
| LT (1) | LT4393B (da) |
| LV (1) | LV11993B (da) |
| RU (1) | RU2107691C1 (da) |
| SK (1) | SK282604B6 (da) |
| UA (1) | UA51647C2 (da) |
| WO (1) | WO1996026955A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159940A (en) * | 1996-02-28 | 2000-12-12 | Immunotech Developments Inc. | Method for modulating hemopoiesis |
| DE19712633A1 (de) * | 1997-03-26 | 1998-10-08 | Laves Arzneimittel | Verwendung von gamma-Aminobuttersäure als Interleukinbildungsstimulans |
| IL137820A (en) * | 2000-08-10 | 2009-06-15 | S I S Shulov Inst For Science | Pharmaceutical composition for topical administration comprising an analgesic peptide |
| EP1343805A4 (en) * | 2000-10-06 | 2005-07-20 | Xenoport Inc | COMPOUNDS DERIVED FROM GALLENIC ACIDS FOR THE PROVISION OF CONTINUING SYSTEMIC CONCENTRATIONS OF MEDICINAL PRODUCTS AFTER ORAL ADMINISTRATION |
| US20020098999A1 (en) * | 2000-10-06 | 2002-07-25 | Gallop Mark A. | Compounds for sustained release of orally delivered drugs |
| AU2002239257A1 (en) * | 2000-11-17 | 2002-06-03 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| JP2005501013A (ja) * | 2001-06-11 | 2005-01-13 | ゼノポート，インコーポレイテッド | Ｇａｂａ類似体の全身濃度が持続するアミノ酸コンジュゲート |
| EP1865950B1 (en) | 2005-04-07 | 2013-08-28 | Centre National de la Recherche Scientifique | Compounds useful as modulators of the proteasome activity |
| CA2571645A1 (en) | 2006-12-19 | 2008-06-19 | Apotex Technologies Inc. | Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture |
| CA2706525C (en) * | 2007-11-20 | 2012-05-01 | Immunotech Developments Inc. | Novel immunoregulatory peptides, compositions, and uses thereof |
| CN102724998A (zh) | 2009-08-10 | 2012-10-10 | 伊姆诺科技发展公司 | 用于引发特异性免疫应答以治疗病毒感染和其他病症的具有肽佐剂的疫苗 |
| RU2458935C1 (ru) * | 2011-02-18 | 2012-08-20 | Общество с ограниченной ответственностью "ЦитоНИР" (ООО "ЦитоНИР") | Средство для коррекции метаболического синдрома |
| EP2818477B1 (de) * | 2012-05-18 | 2016-05-04 | Obshestvo S Organichennoj Otvetstvennostju "CytoNIR" | L-lysyl-l-glutamyl-l-tryptophan zur korrektur des stoffwechselsyndroms |
| RU2540496C1 (ru) * | 2014-01-20 | 2015-02-10 | Общество с ограниченной ответственностью "ПРОМОМЕД" | Композиция для назального применения, лекарственное средство на его основе и способ его пременения |
| EA025690B1 (ru) * | 2014-07-15 | 2017-01-30 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Ранозаживляющее средство, обладающее иммуностимулирующим и антиоксидантным эффектами |
| RU2672888C1 (ru) | 2018-04-18 | 2018-11-20 | Пивипи Лабс Пте. Лтд. | Противовирусное иммунотропное средство для лечения ОРВИ |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3100974A1 (de) * | 1980-01-18 | 1982-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente enthaltende arzneimittel mit immunregulierender wirkung, und thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente |
| HU185263B (en) * | 1981-06-12 | 1984-12-28 | Richter Gedeon Vegyeszet | Process for producing peptides effective on the immuncontroll analogous with the tp5 |
| JPS609182Y2 (ja) * | 1981-06-18 | 1985-04-02 | アルファレコ−ド株式会社 | カセツトテ−プケ−スマガジン |
| HU184481B (en) * | 1981-10-02 | 1984-08-28 | Richter Gedeon Vegyeszet | Process for producing tripeptides for diminishing appetite |
| US4699897A (en) * | 1983-06-04 | 1987-10-13 | Amgen | Biologically active peptides structurally related to regions within growth hormones |
| US4603121A (en) * | 1983-10-06 | 1986-07-29 | G. D. Searle & Co. | Enkephalin analogs |
| IT1172391B (it) * | 1983-12-23 | 1987-06-18 | Polifarma Spa | Composti tirpeptidici contenenti acido piroglutaminico e triptofano,procedimentio di produzione ed applicazioni terapeutiche |
| CH659586A5 (de) | 1985-07-02 | 1987-02-13 | Le G Ped I | Arzneimittel aus dem thymus und verfahren zu dessen herstellung. |
| US5070076A (en) * | 1985-07-02 | 1991-12-03 | Leningradsky Gosudarstvenny Pedagogichesky Institut | Thymus-gland preparation and method for producing same |
| CA1286989C (en) | 1985-12-26 | 1991-07-30 | A. Arthur Gottlieb | Immunoamplifiers and related compositions |
| US4751216A (en) * | 1985-12-26 | 1988-06-14 | Imreg, Inc. | Methods for treating AIDS and ARC |
| IT1216908B (it) * | 1987-03-19 | 1990-03-14 | Eniricerche Spa | Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche. |
| WO1989006134A1 (en) | 1987-12-30 | 1989-07-13 | Vsesojuzny Kardiologichesky Nauchny Tsentr Akademi | Pharmaceutical preparation for treating immunodeficiency conditions |
| HU201095B (en) * | 1988-06-14 | 1990-09-28 | Richter Gedeon Vegyeszet | New peptides inhibiting the activity of the immune system and pharmaceutical compositions comprising same, as well as process for producing these peptides and compositions |
| GB2231051B (en) * | 1989-05-05 | 1992-12-16 | Erba Carlo Spa | Bombesin antagonists |
| WO1992009628A1 (en) * | 1990-11-23 | 1992-06-11 | Immunodynamics, Inc. | Synthetic immunoactive peptides having immunomodulating and therapeutic activities |
| DE69230500D1 (de) * | 1991-10-28 | 2000-02-03 | Cytran Ltd | Pharmazeutische Dipeptid Zusammensetzungen und Verwendungsmethoden. |
| IT1264129B1 (it) * | 1993-04-09 | 1996-09-16 | Codev S A | Peptidi ad attivita' immunomodulatoria derivati da frammenti di leucochinina |
| WO1995003067A1 (en) * | 1993-07-21 | 1995-02-02 | Khavinson Vladimir Khatskelevi | Pharmaceutical with immunomodulating activity |
| RU2107692C1 (ru) * | 1995-06-07 | 1998-03-27 | Дейгин Владислав Исакович | Пептид и способ его получения |
| RU2067000C1 (ru) * | 1994-06-29 | 1996-09-27 | Владислав Исакович Дейгин | Пептид и способ его получения |
-
1995
- 1995-03-02 RU RU95102461A patent/RU2107691C1/ru active
-
1996
- 1996-02-28 US US08/894,963 patent/US6051683A/en not_active Expired - Lifetime
- 1996-02-28 CA CA002214410A patent/CA2214410C/en not_active Expired - Fee Related
- 1996-02-28 UA UA97104869A patent/UA51647C2/uk unknown
- 1996-02-28 DK DK96906117T patent/DK0818462T3/da active
- 1996-02-28 EP EP96906117A patent/EP0818462B1/en not_active Expired - Lifetime
- 1996-02-28 BR BR9607901-0A patent/BR9607901A/pt not_active Application Discontinuation
- 1996-02-28 JP JP52618596A patent/JP3902226B2/ja not_active Expired - Fee Related
- 1996-02-28 AU AU49594/96A patent/AU708084B2/en not_active Ceased
- 1996-02-28 HU HU0000320A patent/HUP0000320A3/hu unknown
- 1996-02-28 ES ES96906117T patent/ES2250984T3/es not_active Expired - Lifetime
- 1996-02-28 CZ CZ19972703A patent/CZ288418B6/cs not_active IP Right Cessation
- 1996-02-28 WO PCT/RU1996/000046 patent/WO1996026955A1/ru active IP Right Grant
- 1996-02-28 CN CNB961923172A patent/CN1161373C/zh not_active Expired - Fee Related
- 1996-02-28 SK SK1180-97A patent/SK282604B6/sk not_active IP Right Cessation
- 1996-02-28 DE DE69635272T patent/DE69635272T2/de not_active Expired - Lifetime
- 1996-02-28 AT AT96906117T patent/ATE306495T1/de active
-
1997
- 1997-10-02 LT LT97-158A patent/LT4393B/lt not_active IP Right Cessation
- 1997-10-02 LV LVP-97-186A patent/LV11993B/lv unknown
-
1998
- 1998-12-10 HK HK98113125A patent/HK1012859A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9607901A (pt) | 1999-09-08 |
| ES2250984T3 (es) | 2006-04-16 |
| DE69635272T2 (de) | 2006-07-20 |
| HUP0000320A2 (hu) | 2000-08-28 |
| HUP0000320A3 (en) | 2000-10-30 |
| RU95102461A (ru) | 1996-12-20 |
| EP0818462B1 (en) | 2005-10-12 |
| ATE306495T1 (de) | 2005-10-15 |
| LV11993A (lv) | 1998-03-20 |
| UA51647C2 (uk) | 2002-12-16 |
| RU2107691C1 (ru) | 1998-03-27 |
| AU4959496A (en) | 1996-09-18 |
| CA2214410C (en) | 2001-05-29 |
| CN1185160A (zh) | 1998-06-17 |
| US6051683A (en) | 2000-04-18 |
| DK0818462T3 (da) | 2006-02-27 |
| EP0818462A1 (en) | 1998-01-14 |
| HK1012859A1 (en) | 1999-08-13 |
| EP0818462A4 (en) | 2000-05-31 |
| LT97158A (en) | 1998-05-25 |
| SK282604B6 (sk) | 2002-10-08 |
| JPH11505515A (ja) | 1999-05-21 |
| DE69635272D1 (de) | 2006-02-23 |
| AU708084B2 (en) | 1999-07-29 |
| CZ288418B6 (en) | 2001-06-13 |
| CN1161373C (zh) | 2004-08-11 |
| JP3902226B2 (ja) | 2007-04-04 |
| CA2214410A1 (en) | 1996-09-06 |
| SK118097A3 (en) | 1998-04-08 |
| LT4393B (lt) | 1998-10-26 |
| CZ270397A3 (cs) | 1998-05-13 |
| WO1996026955A1 (fr) | 1996-09-06 |
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