LU87188A1 - Association de derives de pyrimidine et de derives d'uree et/ou d'allantoine pour induire et stimuler la croissance des cheveux et diminuer leur chute - Google Patents
Association de derives de pyrimidine et de derives d'uree et/ou d'allantoine pour induire et stimuler la croissance des cheveux et diminuer leur chute Download PDFInfo
- Publication number
- LU87188A1 LU87188A1 LU87188A LU87188A LU87188A1 LU 87188 A1 LU87188 A1 LU 87188A1 LU 87188 A LU87188 A LU 87188A LU 87188 A LU87188 A LU 87188A LU 87188 A1 LU87188 A1 LU 87188A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- allantoin
- formula
- weight
- acid
- physiologically acceptable
- Prior art date
Links
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical class NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 title claims description 33
- 230000003779 hair growth Effects 0.000 title claims description 10
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title claims description 3
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title description 13
- 230000001939 inductive effect Effects 0.000 title description 2
- 230000004936 stimulating effect Effects 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims abstract description 66
- 150000003230 pyrimidines Chemical class 0.000 claims abstract description 18
- 210000004209 hair Anatomy 0.000 claims abstract description 14
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 11
- 239000001257 hydrogen Substances 0.000 claims abstract description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 7
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 7
- 125000002877 alkyl aryl group Chemical group 0.000 claims abstract description 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 5
- 125000003118 aryl group Chemical group 0.000 claims abstract description 4
- 210000004761 scalp Anatomy 0.000 claims abstract description 4
- 125000004948 alkyl aryl alkyl group Chemical group 0.000 claims abstract description 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 3
- 125000002034 haloarylalkyl group Chemical group 0.000 claims abstract description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 3
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 17
- 229960000458 allantoin Drugs 0.000 claims description 17
- 201000004384 Alopecia Diseases 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 13
- 229960003632 minoxidil Drugs 0.000 claims description 9
- 239000004202 carbamide Substances 0.000 claims description 8
- 208000024963 hair loss Diseases 0.000 claims description 8
- 230000003676 hair loss Effects 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 8
- 231100000360 alopecia Toxicity 0.000 claims description 6
- 239000002537 cosmetic Substances 0.000 claims description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims description 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 4
- 229920002230 Pectic acid Polymers 0.000 claims description 4
- 125000000129 anionic group Chemical group 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 229940055726 pantothenic acid Drugs 0.000 claims description 4
- 239000011713 pantothenic acid Substances 0.000 claims description 4
- 239000010318 polygalacturonic acid Substances 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- -1 alkylene glycols Chemical class 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 125000003386 piperidinyl group Chemical group 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- DCFWIZFONLVPKL-KSSASCOMSA-N (2,5-dioxoimidazolidin-4-yl)urea;(2s,3r,4s,5r)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound NC(=O)NC1NC(=O)NC1=O.OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O DCFWIZFONLVPKL-KSSASCOMSA-N 0.000 claims description 2
- PCWYUXROTNZZHR-IHMBCTQLSA-N (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylic acid;(2,5-dioxoimidazolidin-4-yl)urea Chemical compound NC(=O)NC1NC(=O)NC1=O.C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C PCWYUXROTNZZHR-IHMBCTQLSA-N 0.000 claims description 2
- DCWBLFMYZJBXPI-UFLZEWODSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid;(2,5-dioxoimidazolidin-4-yl)urea Chemical compound NC(=O)NC1NC(=O)NC1=O.N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 DCWBLFMYZJBXPI-UFLZEWODSA-N 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 2
- AATPBWFUUDJROH-UHFFFAOYSA-K NC1=CC=C(C(=O)[O-])C=C1.OCl.[Al+3].NC1=CC=C(C(=O)[O-])C=C1.NC1=CC=C(C(=O)[O-])C=C1 Chemical compound NC1=CC=C(C(=O)[O-])C=C1.OCl.[Al+3].NC1=CC=C(C(=O)[O-])C=C1.NC1=CC=C(C(=O)[O-])C=C1 AATPBWFUUDJROH-UHFFFAOYSA-K 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000002535 acidifier Substances 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 125000005055 alkyl alkoxy group Chemical group 0.000 claims description 2
- 150000005215 alkyl ethers Chemical class 0.000 claims description 2
- 229960004050 aminobenzoic acid Drugs 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 125000002393 azetidinyl group Chemical group 0.000 claims description 2
- 125000004069 aziridinyl group Chemical group 0.000 claims description 2
- QXNDZONIWRINJR-UHFFFAOYSA-N azocane Chemical compound C1CCCNCCC1 QXNDZONIWRINJR-UHFFFAOYSA-N 0.000 claims description 2
- NRHDCQLCSOWVTF-UHFFFAOYSA-N azonane Chemical compound C1CCCCNCCC1 NRHDCQLCSOWVTF-UHFFFAOYSA-N 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- RKHUXMOKLPDAKM-KLXURFKVSA-N calcium;3-[[(2r)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid;(2,5-dioxoimidazolidin-4-yl)urea Chemical compound [Ca+2].NC(=O)NC1NC(=O)NC1=O.OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O RKHUXMOKLPDAKM-KLXURFKVSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000008139 complexing agent Substances 0.000 claims description 2
- KVMXOJPUIDZOEN-UHFFFAOYSA-L disodium;butanedioate;(2,5-dioxoimidazolidin-4-yl)urea Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O.NC(=O)NC1NC(=O)NC1=O KVMXOJPUIDZOEN-UHFFFAOYSA-L 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- 239000003349 gelling agent Substances 0.000 claims description 2
- 125000004634 hexahydroazepinyl group Chemical group N1(CCCCCC1)* 0.000 claims description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
- 235000019161 pantothenic acid Nutrition 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- NNCOOIBIVIODKO-UHFFFAOYSA-N aluminum;hypochlorous acid Chemical compound [Al].ClO NNCOOIBIVIODKO-UHFFFAOYSA-N 0.000 claims 2
- 230000003113 alkalizing effect Effects 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- 239000002280 amphoteric surfactant Substances 0.000 claims 1
- 239000003945 anionic surfactant Substances 0.000 claims 1
- 239000003093 cationic surfactant Substances 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 229940118257 zinc undecylenate Drugs 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 235000019441 ethanol Nutrition 0.000 description 10
- 239000002609 medium Substances 0.000 description 8
- 230000002335 preservative effect Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003797 telogen phase Effects 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 230000003698 anagen phase Effects 0.000 description 2
- 201000002996 androgenic alopecia Diseases 0.000 description 2
- LVYZJEPLMYTTGH-UHFFFAOYSA-H dialuminum chloride pentahydroxide dihydrate Chemical compound [Cl-].[Al+3].[OH-].[OH-].[Al+3].[OH-].[OH-].[OH-].O.O LVYZJEPLMYTTGH-UHFFFAOYSA-H 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 150000003672 ureas Chemical class 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- DBGSRZSKGVSXRK-UHFFFAOYSA-N 1-[2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]acetyl]-3,6-dihydro-2H-pyridine-4-carboxylic acid Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CCC(=CC1)C(=O)O DBGSRZSKGVSXRK-UHFFFAOYSA-N 0.000 description 1
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 description 1
- LWNZJCOLRQMXHS-UHFFFAOYSA-N 2-acetamido-4-methylsulfanylbutanoic acid;(2,5-dioxoimidazolidin-4-yl)urea Chemical compound NC(=O)NC1NC(=O)NC1=O.CSCCC(C(O)=O)NC(C)=O LWNZJCOLRQMXHS-UHFFFAOYSA-N 0.000 description 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- ZIMGGGWCDYVHOY-UHFFFAOYSA-N 3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine Chemical compound N=C1N(O)C(N)=CC(N2CCCCC2)=N1 ZIMGGGWCDYVHOY-UHFFFAOYSA-N 0.000 description 1
- 208000003024 Diffuse alopecia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920002305 Schizophyllan Polymers 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- RJZNFXWQRHAVBP-UHFFFAOYSA-I aluminum;magnesium;pentahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Al+3] RJZNFXWQRHAVBP-UHFFFAOYSA-I 0.000 description 1
- 206010068168 androgenetic alopecia Diseases 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 239000002610 basifying agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- WSXUSPUOGYVCQV-UHFFFAOYSA-N n,n-diethylpyrimidin-2-amine Chemical compound CCN(CC)C1=NC=CC=N1 WSXUSPUOGYVCQV-UHFFFAOYSA-N 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU87188A LU87188A1 (fr) | 1988-03-31 | 1988-03-31 | Association de derives de pyrimidine et de derives d'uree et/ou d'allantoine pour induire et stimuler la croissance des cheveux et diminuer leur chute |
| EP89400822A EP0336813B1 (de) | 1988-03-31 | 1989-03-23 | Assoziat bestehend aus Pyrimidin-Derivaten und Harnstoff- und/oder Allantoin-Derivaten zum Induzieren und Stimulieren des Haarwuchses und zum Vermindern des Haarausfalles |
| DE8989400822T DE68903125T2 (de) | 1988-03-31 | 1989-03-23 | Assoziat bestehend aus pyrimidin-derivaten und harnstoff- und/oder allantoin-derivaten zum induzieren und stimulieren des haarwuchses und zum vermindern des haarausfalles. |
| AT89400822T ATE81281T1 (de) | 1988-03-31 | 1989-03-23 | Assoziat bestehend aus pyrimidin-derivaten und harnstoff- und/oder allantoin-derivaten zum induzieren und stimulieren des haarwuchses und zum vermindern des haarausfalles. |
| JP1076859A JPH01287014A (ja) | 1988-03-31 | 1989-03-30 | 頭髪の生長を誘発及び刺激しそして頭髪の損失を減らすための、ピリミジン誘導体と尿素及び／またはアラントイン誘導体との組み合わせ物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU87188 | 1988-03-31 | ||
| LU87188A LU87188A1 (fr) | 1988-03-31 | 1988-03-31 | Association de derives de pyrimidine et de derives d'uree et/ou d'allantoine pour induire et stimuler la croissance des cheveux et diminuer leur chute |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU87188A1 true LU87188A1 (fr) | 1989-10-26 |
Family
ID=19731037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU87188A LU87188A1 (fr) | 1988-03-31 | 1988-03-31 | Association de derives de pyrimidine et de derives d'uree et/ou d'allantoine pour induire et stimuler la croissance des cheveux et diminuer leur chute |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0336813B1 (de) |
| JP (1) | JPH01287014A (de) |
| AT (1) | ATE81281T1 (de) |
| DE (1) | DE68903125T2 (de) |
| LU (1) | LU87188A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2718018B1 (fr) * | 1994-04-05 | 1996-04-26 | Oreal | Composition cosmétique et/ou dermatologique à support hydrophile et vitamine C mélangeables extemporanément. |
| JPH0853327A (ja) * | 1994-06-10 | 1996-02-27 | Toshihiro Matsumoto | アラントインまたはその誘導体による養毛・育毛剤 |
| FR2834209B1 (fr) * | 2001-12-31 | 2004-04-23 | Oreal | Compositions cosmetiques comprenant un actif cosmetique et un systeme ligand-recepteur exogene du cheveu et procede de traitement des cheveux utilisant ces compositions |
| FR2838640B1 (fr) * | 2002-04-19 | 2006-02-24 | Oreal | Composition cosmetique comprenant un actif cosmetique et un systeme ligand-recepteur exogene fixe de facon covalente aux cheveux et procede de traitement des cheveux utilisant cette composition |
| JP5622187B2 (ja) * | 2009-09-08 | 2014-11-12 | 群泰生物科技股▲ふん▼有限公司 | 水溶性ミノキシジル組成物 |
| FR2953722B1 (fr) | 2009-12-16 | 2012-03-09 | Expanscience Lab | Composition comprenant au moins un sucre en c7 pour le traitement de l'alopecie, pour le traitement cosmetique des phaneres, et pour le soin des cheveux, cils ou ongles |
| JP7575722B2 (ja) * | 2019-10-28 | 2024-10-30 | 大正製薬株式会社 | 外用医薬組成物 |
| JP2021123583A (ja) * | 2020-01-31 | 2021-08-30 | 大正製薬株式会社 | 外用医薬製剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2160286A1 (en) * | 1971-11-17 | 1973-06-29 | Metzinger Albert | Lotions contg amniotic fluid - treatment of hair loss |
| NL7414311A (en) * | 1974-11-01 | 1976-05-04 | Drs Teng Hian Khoe | Promoting hair growth with prepn contg urea (deriv) - applied externally, avoiding difficulties of oral medication |
| US4139619A (en) * | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| GB8630721D0 (en) * | 1986-12-23 | 1987-02-04 | Unilever Plc | Cosmetic compositions |
-
1988
- 1988-03-31 LU LU87188A patent/LU87188A1/fr unknown
-
1989
- 1989-03-23 EP EP89400822A patent/EP0336813B1/de not_active Expired - Lifetime
- 1989-03-23 AT AT89400822T patent/ATE81281T1/de not_active IP Right Cessation
- 1989-03-23 DE DE8989400822T patent/DE68903125T2/de not_active Expired - Fee Related
- 1989-03-30 JP JP1076859A patent/JPH01287014A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0336813A2 (de) | 1989-10-11 |
| EP0336813A3 (en) | 1989-10-25 |
| DE68903125D1 (de) | 1992-11-12 |
| ATE81281T1 (de) | 1992-10-15 |
| DE68903125T2 (de) | 1993-03-18 |
| EP0336813B1 (de) | 1992-10-07 |
| JPH01287014A (ja) | 1989-11-17 |
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