LU85312A1 - Diphenylazomethines substituees,leur preparation et leur application en therapeutique - Google Patents
Diphenylazomethines substituees,leur preparation et leur application en therapeutique Download PDFInfo
- Publication number
- LU85312A1 LU85312A1 LU85312A LU85312A LU85312A1 LU 85312 A1 LU85312 A1 LU 85312A1 LU 85312 A LU85312 A LU 85312A LU 85312 A LU85312 A LU 85312A LU 85312 A1 LU85312 A1 LU 85312A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- choh
- chloro
- compound
- preparation
- diphenylazomethines
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 4
- 230000001225 therapeutic effect Effects 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 21
- -1 5-chloro-2-hydroxyphenyl Chemical group 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims description 2
- 239000012965 benzophenone Substances 0.000 claims description 2
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 3
- 229940024874 benzophenone Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 206010028347 Muscle twitching Diseases 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- OSXVZDOVYCTYCW-UHFFFAOYSA-N (5-chloro-2-hydroxyphenyl)-(2-chlorophenyl)methanone Chemical compound OC1=CC=C(Cl)C=C1C(=O)C1=CC=CC=C1Cl OSXVZDOVYCTYCW-UHFFFAOYSA-N 0.000 description 3
- NAXUFNXWXFZVSI-UHFFFAOYSA-N 4-aminobutan-2-ol Chemical compound CC(O)CCN NAXUFNXWXFZVSI-UHFFFAOYSA-N 0.000 description 3
- LDCYZAJDBXYCGN-VIFPVBQESA-N 5-hydroxy-L-tryptophan Chemical compound C1=C(O)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-VIFPVBQESA-N 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
- IYGYMKDQCDOMRE-QRWMCTBCSA-N Bicculine Chemical compound O([C@H]1C2C3=CC=4OCOC=4C=C3CCN2C)C(=O)C2=C1C=CC1=C2OCO1 IYGYMKDQCDOMRE-QRWMCTBCSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- AACMFFIUYXGCOC-UHFFFAOYSA-N bicuculline Natural products CN1CCc2cc3OCOc3cc2C1C4OCc5c6OCOc6ccc45 AACMFFIUYXGCOC-UHFFFAOYSA-N 0.000 description 3
- IYGYMKDQCDOMRE-UHFFFAOYSA-N d-Bicucullin Natural products CN1CCC2=CC=3OCOC=3C=C2C1C1OC(=O)C2=C1C=CC1=C2OCO1 IYGYMKDQCDOMRE-UHFFFAOYSA-N 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 231100000111 LD50 Toxicity 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000001961 anticonvulsive agent Substances 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 229940005513 antidepressants Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 208000020401 Depressive disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000008238 Muscle Spasticity Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 230000000949 anxiolytic effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- SKCNIGRBPJIUBQ-UHFFFAOYSA-N chloroform;ethyl acetate Chemical compound ClC(Cl)Cl.CCOC(C)=O SKCNIGRBPJIUBQ-UHFFFAOYSA-N 0.000 description 1
- 230000002920 convulsive effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 230000003371 gabaergic effect Effects 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 229960002888 oxitriptan Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001242 postsynaptic effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000018198 spasticity Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8306081A FR2544308B1 (fr) | 1983-04-14 | 1983-04-14 | Ethines substituees, leur preparation et leur application en therapeutique |
| FR8306081 | 1983-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU85312A1 true LU85312A1 (fr) | 1985-11-27 |
Family
ID=9287835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU85312A LU85312A1 (fr) | 1983-04-14 | 1984-04-13 | Diphenylazomethines substituees,leur preparation et leur application en therapeutique |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4564636A (fi) |
| JP (1) | JPS59199664A (fi) |
| AU (1) | AU560988B2 (fi) |
| BE (1) | BE899422A (fi) |
| CA (1) | CA1212957A (fi) |
| CH (1) | CH659649A5 (fi) |
| DE (1) | DE3414050A1 (fi) |
| DK (1) | DK191584A (fi) |
| ES (1) | ES8501737A1 (fi) |
| FI (1) | FI841483A (fi) |
| FR (1) | FR2544308B1 (fi) |
| GB (1) | GB2138422B (fi) |
| GR (1) | GR79888B (fi) |
| HU (1) | HU191556B (fi) |
| IL (1) | IL71539A0 (fi) |
| IT (1) | IT1176041B (fi) |
| LU (1) | LU85312A1 (fi) |
| NL (1) | NL8401190A (fi) |
| NO (1) | NO154696C (fi) |
| NZ (1) | NZ207841A (fi) |
| PT (1) | PT78428B (fi) |
| SE (1) | SE8402081L (fi) |
| ZA (1) | ZA842799B (fi) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5939460A (en) * | 1996-07-08 | 1999-08-17 | Idun Pharmaceuticals, Inc. | Method of inhibiting NADPH oxidase |
| US20030186942A1 (en) * | 2002-01-16 | 2003-10-02 | Crooks Peter A. | Compounds of use in the treatment of epilepsy, seizure, and electroconvulsive disorders |
| US9550827B2 (en) | 2007-10-19 | 2017-01-24 | The Regents Of The University Of California | Methods for ameliorating and preventing central nervous system inflammation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1529564A (en) * | 1974-05-01 | 1978-10-25 | Lawson A | Pharmaceutical compositions |
| FR2319338A1 (fr) * | 1975-08-01 | 1977-02-25 | Synthelabo | Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent |
| JPS5337647A (en) * | 1976-09-14 | 1978-04-06 | Mitsubishi Gas Chem Co Inc | Preparation of imine compounds |
| PT69288A (fr) * | 1978-02-27 | 1979-03-01 | Synthelabo | Procede de preparation de derives benzylideniques |
| FR2475543A1 (fr) * | 1980-02-12 | 1981-08-14 | Synthelabo | Derives benzylideniques, leur preparation et leur application en therapeutique |
| US4361583A (en) * | 1980-08-19 | 1982-11-30 | Synthelabo | Analgesic agent |
-
1983
- 1983-04-14 FR FR8306081A patent/FR2544308B1/fr not_active Expired
-
1984
- 1984-04-13 GR GR74420A patent/GR79888B/el unknown
- 1984-04-13 CH CH1877/84A patent/CH659649A5/fr not_active IP Right Cessation
- 1984-04-13 BE BE0/212764A patent/BE899422A/fr not_active IP Right Cessation
- 1984-04-13 GB GB08409685A patent/GB2138422B/en not_active Expired
- 1984-04-13 LU LU85312A patent/LU85312A1/fr unknown
- 1984-04-13 SE SE8402081A patent/SE8402081L/xx not_active Application Discontinuation
- 1984-04-13 ES ES531586A patent/ES8501737A1/es not_active Expired
- 1984-04-13 ZA ZA842799A patent/ZA842799B/xx unknown
- 1984-04-13 NL NL8401190A patent/NL8401190A/nl not_active Application Discontinuation
- 1984-04-13 IL IL71539A patent/IL71539A0/xx unknown
- 1984-04-13 FI FI841483A patent/FI841483A/fi not_active Application Discontinuation
- 1984-04-13 JP JP59075678A patent/JPS59199664A/ja active Pending
- 1984-04-13 PT PT78428A patent/PT78428B/pt not_active IP Right Cessation
- 1984-04-13 NZ NZ207841A patent/NZ207841A/en unknown
- 1984-04-13 NO NO841485A patent/NO154696C/no unknown
- 1984-04-13 CA CA000452021A patent/CA1212957A/en not_active Expired
- 1984-04-13 US US06/599,799 patent/US4564636A/en not_active Expired - Fee Related
- 1984-04-13 HU HU841455A patent/HU191556B/hu not_active IP Right Cessation
- 1984-04-13 IT IT20527/84A patent/IT1176041B/it active
- 1984-04-13 AU AU26822/84A patent/AU560988B2/en not_active Ceased
- 1984-04-13 DK DK191584A patent/DK191584A/da not_active Application Discontinuation
- 1984-04-13 DE DE19843414050 patent/DE3414050A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PT78428B (fr) | 1986-08-22 |
| ES531586A0 (es) | 1984-12-01 |
| PT78428A (fr) | 1984-05-01 |
| NO154696B (no) | 1986-08-25 |
| GR79888B (fi) | 1984-10-31 |
| DK191584A (da) | 1984-10-15 |
| FI841483A (fi) | 1984-10-15 |
| FR2544308B1 (fr) | 1985-06-14 |
| SE8402081D0 (sv) | 1984-04-13 |
| IL71539A0 (en) | 1984-07-31 |
| CA1212957A (en) | 1986-10-21 |
| GB2138422A (en) | 1984-10-24 |
| AU560988B2 (en) | 1987-04-30 |
| HUT34154A (en) | 1985-02-28 |
| AU2682284A (en) | 1984-10-18 |
| FR2544308A1 (fr) | 1984-10-19 |
| NL8401190A (nl) | 1984-11-01 |
| NO154696C (no) | 1986-12-03 |
| NZ207841A (en) | 1986-04-11 |
| JPS59199664A (ja) | 1984-11-12 |
| IT8420527A0 (it) | 1984-04-13 |
| DK191584D0 (da) | 1984-04-13 |
| FI841483A0 (fi) | 1984-04-13 |
| NO841485L (no) | 1984-10-15 |
| CH659649A5 (fr) | 1987-02-13 |
| SE8402081L (sv) | 1984-10-15 |
| DE3414050A1 (de) | 1984-10-18 |
| HU191556B (en) | 1987-03-30 |
| ZA842799B (en) | 1984-11-28 |
| US4564636A (en) | 1986-01-14 |
| ES8501737A1 (es) | 1984-12-01 |
| IT1176041B (it) | 1987-08-12 |
| BE899422A (fr) | 1984-10-15 |
| GB2138422B (en) | 1986-07-16 |
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