LU504846B1 - Golden spherical membrane protein factor for regulating immune function of human body - Google Patents
Golden spherical membrane protein factor for regulating immune function of human body Download PDFInfo
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- LU504846B1 LU504846B1 LU504846A LU504846A LU504846B1 LU 504846 B1 LU504846 B1 LU 504846B1 LU 504846 A LU504846 A LU 504846A LU 504846 A LU504846 A LU 504846A LU 504846 B1 LU504846 B1 LU 504846B1
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Abstract
The present invention is applicable to the technical field of health food, and provides a golden spherical membrane protein factor for regulating immune function of human body, which comprises: 30-56 parts of deep-sea cod peptide, 10-20 parts of special whey spherical membrane, and 10-44 parts of bovine thymosin; wherein, the special whey spherical membrane is obtained by adding 15-25% volume of absolute ethanol to milk, stirring evenly, and then filtering after standing for 30-60 min, adding the absolute ethanol to the obtained filtrate to make the absolute ethanol content reach 35% volume, continuously adding the absolute ethanol until the content gradually reaches 55% volume, stirring evenly, standing for 30-60min, centrifuging at 3000-5000 rpm, and pouring out the supernatant.
Description
DESCRIPTION LU504846
GOLDEN SPHERICAL MEMBRANE PROTEIN FACTOR FOR REGULATING IMMUNE
FUNCTION OF HUMAN BODY
The present invention relates to the technical field of health food, and in particular to a golden spherical membrane protein factor for regulating immune function of human body.
With the acceleration of the pace of life in the global society and the increase of work and psychological pressure, sub-health problems have gradually become the focus of attention.
Sub-health means that the human body is in a state between health and disease. Sub-health state is characterized by decreased vitality, function and adaptability for a period of time, but it does not meet the clinical or subclinical diagnostic criteria of diseases in modern medicine, among which decreased immune function is one of the most common manifestations of sub-health state. Immune system is an important part of the body to resist external pathogenic factors, including specific immunity and non-specific immunity. Under the same conditions, there are differences in resistance among individuals, and individuals with poor resistance are easily affected by pathogenic factors and get sick. Age, constitution and living habits are the main factors that affect the body's immunity. In addition, malnutrition, obesity, underweight and unbalanced dietary intake also significantly affects the function of human immune system.
Therefore, the individual's nutritional status is considered as an important index to evaluate the body's immunity, and good dietary nutrition intake is a key step to promote the body's immunity. At present, research shows that immunoglobulin and lactoferrin are ideal raw materials for immune-enhancing peptides. These raw materials have a variety of biological activities, including broad-spectrum antibacterial effects, enhancing the body's anti-virus, anti-oxidation and immune capabilities, comprehensively preventing and treating infectious diseases, maintaining the balance of gastrointestinal flora, and promoting the transfer and absorption of iron. In view of this sub-health symptom, many health-care and nutritious foods have appeared in the market one after another. Although most of the product formulas até/504846 based on immune-enhancing peptide raw materials such as immunoglobulin and lactoferrin, they still can't effectively improve sub-health symptoms because of the unscientific types and contents of ingredients in the formulas.
Embodiments of the present invention provide a golden spherical membrane protein factor for regulating immune function of human body, which aims to solve a problem that the existing health-care nutritious food cannot effectively improve sub-health symptoms due to unscientific formula component types and contents. The embodiment of the invention is realized as follows, a golden spherical membrane protein factor for regulating immune function of human body, comprises raw materials of the following parts by weight: 30-56 parts of deep-sea cod peptide, 10-20 parts of special whey spherical membrane, and 10-44 parts of bovine thymosin; wherein, a preparation method of the special whey spherical membrane is as follows: adding 15-25% volume of absolute ethanol to milk, stirring evenly, and then filtering after standing for 30-60min, adding the absolute ethanol to the obtained filtrate to make the absolute ethanol content reach 35% volume, continuously adding the absolute ethanol until the content gradually reaches 55% volume, stirring evenly, standing for 30-60min, centrifuging at 3000-5000 rpm, and pouring out the supernatant, and obtaining the special whey spherical membrane.
In an embodiment of the present application, the golden spherical membrane protein factor is prepared by deep-sea cod peptide, special whey spherical membrane and bovine thymosin according to a specific ratio, wherein the core component, special whey spherical membrane is prepared by adding 15-25% volume of absolute ethanol to milk, stirring evenly, and then filtering after standing for 30-60min, adding the absolute ethanol to the obtained filtrate to make the absolute ethanol content reach 35% volume, continuously adding the absolute ethanol until the content gradually reaches 55% volume, stirring evenly, standing for 30-60min, centrifuging at 3000-5000 rpm, and pouring out the supernatant. By adding the special deep-sea cod peptide and the bovine thymosin in proportion, the present applicatid 504846 has a scientific and reasonable formula, high nutritional value, a good curative effect on sub-health conditioning, is safe for using, and has no toxic and side effects on the body, which has positive effects on immune prevention, gastrointestinal tract health and exercise ability improvement of middle-aged and elderly people.
Hereinafter, in order to make the purpose, technical solutions and advantages of the present invention more clearly, the present invention will be further described in detail with specific embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, and are not used to limit the present invention.
The embodiments of the present application provide a golden spherical membrane protein factor for regulating immune function of human body, comprises raw material of the following parts by weight: 30-56 parts of deep-sea cod peptide, 10-20 parts of special whey spherical membrane, and 10-44 parts of bovine thymosin; wherein, a preparation method of the special whey spherical membrane is as follows: adding 15-25% volume of absolute ethanol to milk, stirring evenly, and then filtering after standing for 30-60min, adding the absolute ethanol to the obtained filtrate to make the absolute ethanol content reach 35% volume, continuously adding the absolute ethanol until the content gradually reaches 55% volume, stirring evenly, standing for 30-60min, centrifuging at 3000-5000 rpm, and pouring out the supernatant, and obtaining the special whey spherical membrane.
Optionally, selecting fresh milk from pasture; adding 15-25% anhydrous ethanol into milk, stirring evenly, and then filtering after standing for 30-60min, adding the absolute ethanol to the obtained filtrate to make the absolute ethanol content reach 35%, continuously adding the absolute ethanol until the content gradually reaches 55%, stirring evenly, standing for 30-60min, centrifuging at 3000-5000 rpm, and pouring out the supernatant, and vacuum drying or freeze drying the obtained precipitate, grinding it to 140-180 mesh with a universal pulverizer, and making into capsules or tablets; and removing residual products, packing and storing tHé/504846 qualified ones.
Wherein, the deep-sea cod peptide is obtained by soaking deep-sea cod skin in an alkaline solution, an aqueous solution, an acidic solution, and an aqueous solution, followed by colloid grinding, enzymatic hydrolysis by heating, high temperature and high pressure, and freeze-drying.
Preferably, a preparation method of the deep-sea cod peptide is: sequentially placing the deep-sea cod skin in alkaline solution, aqueous solution, acidic solution, and aqueous solution for soaking treatment; grinding the deep-sea cod skin soaked in the aqueous solution with a colloid mill to obtain a crude collagen solution; placing the crude collagen solution at a temperature of 85-95°C with the enzymolysis liquid for stirring, heating and enzymolysis treating, and then standing for precipitation after stirring to obtain a collagen peptide solution; placing the collagen peptide solution at a temperature of 140-150°C and a pressure of 0.4-0.5mpa for high-temperature and high-pressure treatment; and freezing the collagen peptide solution after high-temperature and high-pressure treatment at -30°C for not less than 6 hours.
Optionally, selecting high-quality deep-sea cod in high-quality sea areas and cooperate with two sets of driving devices to place the deep-sea cod skin in the alkaline pool, pool, acid pool, and pool in turn; grinding: washing the deep-sea cod skin from the pool with clean water into the colloid mill and grinding into a crude collagen solution; heating and enzymatic hydrolysis: transporting the crude collagen solution to the upper reaction furnace and mixing with the enzymatic solution at 85-95°C, and after stirring, the collagen peptide solution is obtained by static precipitation; filtrating: filtering the collagen peptide solution into the lower reaction furnace; high-temperature and high-pressure treatment: the temperature in the lower reaction furnace is 140-150°C, and the pressure is 0.4-0.5mpa for high-temperature and high-pressure treatment; freeze-drying: the collagen peptide solution after high-temperature and high-pressure treatment is frozen below -30°C for more than 6 hours; the soaking time in the alkaline pool, the soaking time in the acidic pool, the grinding time of the colloid mill, tH&)504846 reaction time of the upper reaction furnace and the lower reaction furnace are all the same, which can be 30-80min, namely the deep sea cod peptide.
Wherein, the bovine thymosin is obtained by acid washing and aqueous treatment of bovine thymus, followed by cooking, slag removal, hydrolysis, concentration and spray drying.
Preferably, a preparation method of the bovine thymosin is as follows: sequentially pickling the bovine thymus with acetic acid solution and washing the bovine thymus with the water solution; adding water into a cooking tank, heating up while stirring, adding the washed bovine thymus and edible acetic acid at the same time, raising the temperature to 55°C in a lower part of the cooking pot and 65°C in an upper part thereof, keeping it warm for 60min, stopping stirring, letting stand for 0.5-1.5h, and supernatant is primary solution; immediately after standing still, pumping the primary solution into a sterilized primary solution storage tank with a vacuum extraction tank, wherein temperature of the solution is 50-60°C; pumping the primary solution into a sterilized hydrolysis tank, heating to 100°C for 15min for sterilization, cooling to 55-65°C and maintaining, adding alkali liquor to adjust pH value to neutral, adding enzyme preparation for hydrolysis for 7-9h, and then heating to 90°C for 15min for inactivation; adding diatomaceous earth and activated carbon, stirring, standing, and coarse filtering, circularly filtering for 0.5-1.5h by a plate-and-frame filter to obtain clear liquid; concentrating the clear solution to a concentration of 18-22 °Bonby a vacuum concentrator to obtain a concentrated solution; and
When the concentrate is clear, it is spray-dried to obtain the bovine thymosin.
Optionally, pickling the bovine thymus with acetic acid solution for 0.5-1.5h; then washing once with water, then pickling once with the acetic acid solution for 0.5-1.5h, and washing once with water to obtain the washed bovine thymus; cooking: adding water into a cooking tank, heating up while stirring, adding the washed bovine thymus and edible acetic acid at the same time, raising the temperature to 55°C in a lower part of the cooking pot and 65°C in an upper part thereof, keeping it warm for 60min, stopping stirring, letting stand for 0.5-1.5h, arld/504846 supernatant is primary solution; deslagging: immediately after standing still, pumping the primary solution into a sterilized primary solution storage tank with a vacuum extraction tank, wherein temperature of the solution is 55°C; hydrolysis: pumping the primary solution into a sterilized hydrolysis tank, heating to 100°C for 15min for sterilization, cooling to 55-65°C and maintaining, adding alkali liquor to adjust pH value to neutral, adding enzyme preparation for hydrolysis for 7-9h, and then heating to 90°C for 15min for inactivation; filtrating: adding diatomaceous earth and activated carbon with a mass ratio of 1:1 according to the mass ratio of 0.1%-0.2%, after stirring, standing, and coarse filtering, circularly filtering for 0.5-1.5h by a plate-and-frame filter to obtain clear liquid; concentration: concentrating the clear solution to a concentration of 18-22 °Bé by a vacuum concentrator to obtain a concentrated solution; and spray drying: when the concentrate is clear, it is spray-dried to obtain the bovine thymosin.
In another embodiment of the present application, the golden spherical membrane protein factor for regulating immune function of human body comprises raw material of the following parts by weight: 45-55 parts of the deep-sea cod peptide, 10-20 parts of the special whey spherical membrane, and 30-40 parts of the bovine thymosin.
More preferably, the golden spherical membrane protein factor for regulating immune function of human body comprises raw material of the following parts by weight: parts of the deep-sea cod peptide, 15 parts of the special whey spherical membrane, and 35 parts of the bovine thymosin.
It is worth noting that the embodiments of the present application supplement the special whey spherical membrane with the special deep-sea cod peptide and bovine thymosin in proportion. After a lot of innovative research, the formula obtained is scientific and reasonable.
Adjustment of any component or content ratio will directly affect its conditioning effect on the sub-health state. In addition, the present invention is a special dietary preparation, and the active ingredients of the preparation are all polypeptides and special whey spherical membranes. Through scientific and rational configuration, the preparation of the present invention is a special formula for restoring human breast milk, which has a function #504846 regulating immune function of human body and ensures that the human body can absorb immune factors and growth factors.
Further, a preparation method of the golden spherical membrane protein factor for regulating immune function of human body is that the obtained deep-sea cod peptide, special whey spherical membrane and bovine thymosin are evenly mixed to obtain loose powder, and the loose powder is prepared into tablets, hard capsules or soft capsules according to conventional preparation technology of traditional Chinese medicines.
The present invention is a health care product preparation, effective components of the preparation are all protein, and compatibility of the components is reasonable, and effects of each protein are as follows:
Deep-sea cod collagen peptide has small molecular weight and is easy to be absorbed.
Molecular weight of deep-sea cod collagen peptide is less than 1000Da, so it has good permeability, can be absorbed by the skin, fills in the skin matrix, stretches skin wrinkles, makes it elastic, moisturizes the skin, and delays aging. Moisturizing and moisturizing the skin Cod collagen peptides can effectively improve skin moisture. Deep-sea cod collagen peptides are rich in "macromolecular collagen” and "hydrophilic groups”, which can effectively promote the activity of collagen fiber cells, promote the synthesis of fresh collagen in the dermis of the skin, reduce the formation of melanin, remove freckles and whiten, and delay aging. Cod collagen peptide has obvious advantages both in molecular structure and physiological function, and it is the best choice for supplementing collagen and beauty.
The special whey spherical membrane is rich in a branched-chain amino acid called leucine.
Leucine is the most growth-promoting (anabolic amino acid). For this reason, special whey spherical membranes are effective in preventing age-related muscle loss and improving strength.
For muscle growth, special whey spherical membranes may be slightly better than other types of protein, such as casein or soy. Special whey spherical membranes might lower blood pressure in people with elevated blood pressure. It is due to a bioactive peptide called lactokinin. Much lower amounts of special whey spherical membranes (less than 3.25 g/day) mixed in milk drink$)504846 were not found to have a significant effect on blood pressure. Aids in the treatment of type 2 diabetes, these properties of special whey spherical membranes even rival diabetes medications such as sulfonylureas. Therefore, special whey spherical membranes can be effectively used as a complementary treatment for type 2 diabetes. Special whey spherical membranes are effective in regulating blood sugar levels, especially when taken before or with high carbohydrate meals. It may be especially useful for people with type 2 diabetes. Fights inflammation, which is part of the body's response to injury. Short-term inflammation can be beneficial, but in some cases it can become chronic. Chronic inflammation can be harmful and is a risk factor for many diseases. It may reflect an underlying medical condition or lifestyle habits that are damaging your health. High doses of special whey spherical membranes can reduce blood levels of C-reactive protein, suggesting that it can help reduce inflammation, such as in inflammatory bowel disease.
Bovine thymosin is a natural bioactive peptide with various physiological effects. An immunomodulatory effect: it can enhance the body's immunity, promote cellular immunity and humoral immunity, and inhibit inflammation. A function of growth and development: it can promote growth and development of children and increase their weight. An anti-fatigue effect: it can relieve fatigue, improve the body's endurance and disease resistance. A neuroprotective effect: it can protect nerve cells and improve the symptoms of nervous system diseases.
Hereinafter, examples of certain embodiments of the present application are given, which are not intended to limit the scope of the present application.
In addition, it should be noted that numerical values given in the following embodiments are as accurate as possible, but those skilled in the art understand that due to unavoidable measurement errors and experimental operation problems, each number should be understood as an approximation, rather than an absolutely accurate numerical value.
Embodiment 1
In the present embodiment, a golden spherical membrane protein factor for regulating immune function of human body comprises the following raw material in weight percentage: LU504846 53% of the deep sea cod peptide, 12% of the special whey spherical membrane, 35% of the bovine thymosin.
According to the formula of the above-mentioned a golden spherical membrane protein factor for regulating immune function of human body, the raw material is weighed for later use;
The deep sea cod peptide: selecting high-quality deep-sea cod in high-quality sea areas and cooperate with two sets of driving devices to place the deep-sea cod skin in an alkaline pool, a pool, an acid pool, and a pool in turn; grinding: washing the deep-sea cod skin from the pool with clean water into the colloid mill and grinding into a crude collagen solution; heating and enzymatic hydrolysis: transporting the crude collagen solution to the upper reaction furnace and mixing with the enzymatic solution at 90°C, and after stirring, the collagen peptide solution is obtained by static precipitation; filtrating: filtering the collagen peptide solution into the lower reaction furnace; high-temperature and high-pressure treatment: the temperature in the lower reaction furnace is 145°C, and the pressure is 0.4mpa for high-temperature and high-pressure treatment; freeze-drying: the collagen peptide solution after high-temperature and high-pressure treatment is frozen below -30°C for more than 6 hours; the soaking time in the alkaline pool, the soaking time in the acidic pool, the grinding time of the colloid mill, the reaction time of the upper reaction furnace and the lower reaction furnace is 50min.
The special whey spherical membrane: selecting fresh milk from pasture; adding 20% anhydrous ethanol into milk, stirring evenly, and then filtering after standing for 45min, adding the absolute ethanol to the obtained filtrate to make the absolute ethanol content reach 35%, continuously adding the absolute ethanol until the content gradually reaches 55%, stirring evenly, standing for 45min, centrifuging at 4000 rpm, and pouring out the supernatant, and vacuum drying or freeze drying the obtained precipitate, grinding it to 160 mesh with a universal pulverizer, and making into capsules or tablets; and removing residual products, packing and storing the qualified ones.
The bovine thymosin: pickling the bovine thymus with acetic acid solution for 1h; then washing once with water, then pickling once with the acetic acid solution for 1h, and washihg/504846 once with water to obtain the washed bovine thymus; cooking: adding water into a cooking tank, heating up while stirring, adding the washed bovine thymus and edible acetic acid at the same time, raising the temperature to 55°C in a lower part of the cooking pot and 65°C in an upper part thereof, keeping it warm for 60min, stopping stirring, letting stand for 1h, and supernatant is primary solution; deslagging: immediately after standing still, pumping the primary solution into a sterilized primary solution storage tank with a vacuum extraction tank, wherein temperature of the solution is 55°C; hydrolysis: pumping the primary solution into a sterilized hydrolysis tank, heating to 100°C for 15min for sterilization, cooling to 60°C and maintaining, adding alkali liquor to adjust pH value to neutral, adding enzyme preparation for hydrolysis for 8h, and then heating to 90°C for 15min for inactivation; filtrating: adding diatomaceous earth and activated carbon with a mass ratio of 1:1 according to the mass ratio of 0.2%, after stirring, standing, and coarse filtering, circularly filtering for 1h by a plate-and-frame filter to obtain clear liquid; concentration: concentrating the clear solution to a concentration of °Bé by a vacuum concentrator to obtain a concentrated solution; and spray drying: when the concentrate is clear, it is spray-dried to obtain the bovine thymosin.
The deep-sea cod peptide, the special whey spherical membrane, and the bovine thymosin peptide are evenly mixed to obtain loose powder, and the packaging is checked to obtain the golden spherical membrane protein factor product.
Embodiment 2
In the present embodiment, a golden spherical membrane protein factor for regulating immune function of human body comprises the following raw material in weight percentage: 50% of the deep sea cod peptide, 15% of the special whey spherical membrane, 35% of the bovine thymosin.
According to the formula of the above-mentioned a golden spherical membrane protein factor for regulating immune function of human body, the raw material is weighed for later use;
The deep sea cod peptide: selecting high-quality deep-sea cod in high-quality sea areas and cooperate with two sets of driving devices to place the deep-sea cod skin in an alkaline pool,l&/504846 pool, an acid pool, and a pool in turn; grinding: washing the deep-sea cod skin from the pool with clean water into the colloid mill and grinding into a crude collagen solution; heating and enzymatic hydrolysis: transporting the crude collagen solution to the upper reaction furnace and mixing with the enzymatic solution at 90°C, and after stirring, the collagen peptide solution is obtained by static precipitation; filtrating: filtering the collagen peptide solution into the lower reaction furnace; high-temperature and high-pressure treatment: the temperature in the lower reaction furnace is 145°C, and the pressure is 0.4mpa for high-temperature and high-pressure treatment; freeze-drying: the collagen peptide solution after high-temperature and high-pressure treatment is frozen below -30°C for more than 6 hours; the soaking time in the alkaline pool, the soaking time in the acidic pool, the grinding time of the colloid mill, the reaction time of the upper reaction furnace and the lower reaction furnace is 50min.
The special whey spherical membrane: selecting fresh milk from pasture; adding 20% anhydrous ethanol into milk, stirring evenly, and then filtering after standing for 45min, adding the absolute ethanol to the obtained filtrate to make the absolute ethanol content reach 35%, continuously adding the absolute ethanol until the content gradually reaches 55%, stirring evenly, standing for 45min, centrifuging at 4000 rpm, and pouring out the supernatant, and vacuum drying or freeze drying the obtained precipitate, grinding it to 160 mesh with a universal pulverizer, and making into capsules or tablets; and removing residual products, packing and storing the qualified ones.
The bovine thymosin: pickling the bovine thymus with acetic acid solution for 1h; then washing once with water, then pickling once with the acetic acid solution for 1h, and washing once with water to obtain the washed bovine thymus; cooking: adding water into a cooking tank, heating up while stirring, adding the washed bovine thymus and edible acetic acid at the same time, raising the temperature to 55°C in a lower part of the cooking pot and 65°C in an upper part thereof, keeping it warm for 60min, stopping stirring, letting stand for 1h, and supernatant is primary solution; deslagging: immediately after standing still, pumping the primary solution into a sterilized primary solution storage tank with a vacuum extraction tank,
wherein temperature of the solution is 55°C; hydrolysis: pumping the primary solution intoldJ504846 sterilized hydrolysis tank, heating to 100°C for 15min for sterilization, cooling to 60°C and maintaining, adding alkali liquor to adjust pH value to neutral, adding enzyme preparation for hydrolysis for 8h, and then heating to 90°C for 15min for inactivation; filtrating: adding diatomaceous earth and activated carbon with a mass ratio of 1:1 according to the mass ratio of 0.2%, after stirring, standing, and coarse filtering, circularly filtering for 1h by a plate-and-frame filter to obtain clear liquid; concentration: concentrating the clear solution to a concentration of °Bé by a vacuum concentrator to obtain a concentrated solution; and spray drying: when the concentrate is clear, it is spray-dried to obtain the bovine thymosin.
The deep-sea cod peptide, the special whey spherical membrane, and the bovine thymosin peptide are evenly mixed to obtain loose powder, and the packaging is checked to obtain the golden spherical membrane protein factor product.
Embodiment 3
In the present embodiment, a golden spherical membrane protein factor for regulating immune function of human body comprises the following raw material in weight percentage: 56% of the deep sea cod peptide, 11% of the special whey spherical membrane, 33% of the bovine thymosin.
According to the formula of the above-mentioned a golden spherical membrane protein factor for regulating immune function of human body, the raw material is weighed for later use;
The deep sea cod peptide: selecting high-quality deep-sea cod in high-quality sea areas and cooperating with two sets of driving devices to place the deep-sea cod skin in an alkaline pool, a pool, an acid pool, and a pool in turn; grinding: washing the deep-sea cod skin from the pool with clean water into the colloid mill and grinding into a crude collagen solution; heating and enzymatic hydrolysis: transporting the crude collagen solution to the upper reaction furnace and mixing with the enzymatic solution at 90°C, and after stirring, the collagen peptide solution is obtained by static precipitation; filtrating: filtering the collagen peptide solution into the lower reaction furnace; high-temperature and high-pressure treatment: the temperature in the lower reaction furnace is 145°C, and the pressure is 0.4mpa for high-temperature and high-pressure treatment; freeze-drying: the collagen peptide solution after high-temperatuté/504846 and high-pressure treatment is frozen below -30°C for more than 6 hours; the soaking time in the alkaline pool, the soaking time in the acidic pool, the grinding time of the colloid mill, the reaction time of the upper reaction furnace and the lower reaction furnace is 50min.
The special whey spherical membrane: selecting fresh milk from pasture; adding 20% anhydrous ethanol into milk, stirring evenly, and then filtering after standing for 45min, adding the absolute ethanol to the obtained filtrate to make the absolute ethanol content reach 35%, continuously adding the absolute ethanol until the content gradually reaches 55%, stirring evenly, standing for 45min, centrifuging at 4000 rpm, and pouring out the supernatant, and vacuum drying or freeze drying the obtained precipitate, grinding it to 160 mesh with a universal pulverizer, and making into capsules or tablets; and removing residual products, packing and storing the qualified ones.
The bovine thymosin: pickling the bovine thymus with acetic acid solution for 1h; then washing once with water, then pickling once with the acetic acid solution for 1h, and washing once with water to obtain the washed bovine thymus; cooking: adding water into a cooking tank, heating up while stirring, adding the washed bovine thymus and edible acetic acid at the same time, raising the temperature to 55°C in a lower part of the cooking pot and 65°C in an upper part thereof, keeping it warm for 60min, stopping stirring, letting stand for 1h, and supernatant is primary solution; deslagging: immediately after standing still, pumping the primary solution into a sterilized primary solution storage tank with a vacuum extraction tank, wherein temperature of the liquid is 55°C; hydrolysis: pumping the primary solution into a sterilized hydrolysis tank, heating to 100°C for 15min for sterilization, cooling to 60°C and maintaining, adding alkali liquor to adjust pH value to neutral, adding enzyme preparation for hydrolysis for 8h, and then heating to 90°C for 15min for inactivation; filtrating: adding diatomaceous earth and activated carbon with a mass ratio of 1:1 according to the mass ratio of 0.2%, after stirring, standing, and coarse filtering, circularly filtering for 1h by a plate-and-frame filter to obtain clear liquid; concentration: concentrating the clear solution to a concentration of °Bé by a vacuum concentrator to obtain a concentrated solution; and spray drying: when the concentrate is clear, it is spray-dried to obtain the bovine thymosin. LU504846
The deep-sea cod peptide, the special whey spherical membrane, and the bovine thymosin peptide are evenly mixed to obtain loose powder, and the packaging is checked to obtain the golden spherical membrane protein factor product.
Embodiment 4
In the present embodiment, a golden spherical membrane protein factor for regulating immune function of human body comprises the following raw material in weight percentage: 46% of the deep sea cod peptide, 10% of the special whey spherical membrane, 44% of the bovine thymosin.
According to the formula of the above-mentioned a golden spherical membrane protein factor for regulating immune function of human body, the raw material is weighed for later use;
The deep sea cod peptide: selecting high-quality deep-sea cod in high-quality sea areas and cooperate with two sets of driving devices to place the deep-sea cod skin in an alkaline pool, a pool, an acid pool, and a pool in turn; grinding: washing the deep-sea cod skin from the pool with clean water into the colloid mill and grinding into a crude collagen solution; heating and enzymatic hydrolysis: transporting the crude collagen solution to the upper reaction furnace and mixing with the enzymatic solution at 90°C, and after stirring, the collagen peptide solution is obtained by static precipitation; filtrating: filtering the collagen peptide solution into the lower reaction furnace; high-temperature and high-pressure treatment: the temperature in the lower reaction furnace is 145°C, and the pressure is 0.4mpa for high-temperature and high-pressure treatment; freeze-drying: the collagen peptide solution after high-temperature and high-pressure treatment is frozen below -30°C for more than 6 hours; the soaking time in the alkaline pool, the soaking time in the acidic pool, the grinding time of the colloid mill, the reaction time of the upper reaction furnace and the lower reaction furnace is 50min.
The special whey spherical membrane: selecting fresh milk from pasture; adding 20% anhydrous ethanol into milk, stirring evenly, and then filtering after standing for 45min, adding the absolute ethanol to the obtained filtrate to make the absolute ethanol content reach 35%/504846 continuously adding the absolute ethanol until the content gradually reaches 55%, stirring evenly, standing for 45min, centrifuging at 4000 rpm, and pouring out the supernatant, and vacuum drying or freeze drying the obtained precipitate, grinding it to 160 mesh with a universal pulverizer, and making into capsules or tablets; and removing residual products, packing and storing the qualified ones.
The bovine thymosin: pickling the bovine thymus with acetic acid solution for 1h; then washing once with water, then pickling once with the acetic acid solution for 1h, and washing once with water to obtain the washed bovine thymus; cooking: adding water into a cooking tank, heating up while stirring, adding the washed bovine thymus and edible acetic acid at the same time, raising the temperature to 55°C in a lower part of the cooking pot and 65°C in an upper part thereof, keeping it warm for 60min, stopping stirring, letting stand for 1h, and supernatant is primary solution; deslagging: immediately after standing still, pumping the primary solution into a sterilized primary solution storage tank with a vacuum extraction tank, wherein temperature of the solution is 55°C; hydrolysis: pumping the primary solution into a sterilized hydrolysis tank, heating to 100°C for 15min for sterilization, cooling to 60°C and maintaining, adding alkali liquor to adjust pH value to neutral, adding enzyme preparation for hydrolysis for 8h, and then heating to 90°C for 15min for inactivation; filtrating: adding diatomaceous earth and activated carbon with a mass ratio of 1:1 according to the mass ratio of 0.2%, after stirring, standing, and coarse filtering, circularly filtering for 1h by a plate-and-frame filter to obtain clear liquid; concentration: concentrating the clear solution to a concentration of °Bé by a vacuum concentrator to obtain a concentrated solution; and spray drying: when the concentrate is clear, it is spray-dried to obtain the bovine thymosin.
The deep-sea cod peptide, the special whey spherical membrane, and the bovine thymosin peptide are evenly mixed to obtain loose powder, and the packaging is checked to obtain the golden spherical membrane protein factor product.
The golden spherical membrane protein factor products prepared in Embodiments 1-4 are tested for quality, and test results are shown in Table 1 below: LU504846
Table 1
CN a
Weight difference (%) up to up to up to up to specification specification specification specification
Microbial Limit up to up to up to up to specification specification specification specification
The golden spherical membrane protein factor prepared in embodiment 2 is tested clinically, specifically as follows:
Clinical data: a randomized double-blind controlled trial for middle-aged and elderly people was carried out during the Japanese influenza epidemic. The study included 85 middle-aged and elderly people aged 48 to 80, and they were randomly divided into two groups as per the blinded experiment method. The intervention group took the golden spherical membrane immune protein factor every day, and the control group took ordinary peptide powder every day. The substances in the two groups were indistinguishable from the senses. After a period of time, the influence of factors such as the frequency of occurrence of symptoms of influenza infection in users after product intervention was evaluated. This application mainly evaluates the incidence of influenza symptoms among the participants during the trial period, and the relevant symptoms are obtained by recording daily body temperature and influenza-like symptoms in the volunteers' logbook. Table 2 shows the results of pairwise comparisons of the incidence of influenza symptoms between the intervention and control groups. According to the results, the incidence of influenza symptoms in the golden spherical membrane immune protein group was significantly lower than that in the thymus albumin group, and the difference was statistically significant (P<0.05).
Table 2 Percentage of influenza symptoms in each product group (stratified by age and LU504846 experimental products)
Experimental Golden spherical membrane Thymus albumin
Age P value place immune protein factor (n=39) (n=42) 48~55 1.32+3.01 4.724 6.97 <0.05 55-60 0.00+0.00 3.42+8.71 <0.05
Osaka 60~68 0.00+0.00 2.91+ 4.76 <0.05 68775 0.64+1.96 2.65+4.43 <0.05 75-80 1.00+0.82 3.86 + 5.21 <0.05
Total 0.59+1.16 3.516 + 6.02 <0.05
Meanwhile, the present application explores the impact of interventions on the duration of influenza symptoms. The duration of influenza symptoms was defined as the cumulative number of days from the onset of influenza symptoms (oral body temperature = 38°C, accompanied by at least one influenza-like symptom, such as cough, nasal congestion, sore throat, headache, muscle pain, weakness, dyspnea, retrosternal pain, or loss of appetite) to the disappearance of all symptoms during the trial period. According to the test results, among the volunteers with influenza symptoms, the duration of symptoms of the golden spherical membrane immune protein factor was about 3.322 days lower than that of the thymus albumin as a whole, and the difference was statistically significant (P<0.05). In addition, the duration of influenza symptoms in all age groups in the intervention group was significantly lower than that in the control group. The relevant results are shown in Table 3.
Table 3 Cumulative days of influenza symptoms in each experimental group during experimenktU504846 (all volunteers) mean + standard deviation
Experimental Golden spherical membrane Thymus albumin
Age P value place immune protein factor(n=39) (n=42) 48~55 1.32+3.01 4.724 6.97 <0.05 55-60 0.00+0.00 3.42+8.71 <0.05
Osaka 60~68 0.00+0.00 2.91+ 4.76 <0.05 68775 0.64+1.96 2.65+4.43 <0.05 75-80 1.00+0.82 3.86 + 5.21 <0.05
Total 0.59+1.16 3.516 + 6.02 <0.05
Finally, for test subjects, the present application further records the number of sick leave caused by influenza. During the whole experiment, five people took sick leave caused by influenza, wherein one person took the golden spherical membrane immune protein factor, and four people took thymus albumin. From the data in Table 4, it can be seen that the number of sick leave patients who took the golden spherical membrane immune protein factor was significantly lower than those who took thymus albumin, and the difference was statistically significant (P<0.05).
Table 4 Percentage of sick leave rate (stratified by product taken) caused by influenza in the experimental period group
Golden spherical membrane
Experimental
Age immune protein Thymus albumin P value place factor(n=39) 48755 0.00% 5.16% <0.05 55-60 2.67% 7.12% <0.05
Osaka 60~68 0.00% 5.13% <0.05 68~75 0.00% 6.71% <0.05 75~80 0.00% 2.01% <0.05
Total 2.67% 26.13% <0.05
In addition to the research experiments mentioned above, the present application further conducted a randomized double-blind crossover trial, specifically, 26 men and women who were overweight (BMI: 25-29.9kg/m2) or obese (BMI: 30-39.9kg/m2) were randomly divided into a group receiving the intervention of the golden spherical membrane immune protein factor and a control group not receiving the intervention of the golden spherical membrane immune protein factor. After 1-2 weeks of metabolism after equal caloric food intake, serum cytokines, adhesion factors, cortisol, and inflammatory markers were measured at 0, 1, 3, and 6 hours. Glucose, insulin, and lipid profiles in plasma were also analyzed. The results of the study showed that the area under the curve of total cholesterol, low-density lipoprotein, soluble intracellular adhesion molecules and insulin in the group receiving the intervention of the golden spherical membrane immune protein factor was lower than that in the control group not receiving the intervention, while the level of the anti-inflammatory factor IL-10 was increased.
This suggests that the addition of golden spherical membrane immune protein factor to a high-saturated-fat meal reduces postprandial insulinemia and inflammatory responses in overweight and obese adults. In addition, the trial also conducted related investigations, and the results showed that the intervention group had improvements in physical strength, sleep and skin, which may be attributed to the immune-enhancing and anti-oxidative effects of the golden spherical membrane immune protein factor.
In conclusion, the golden spherical membrane immune protein factor and related components thereof play a positive role in the immune prevention, gastrointestinal health and exercise ability improvement of the middle-aged and elderly. Taking the golden spherical membrane immune protein factor of the present application is a safe and effective dietary nutritional supplement for middle-aged and elderly people.
The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within spirit and principles of the present invention shall fall within the protection scope of the present invention.
Claims (8)
1. A golden spherical membrane protein factor for regulating immune function of human body, comprises raw materials of the following parts by weight: 30-56 parts of deep-sea cod peptide, 10-20 parts of special whey spherical membrane, and 10-44 parts of bovine thymosin; wherein, a preparation method of the special whey spherical membrane is as follows: adding 15-25% volume of absolute ethanol to milk, stirring evenly, and then filtering after standing for 30-60 min, adding the absolute ethanol to the obtained filtrate to make the absolute ethanol content reach 35% volume, continuously adding the absolute ethanol until the content gradually reaches 55% volume, stirring evenly, standing for 30-60 min, centrifuging at 3000-5000 rpm, and pouring out the supernatant, and obtaining the special whey spherical membrane.
2. The golden spherical membrane protein factor for regulating immune function of human body according to claim 1, comprises raw materials of the following parts by weight: 45-55 parts of the deep-sea cod peptide, 10-20 parts of the special whey spherical membrane, and 30-40 parts of the bovine thymosin.
3. The golden spherical membrane protein factor for regulating immune function of human body according to claim 1, comprises raw materials of the following parts by weight: parts of the deep-sea cod peptide, 15 parts of the special whey spherical membrane, and 35 parts of the bovine thymosin.
4. The golden spherical membrane protein factor for regulating immune function of human body according to claim 1, wherein the deep-sea cod peptide is obtained by soaking deep-sea cod skin in an alkaline solution, an aqueous solution, an acidic solution, and an aqueous solution, followed by colloid grinding, enzymatic hydrolysis by heating, high temperature and high pressure, and freeze-drying.
5. The golden spherical membrane protein factor for regulating immune function of human body according to claim 1 or claim 4, wherein a preparation method of the deep-sea cod peptide is: sequentially placing the deep-sea cod skin in alkaline solution, aqueous solution, acidic solution, and aqueous solution for soaking treatment; grinding the deep-sea cod skin soaked in the aqueous solution with a colloid mill to obtain a crude collagen solution; placing the crude collagen solution at a temperature of 85-95°C with the enzymolysis liquid for stirring, heating and enzymolysis treating, and then standing for precipitation after stirring to obtain a collagen peptide solution; placing the collagen peptide solution at a temperature of 140-150°C and a pressure of
0.4-0.5 mpa for high-temperature and high-pressure treatment; and freezing the collagen peptide solution after high-temperature and high-pressure treatment at -30°C for not less than 6 hours.
6. The golden spherical membrane protein factor for regulating immune function of human body according to claim 1, wherein the bovine thymosin is obtained by acid washing and aqueous treatment of bovine thymus, cooking, slag removal, hydrolysis, concentration and spray drying.
7. The golden spherical membrane protein factor for regulating immune function of human body according to claim 1 or claim 6, wherein a preparation method of the bovine thymosin is as follows: sequentially pickling the bovine thymus with acetic acid solution and washing the bovine thymus with the water solution; adding water into a cooking tank, heating up while stirring, adding the washed bovine thymus and edible acetic acid at the same time, raising the temperature to 55°C in a lower part of the cooking pot and 65°C in an upper part thereof, maintaining the temperature for 60 min, stopping stirring, letting stand for 0.5-1.5h, and supernatant is primary solution;
immediately after standing still, pumping the primary solution into a sterilized primak/W504846 solution storage tank with a vacuum extraction tank, wherein temperature of the solution is 50-60°C; pumping the primary solution into a sterilized hydrolysis tank, heating to 100°C for 15min for sterilization, cooling to 55-65°C and maintaining, adding alkali liquor to adjust pH value to neutral, adding enzyme preparation for hydrolysis for 7-9h, and then heating to 90°C for 15min for inactivation; adding diatomaceous earth and activated carbon, after stirring, standing, and coarse filtering, circularly filtering for 0.5-1.5h by a plate-and-frame filter to obtain clear liquid; concentrating the clear solution to a concentration of 18-22 °Bo by a vacuum concentrator to obtain a concentrated solution; and when the concentrate is clear, pray-drying the concentrate to obtain the bovine thymosin.
8. The golden spherical membrane protein factor for regulating immune function of human body according to claim 1, wherein the golden spherical membrane protein factor for regulating immune function of human body is in the form of tablets, hard capsules or soft capsules.
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