LU102470B1 - Epristeride impurity and preparation method and application thereof - Google Patents

Epristeride impurity and preparation method and application thereof Download PDF

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Publication number
LU102470B1
LU102470B1 LU102470A LU102470A LU102470B1 LU 102470 B1 LU102470 B1 LU 102470B1 LU 102470 A LU102470 A LU 102470A LU 102470 A LU102470 A LU 102470A LU 102470 B1 LU102470 B1 LU 102470B1
Authority
LU
Luxembourg
Prior art keywords
epristeride
impurity
preparation
organic solvent
carrying
Prior art date
Application number
LU102470A
Other languages
English (en)
French (fr)
Other versions
LU102470A1 (en
Inventor
Jie Zhao
Qiu He
Kun Huang
Bo Yu
Original Assignee
Jiangsu Lianhuan Pharmaceutical Co Ltd
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Publication date
Application filed by Jiangsu Lianhuan Pharmaceutical Co Ltd filed Critical Jiangsu Lianhuan Pharmaceutical Co Ltd
Publication of LU102470A1 publication Critical patent/LU102470A1/en
Application granted granted Critical
Publication of LU102470B1 publication Critical patent/LU102470B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N2030/067—Preparation by reaction, e.g. derivatising the sample

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  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LU102470A 2020-03-16 2020-12-13 Epristeride impurity and preparation method and application thereof LU102470B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010185261.0A CN111362999B (zh) 2020-03-16 2020-03-16 一种爱普列特杂质及其制备方法和应用

Publications (2)

Publication Number Publication Date
LU102470A1 LU102470A1 (en) 2021-11-09
LU102470B1 true LU102470B1 (en) 2021-12-06

Family

ID=71202553

Family Applications (1)

Application Number Title Priority Date Filing Date
LU102470A LU102470B1 (en) 2020-03-16 2020-12-13 Epristeride impurity and preparation method and application thereof

Country Status (3)

Country Link
CN (1) CN111362999B (zh)
LU (1) LU102470B1 (zh)
WO (1) WO2021184789A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111362999B (zh) * 2020-03-16 2022-03-29 江苏联环药业股份有限公司 一种爱普列特杂质及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
DK0567271T3 (da) * 1992-04-20 1998-02-16 Sankyo Co Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf
GB9224148D0 (en) * 1992-11-18 1993-01-06 Smithkline Beecham Corp Compounds
CA2462456C (en) * 2001-10-03 2010-05-04 Merck & Co., Inc. Androstane 17-beta-carboxamides as androgen receptor modulators
CN102002085B (zh) * 2009-08-28 2012-08-08 江苏联环药业股份有限公司 一种爱普列特的制备方法
EP2594561A1 (en) * 2011-11-18 2013-05-22 Institut Pasteur Structural variants of mycolactones for use in modulating inflammation, immunity and pain
CN108530434A (zh) * 2017-03-03 2018-09-14 重庆医药工业研究院有限责任公司 卡格列净的杂质化合物及其制备方法
CN111362999B (zh) * 2020-03-16 2022-03-29 江苏联环药业股份有限公司 一种爱普列特杂质及其制备方法和应用
CN111624291B (zh) * 2020-06-15 2022-11-25 江苏联环药业股份有限公司 一种利用hplc测定爱普列特片中杂质含量的方法

Also Published As

Publication number Publication date
LU102470A1 (en) 2021-11-09
CN111362999B (zh) 2022-03-29
WO2021184789A1 (zh) 2021-09-23
CN111362999A (zh) 2020-07-03

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Effective date: 20211206