LTIP111A - The use of certain therapeutically imidazoles for manufacture of pharmaceutical preparations to be administered transdermally - Google Patents

The use of certain therapeutically imidazoles for manufacture of pharmaceutical preparations to be administered transdermally

Info

Publication number
LTIP111A
LTIP111A LTIP111A LTIP111A LTIP111A LT IP111 A LTIP111 A LT IP111A LT IP111 A LTIP111 A LT IP111A LT IP111 A LTIP111 A LT IP111A LT IP111 A LTIP111 A LT IP111A
Authority
LT
Lithuania
Prior art keywords
imidazoles
manufacture
pharmaceutical preparations
administered transdermally
certain therapeutically
Prior art date
Application number
LTIP111A
Other languages
Lithuanian (lt)
Inventor
Harry Jalonen
Arvo Sakari Risto Lammintausta
Original Assignee
Orion-Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion-Yhtymae Oy filed Critical Orion-Yhtymae Oy
Publication of LTIP111A publication Critical patent/LTIP111A/en
Publication of LT3005B publication Critical patent/LT3005B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Šis išradimas skirtas perodiniam preparatui, susidedančiam iš terapiškai aktyvaus junginio, apibrėžti formule@@@@@@ (I)@@@@@@@@arba@@@@@@@ (II)@@@@@@@@kurioje R1, R2 ir R3, gali būti vienodi arba skirtingi, yra H, CH3, C2H5 arba Cl; X yra CH=CH arba (CH2)n, kur n yra nuo 1 iki 3 arba X yra -C(OR5)H-, kur R5 yra metilas arba etilas; R4 yra vandenilis arba grynasis alkilas, turintis nuo 1 iki 4 anglies atomų. Perodinis junginių įvedimas gali būti atliekamas preparatais, paruoštais tepalo, emulsijos, pavilgo, tirpalo, kremo, drebučių arba perodinio tvarsčio pavidalo.The present invention relates to a perodic preparation comprising a therapeutically active compound as defined by the formula @@@@@@@@@@@@@@@@@@@@ (@) @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@ wherein R 1, R 2 and R 3 may be the same or different are H, CH 3, C 2 H 5 or Cl; X is CH = CH or (CH 2) n where n is 1 to 3 or X is -C (OR 5) H-, wherein R 5 is methyl or ethyl; R4 is hydrogen or pure alkyl having 1 to 4 carbon atoms. Periodic administration of the compounds may be carried out in the form of preparations prepared in the form of ointments, emulsions, dressings, solutions, creams, jellies or perodic dressings.

LTIP111A 1991-05-31 1992-05-29 USE OF CERTAIN THERAPY ACTIVATED 4-CHANGED IMIDAZOLS FOR PRODUCTION OF PERODIC PHARMACEUTICALS \ t LT3005B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9111773A GB2256135B (en) 1991-05-31 1991-05-31 Transdermal administration of 4-substituted imidazoles

Publications (2)

Publication Number Publication Date
LTIP111A true LTIP111A (en) 1994-03-25
LT3005B LT3005B (en) 1994-08-25

Family

ID=10695905

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP111A LT3005B (en) 1991-05-31 1992-05-29 USE OF CERTAIN THERAPY ACTIVATED 4-CHANGED IMIDAZOLS FOR PRODUCTION OF PERODIC PHARMACEUTICALS \ t

Country Status (18)

Country Link
US (1) US5464628A (en)
EP (1) EP0586467B1 (en)
JP (1) JP3269822B2 (en)
AT (1) ATE199317T1 (en)
AU (1) AU1780892A (en)
CA (1) CA2110162C (en)
DE (1) DE69231709T2 (en)
DK (1) DK0586467T3 (en)
EE (1) EE02994B1 (en)
ES (1) ES2154636T3 (en)
FI (1) FI935350A7 (en)
GB (1) GB2256135B (en)
GR (1) GR3035499T3 (en)
IE (1) IE66188B1 (en)
LT (1) LT3005B (en)
LV (1) LV10042B (en)
NO (1) NO307365B1 (en)
WO (1) WO1992021334A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006788A1 (en) * 1995-08-14 1997-02-27 Janssen Pharmaceutica N.V. Transdermal administration of vorozole
US5891461A (en) * 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
US5807570A (en) * 1995-09-29 1998-09-15 Cygnus, Inc. Transdermal administration of ropinirole and analogs thereof
GB9614098D0 (en) 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
DE19820151A1 (en) * 1998-05-06 1999-11-11 Hexal Ag Transdermal therapeutic system for the application of candesartan
TW200930291A (en) 2002-04-29 2009-07-16 Bayer Cropscience Ag Pesticidal heterocycles
FI20041425A0 (en) * 2004-11-05 2004-11-05 Orion Corp Transmucosal veterinary composition
AU2004325626B2 (en) * 2004-12-15 2010-12-09 Drossapharm Ag External patches containing etofenamate
WO2007085556A2 (en) 2006-01-27 2007-08-02 F. Hoffmann-La Roche Ag Use of 4-imidazole derivatives for cns disorders
EP2053917B1 (en) * 2006-08-08 2010-03-03 Intervet International BV Composition for enhanced antiparasitic activity
US7795263B2 (en) * 2008-07-08 2010-09-14 Wildlife Laboratories, Inc. Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals
US20210323929A1 (en) * 2018-07-18 2021-10-21 Clexio Biosciences Ltd. Purified Detomidine, Process of Preparing and Methods of Use
WO2020222188A1 (en) 2019-05-01 2020-11-05 Clexio Biosciences Ltd. Methods of treating pruritus
CN112220767B (en) * 2020-09-25 2022-10-25 安徽省公众检验研究院有限公司 Preparation method of altimezole hydrochloride sustained-release tablet

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU518569B2 (en) * 1979-08-07 1981-10-08 Farmos-Yhtyma Oy 4-benzyl- and 4-benzoyl imidazole derivatives
GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
GB2167408B (en) 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
US4672344A (en) 1985-04-19 1987-06-09 Siemens Aktiengesellschaft Polarized electromagnetic relay
FI864570A0 (en) 1986-11-11 1986-11-11 Farmos Oy THERAPEUTIC ANVAENDBAR FOERENING.
US5124157A (en) * 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
FI894911A0 (en) * 1989-10-17 1989-10-17 Farmos Oy EN TERAPEUTISKT VAERDEFULL FOERENING.
US5304569A (en) * 1989-11-13 1994-04-19 Orion-Yhtyma Oy Compositions and their use in lowering intraocular pressure

Also Published As

Publication number Publication date
CA2110162C (en) 2002-11-12
ATE199317T1 (en) 2001-03-15
FI935350L (en) 1993-11-30
LV10042A (en) 1994-05-10
DK0586467T3 (en) 2001-03-26
NO307365B1 (en) 2000-03-27
JP3269822B2 (en) 2002-04-02
EE02994B1 (en) 1997-06-16
JPH06507618A (en) 1994-09-01
GB2256135A (en) 1992-12-02
FI935350A0 (en) 1993-11-30
NO934261L (en) 1993-11-25
EP0586467B1 (en) 2001-02-28
GB9111773D0 (en) 1991-07-24
LV10042B (en) 1995-02-20
IE921938A1 (en) 1992-12-02
DE69231709T2 (en) 2001-10-04
US5464628A (en) 1995-11-07
GB2256135B (en) 1995-01-18
DE69231709D1 (en) 2001-04-05
AU1780892A (en) 1993-01-08
WO1992021334A1 (en) 1992-12-10
NO934261D0 (en) 1993-11-25
CA2110162A1 (en) 1992-12-10
GR3035499T3 (en) 2001-06-29
FI935350A7 (en) 1993-11-30
LT3005B (en) 1994-08-25
ES2154636T3 (en) 2001-04-16
IE66188B1 (en) 1995-12-13
EP0586467A1 (en) 1994-03-16

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Effective date: 20060529