ES2154636T3 - PHARMACEUTICAL COMPOSITIONS CONTAINING 4-SUBSTITUTED IMIDAZOLS FOR ADMINISTRATION BY TRANSDERMAL VIA. - Google Patents
PHARMACEUTICAL COMPOSITIONS CONTAINING 4-SUBSTITUTED IMIDAZOLS FOR ADMINISTRATION BY TRANSDERMAL VIA.Info
- Publication number
- ES2154636T3 ES2154636T3 ES92910941T ES92910941T ES2154636T3 ES 2154636 T3 ES2154636 T3 ES 2154636T3 ES 92910941 T ES92910941 T ES 92910941T ES 92910941 T ES92910941 T ES 92910941T ES 2154636 T3 ES2154636 T3 ES 2154636T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- transdermal
- administration
- imidazols
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
PCT No. PCT/FI92/00166 Sec. 371 Date Nov. 12, 1993 Sec. 102(e) Date Nov. 12, 1993 PCT Filed May 27, 1992 PCT Pub. No. WO92/21334 PCT Pub. Date Dec. 10, 1992.This invention relates to a transdermal preparation comprising a therapeutically active compound of the formula: <IMAGE> (I) or <IMAGE> (II) where R1, R2, and R3, which can be the same or different are H, CH3, C2H5 or Cl; X is CH=CH or (CH2)n where n is 1 to 3 or X is -C(OR5)H- where R5 is methyl or ethyl; and R4 is hydrogen or a straight alkyl of 1 to 4 carbon atoms. The transdermal administration of the compounds can be accomplished by preparations in the form of ointments, emulsions, lotions, solutions, creams or transdermal patches.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9111773A GB2256135B (en) | 1991-05-31 | 1991-05-31 | Transdermal administration of 4-substituted imidazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2154636T3 true ES2154636T3 (en) | 2001-04-16 |
Family
ID=10695905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92910941T Expired - Lifetime ES2154636T3 (en) | 1991-05-31 | 1992-05-27 | PHARMACEUTICAL COMPOSITIONS CONTAINING 4-SUBSTITUTED IMIDAZOLS FOR ADMINISTRATION BY TRANSDERMAL VIA. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5464628A (en) |
EP (1) | EP0586467B1 (en) |
JP (1) | JP3269822B2 (en) |
AT (1) | ATE199317T1 (en) |
AU (1) | AU1780892A (en) |
CA (1) | CA2110162C (en) |
DE (1) | DE69231709T2 (en) |
DK (1) | DK0586467T3 (en) |
EE (1) | EE02994B1 (en) |
ES (1) | ES2154636T3 (en) |
FI (1) | FI935350A (en) |
GB (1) | GB2256135B (en) |
GR (1) | GR3035499T3 (en) |
IE (1) | IE66188B1 (en) |
LT (1) | LT3005B (en) |
LV (1) | LV10042B (en) |
NO (1) | NO307365B1 (en) |
WO (1) | WO1992021334A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997006788A1 (en) * | 1995-08-14 | 1997-02-27 | Janssen Pharmaceutica N.V. | Transdermal administration of vorozole |
US5891461A (en) * | 1995-09-14 | 1999-04-06 | Cygnus, Inc. | Transdermal administration of olanzapine |
US5807570A (en) * | 1995-09-29 | 1998-09-15 | Cygnus, Inc. | Transdermal administration of ropinirole and analogs thereof |
GB9614098D0 (en) | 1996-07-05 | 1996-09-04 | Orion Yhtymae Oy | Transdermal delivery of levosimendan |
DE19820151A1 (en) * | 1998-05-06 | 1999-11-11 | Hexal Ag | Transdermal therapeutic system for the application of candesartan |
TW200306783A (en) | 2002-04-29 | 2003-12-01 | Fmc Corp | Pesticidal heterocycles |
FI20041425A0 (en) * | 2004-11-05 | 2004-11-05 | Orion Corp | Transmucosal veterinary composition |
WO2006064576A1 (en) * | 2004-12-15 | 2006-06-22 | Teikoku Seiyaku Co., Ltd. | External patches containing etofenamate |
DE602007004949D1 (en) | 2006-01-27 | 2010-04-08 | Hoffmann La Roche | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISEASES |
ATE459251T1 (en) * | 2006-08-08 | 2010-03-15 | Intervet Int Bv | COMPOSITION FOR ENHANCED ANTIPARASITIC EFFECTIVENESS |
US7795263B2 (en) * | 2008-07-08 | 2010-09-14 | Wildlife Laboratories, Inc. | Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals |
WO2020016827A1 (en) * | 2018-07-18 | 2020-01-23 | Clexio Biosciences Ltd. | Purified crystalline detomidine hydrochloride monohydrate, anhydrate and free base with low amounts of iso-detomidine and other impurities by recrystallisation in water |
MX2021012824A (en) | 2019-05-01 | 2022-10-19 | Clexio Biosciences Ltd | Methods of treating pruritus. |
CN112220767B (en) * | 2020-09-25 | 2022-10-25 | 安徽省公众检验研究院有限公司 | Preparation method of altimezole hydrochloride sustained-release tablet |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU518569B2 (en) * | 1979-08-07 | 1981-10-08 | Farmos-Yhtyma Oy | 4-benzyl- and 4-benzoyl imidazole derivatives |
GB2069481B (en) * | 1980-02-13 | 1983-07-27 | Farmos Oy | Substituted imidazole derivatives |
GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
GB2167408B (en) | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
US4672344A (en) | 1985-04-19 | 1987-06-09 | Siemens Aktiengesellschaft | Polarized electromagnetic relay |
FI864570A0 (en) | 1986-11-11 | 1986-11-11 | Farmos Oy | THERAPEUTIC ANVAENDBAR FOERENING. |
US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
FI894911A0 (en) * | 1989-10-17 | 1989-10-17 | Farmos Oy | EN TERAPEUTISKT VAERDEFULL FOERENING. |
US5304569A (en) * | 1989-11-13 | 1994-04-19 | Orion-Yhtyma Oy | Compositions and their use in lowering intraocular pressure |
-
1991
- 1991-05-31 GB GB9111773A patent/GB2256135B/en not_active Revoked
-
1992
- 1992-05-27 WO PCT/FI1992/000166 patent/WO1992021334A1/en active IP Right Grant
- 1992-05-27 DK DK92910941T patent/DK0586467T3/en active
- 1992-05-27 AU AU17808/92A patent/AU1780892A/en not_active Abandoned
- 1992-05-27 DE DE69231709T patent/DE69231709T2/en not_active Expired - Fee Related
- 1992-05-27 EP EP92910941A patent/EP0586467B1/en not_active Expired - Lifetime
- 1992-05-27 CA CA002110162A patent/CA2110162C/en not_active Expired - Fee Related
- 1992-05-27 JP JP50981692A patent/JP3269822B2/en not_active Expired - Fee Related
- 1992-05-27 ES ES92910941T patent/ES2154636T3/en not_active Expired - Lifetime
- 1992-05-27 US US08/146,203 patent/US5464628A/en not_active Expired - Fee Related
- 1992-05-27 AT AT92910941T patent/ATE199317T1/en not_active IP Right Cessation
- 1992-05-28 LV LVP-92-19A patent/LV10042B/en unknown
- 1992-05-29 LT LTIP111A patent/LT3005B/en not_active IP Right Cessation
- 1992-07-01 IE IE921938A patent/IE66188B1/en not_active IP Right Cessation
-
1993
- 1993-11-25 NO NO934261A patent/NO307365B1/en unknown
- 1993-11-30 FI FI935350A patent/FI935350A/en unknown
-
1994
- 1994-10-18 EE EE9400271A patent/EE02994B1/en not_active IP Right Cessation
-
2001
- 2001-03-01 GR GR20010400329T patent/GR3035499T3/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE199317T1 (en) | 2001-03-15 |
LV10042A (en) | 1994-05-10 |
GR3035499T3 (en) | 2001-06-29 |
GB9111773D0 (en) | 1991-07-24 |
IE921938A1 (en) | 1992-12-02 |
US5464628A (en) | 1995-11-07 |
EE02994B1 (en) | 1997-06-16 |
NO307365B1 (en) | 2000-03-27 |
NO934261D0 (en) | 1993-11-25 |
GB2256135A (en) | 1992-12-02 |
FI935350A0 (en) | 1993-11-30 |
EP0586467A1 (en) | 1994-03-16 |
AU1780892A (en) | 1993-01-08 |
IE66188B1 (en) | 1995-12-13 |
LV10042B (en) | 1995-02-20 |
NO934261L (en) | 1993-11-25 |
LTIP111A (en) | 1994-03-25 |
EP0586467B1 (en) | 2001-02-28 |
LT3005B (en) | 1994-08-25 |
CA2110162A1 (en) | 1992-12-10 |
JP3269822B2 (en) | 2002-04-02 |
WO1992021334A1 (en) | 1992-12-10 |
DE69231709T2 (en) | 2001-10-04 |
DE69231709D1 (en) | 2001-04-05 |
FI935350A (en) | 1993-11-30 |
JPH06507618A (en) | 1994-09-01 |
CA2110162C (en) | 2002-11-12 |
GB2256135B (en) | 1995-01-18 |
DK0586467T3 (en) | 2001-03-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2154636T3 (en) | PHARMACEUTICAL COMPOSITIONS CONTAINING 4-SUBSTITUTED IMIDAZOLS FOR ADMINISTRATION BY TRANSDERMAL VIA. | |
ES8107185A1 (en) | Piperidine derivatives, their preparation and pharmaceutical compositions containing them. | |
BE904226A (en) | ANDROST-4-ENE-3,17-DIONE 4-SUBSTITUTED DERIVATIVES USEFUL IN PARTICULAR AS AROMATASE INHIBITORS AND THEIR MANUFACTURE. | |
DK0779886T3 (en) | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | |
GB1536515A (en) | Compositions containing silicon derivatives | |
KR970707108A (en) | (DI-TERT-BUTYLPHENOL COMPOUNDS WITH HETEROCYCLIC MOIETY, USEFUL AS ANTI-INFLAMMATORY AGENTS) | |
KR890016017A (en) | Substituted 1- (1H-imidazol-4-yl) alkyl-benzamide | |
ES8800145A1 (en) | Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same. | |
ES8305003A1 (en) | Androstane derivatives, process for their preparation and pharmaceutical compositions containing them. | |
DK601683D0 (en) | DIALKYLAMINOALCOXYBENZYL ALCOHOL DERIVATIVES | |
NO173057C (en) | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE BENZANILIDE DERIVATIVES | |
ME00300B (en) | NOVEL OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO/1,2-a/ /1,2/DIAZEPIN-1-CARBOXYLIC ACID DERIVATIVES, PREPARATION METHOD AND USE FOR PREPARING THERAPEUTICALLY ACTIVE COMPOUNDS | |
DE69303605D1 (en) | UNBREACHED BIS ARYL CARBINOL DERIVATIVES, COMPOSITIONS AND THEIR USE | |
ES8300675A1 (en) | Therapeutically active derivatives of phenylethanol amines. | |
DK601983D0 (en) | AMINOETHOXYBENZYL ALCOHOL DERIVATIVES | |
KR910021373A (en) | 1-phenoxycarbonyl-2-pyrrolidinone derivatives and psychotropic drugs |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 586467 Country of ref document: ES |