LT2864491T - Fermentai ir stireno sintezės būdai - Google Patents

Fermentai ir stireno sintezės būdai

Info

Publication number
LT2864491T
LT2864491T LTEP13806939.8T LT13806939T LT2864491T LT 2864491 T LT2864491 T LT 2864491T LT 13806939 T LT13806939 T LT 13806939T LT 2864491 T LT2864491 T LT 2864491T
Authority
LT
Lithuania
Prior art keywords
enzymes
methods
styrene synthesis
styrene
synthesis
Prior art date
Application number
LTEP13806939.8T
Other languages
English (en)
Inventor
Mohammad Wadud BHUIYA
Hui Chen
Xianpeng CAI
Jixiang Han
Xiaodan Yu
Original Assignee
Phytogene, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytogene, Inc. filed Critical Phytogene, Inc.
Publication of LT2864491T publication Critical patent/LT2864491T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/002—Preparation of hydrocarbons or halogenated hydrocarbons cyclic
    • C12P5/005—Preparation of hydrocarbons or halogenated hydrocarbons cyclic aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01005—Phenylalanine ammonia-lyase (4.3.1.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
LTEP13806939.8T 2012-06-22 2013-06-21 Fermentai ir stireno sintezės būdai LT2864491T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261663500P 2012-06-22 2012-06-22
PCT/US2013/047098 WO2013192543A2 (en) 2012-06-22 2013-06-21 Enzymes and methods for styrene synthesis

Publications (1)

Publication Number Publication Date
LT2864491T true LT2864491T (lt) 2018-12-27

Family

ID=49769723

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP13806939.8T LT2864491T (lt) 2012-06-22 2013-06-21 Fermentai ir stireno sintezės būdai

Country Status (8)

Country Link
US (2) US20150337336A1 (lt)
EP (1) EP2864491B1 (lt)
CN (1) CN104487581B (lt)
BR (1) BR112014031942A2 (lt)
DK (1) DK2864491T3 (lt)
ES (1) ES2709217T3 (lt)
LT (1) LT2864491T (lt)
WO (1) WO2013192543A2 (lt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014031942A2 (pt) 2012-06-22 2017-08-01 Phytogene Inc enzimas e métodos para síntese de estireno
EP3294760B1 (en) 2015-05-13 2021-03-24 Synlogic Operating Company, Inc. Bacteria engineered to reduce hyperphenylalaninemia
ES2925049T3 (es) * 2015-11-16 2022-10-13 Synlogic Operating Co Inc Bacterias manipuladas para reducir la hiperfenilalaninemia
CN111655841A (zh) 2017-06-21 2020-09-11 同生运营公司 用于治疗紊乱的细菌
CN109136158A (zh) * 2017-06-27 2019-01-04 中国科学院青岛生物能源与过程研究所 一种以生物质水解液为原料合成苯乙烯的基因工程菌及其构建方法与应用
CN111108204B (zh) * 2017-07-24 2024-02-23 国立研究开发法人理化学研究所 脱羧酶、和使用了该脱羧酶的不饱和烃化合物的制造方法
WO2021188819A1 (en) 2020-03-20 2021-09-23 Synlogic Operating Company, Inc. Microorganisms engineered to reduce hyperphenylalaninemia
CN116710549A (zh) * 2020-12-28 2023-09-05 国立研究开发法人理化学研究所 使用苯丙氨酸氨裂合酶的链状不饱和羧酸化合物的制造方法
US20250000957A1 (en) * 2021-09-16 2025-01-02 Arcturus Therapeutics, Inc. Compositions and methods for treating phenylketonuria
CN115960935A (zh) * 2022-09-30 2023-04-14 大连理工大学 一种利用阿魏酸脱羧酶高效催化肉桂酸合成苯乙烯的方法
CN115851797B (zh) * 2022-11-01 2024-12-10 大连理工大学 一种高效供给阿魏酸脱羧酶的辅因子prFMN的工程菌及构建方法与应用
CN118086266B (zh) * 2023-11-22 2024-10-25 大连理工大学 一种阿魏酸脱羧酶高活性组合突变体及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087557A (en) 1992-10-06 2000-07-11 The Salk Institute For Biological Studies Methods for the modulation of lignification levels
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
EP1589112A1 (en) * 2004-04-21 2005-10-26 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO Microbial production of aromatic acids
US20090311760A1 (en) 2006-05-17 2009-12-17 Schoemakerstraat 97 Host cells and uses thereof in the microbial production of hydroxylated aromatics
CN101397568A (zh) 2008-10-31 2009-04-01 云南大学 一种细菌阿魏酸脱羧酶基因及其晶体结构
US9150884B2 (en) * 2011-03-08 2015-10-06 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Microbial conversion of glucose to styrene and its derivatives
BR112014031942A2 (pt) 2012-06-22 2017-08-01 Phytogene Inc enzimas e métodos para síntese de estireno
WO2014202838A1 (en) * 2013-06-20 2014-12-24 Teknologian Tutkimuskeskus Vtt Methods for producing styrene and genetically modified micro-organisms related thereto
CN103865912B (zh) * 2014-02-24 2016-05-25 无锡新和源发酵技术研究院有限公司 一种阿魏酸脱羧酶晶体结构及其解析方法

Also Published As

Publication number Publication date
EP2864491A2 (en) 2015-04-29
BR112014031942A2 (pt) 2017-08-01
WO2013192543A3 (en) 2014-05-08
US20150337336A1 (en) 2015-11-26
US20180002726A1 (en) 2018-01-04
CN104487581A (zh) 2015-04-01
CN104487581B (zh) 2021-05-28
EP2864491A4 (en) 2016-05-11
ES2709217T3 (es) 2019-04-15
DK2864491T3 (en) 2018-12-17
EP2864491B1 (en) 2018-10-17
WO2013192543A2 (en) 2013-12-27
US10752921B2 (en) 2020-08-25

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