LT2555776T - Adenozino a1 agonistų ir neselektyvių beta adrenerginių receptorių blokatorių derinio kompozicijos, skirtos akispūdžio mažinimui - Google Patents

Adenozino a1 agonistų ir neselektyvių beta adrenerginių receptorių blokatorių derinio kompozicijos, skirtos akispūdžio mažinimui

Info

Publication number
LT2555776T
LT2555776T LTEP11757065.5T LT11757065T LT2555776T LT 2555776 T LT2555776 T LT 2555776T LT 11757065 T LT11757065 T LT 11757065T LT 2555776 T LT2555776 T LT 2555776T
Authority
LT
Lithuania
Prior art keywords
adenosine
agonists
intraocular pressure
adrenergic receptor
receptor blockers
Prior art date
Application number
LTEP11757065.5T
Other languages
English (en)
Inventor
Norman N. Kim
William K. Mcvicar
Thomas G. Mccauley
Original Assignee
Inotek Pharmaceuticals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corporation filed Critical Inotek Pharmaceuticals Corporation
Publication of LT2555776T publication Critical patent/LT2555776T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
LTEP11757065.5T 2010-03-19 2011-03-18 Adenozino a1 agonistų ir neselektyvių beta adrenerginių receptorių blokatorių derinio kompozicijos, skirtos akispūdžio mažinimui LT2555776T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31573110P 2010-03-19 2010-03-19
PCT/US2011/029012 WO2011116292A1 (en) 2010-03-19 2011-03-18 Combination compositions of adenosine a1 agonists and non-selective beta-adrenergic receptor blockers for reducing intraocular pressure

Publications (1)

Publication Number Publication Date
LT2555776T true LT2555776T (lt) 2017-04-25

Family

ID=44649621

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP11757065.5T LT2555776T (lt) 2010-03-19 2011-03-18 Adenozino a1 agonistų ir neselektyvių beta adrenerginių receptorių blokatorių derinio kompozicijos, skirtos akispūdžio mažinimui

Country Status (17)

Country Link
US (1) US8455457B2 (lt)
EP (1) EP2555776B1 (lt)
JP (1) JP2013522323A (lt)
CN (1) CN102958526A (lt)
CY (1) CY1118483T1 (lt)
DK (1) DK2555776T3 (lt)
ES (1) ES2613255T3 (lt)
HR (1) HRP20170009T1 (lt)
HU (1) HUE031530T2 (lt)
LT (1) LT2555776T (lt)
ME (1) ME02594B (lt)
PL (1) PL2555776T3 (lt)
PT (1) PT2555776T (lt)
RS (1) RS55616B1 (lt)
SI (1) SI2555776T1 (lt)
SM (1) SMT201700020B (lt)
WO (1) WO2011116292A1 (lt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2424546T3 (pl) * 2009-05-01 2016-04-29 Inotek Pharmaceuticals Corp Sposób obniżania ciśnienia wewnątrzgałkowego u ludzi
JP2013516495A (ja) * 2010-01-11 2013-05-13 イノテック ファーマシューティカルズ コーポレイション 眼圧を低下させる組合せ、キット、および方法
SG184221A1 (en) 2010-03-26 2012-10-30 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
PT2807178T (pt) 2012-01-26 2017-08-08 Inotek Pharmaceuticals Corp Polimorfos anidros de nitrato de (2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-dihidroxitetrahidrofuran-2-il)}metilo e seus processos de preparação
CN105188714A (zh) 2013-03-15 2015-12-23 伊诺泰克制药公司 眼用配制品
EP2968388A4 (en) * 2013-03-15 2016-10-19 Inotek Pharmaceuticals Corp METHOD FOR PROVIDING OCULAR NEUROPROTECTURE
EA201790851A1 (ru) * 2014-12-03 2017-11-30 Инотек Фармасьютикалз Корпорейшн Способы предотвращения, уменьшения и лечения макулодистрофии

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE418991T1 (de) * 2002-04-18 2009-01-15 Cv Therapeutics Inc Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker
GB2436255B (en) * 2002-12-23 2007-11-28 Global Cardiac Solutions Pty L Organ preconditioning, arrest, protection, preservation and recovery
EP1758596B9 (en) * 2004-05-26 2010-09-15 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
CN101010085B (zh) 2004-05-26 2012-12-26 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
AU2006320578B2 (en) * 2005-11-30 2013-01-31 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
WO2009076580A2 (en) * 2007-12-12 2009-06-18 Thomas Jefferson University Compositions and methods for the treatment and prevention of cardiovascular diseases
PL2424546T3 (pl) * 2009-05-01 2016-04-29 Inotek Pharmaceuticals Corp Sposób obniżania ciśnienia wewnątrzgałkowego u ludzi

Also Published As

Publication number Publication date
HUE031530T2 (en) 2017-07-28
EP2555776A4 (en) 2013-08-28
SI2555776T1 (sl) 2017-05-31
PT2555776T (pt) 2017-02-01
RS55616B1 (sr) 2017-06-30
ES2613255T3 (es) 2017-05-23
ME02594B (me) 2017-06-20
CY1118483T1 (el) 2017-07-12
EP2555776B1 (en) 2016-12-07
WO2011116292A1 (en) 2011-09-22
HRP20170009T1 (hr) 2017-03-10
CN102958526A (zh) 2013-03-06
DK2555776T3 (en) 2017-02-06
SMT201700020B (it) 2017-03-08
JP2013522323A (ja) 2013-06-13
US8455457B2 (en) 2013-06-04
PL2555776T3 (pl) 2017-08-31
EP2555776A1 (en) 2013-02-13
US20110251151A1 (en) 2011-10-13

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