LT2013104A - Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas - Google Patents

Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas

Info

Publication number
LT2013104A
LT2013104A LT2013104A LT2013104A LT2013104A LT 2013104 A LT2013104 A LT 2013104A LT 2013104 A LT2013104 A LT 2013104A LT 2013104 A LT2013104 A LT 2013104A LT 2013104 A LT2013104 A LT 2013104A
Authority
LT
Lithuania
Prior art keywords
factor
preparation
stem cell
granulocyte colony
partners
Prior art date
Application number
LT2013104A
Other languages
English (en)
Other versions
LT6161B (lt
Inventor
Henrikas Pesliakas
Plečkaitytė
Mištinienė
Žvirblytė
Petreikytė
Leiva
Stirkė
Žvirblis
Original Assignee
Uab Profarma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Profarma filed Critical Uab Profarma
Priority to LT2013104A priority Critical patent/LT6161B/lt
Priority to EP14727636.4A priority patent/EP3049433B1/en
Priority to PCT/LT2014/000006 priority patent/WO2015047062A1/en
Publication of LT2013104A publication Critical patent/LT2013104A/lt
Publication of LT6161B publication Critical patent/LT6161B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5431—IL-11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Išradime pateikiamas sulietų baltymų, konkrečiau granuliocitų kolonijas stimuliuojančio faktoriaus ir kamieninių ląstelių faktoriaus, sujungtų linkerine seka, heterodimerų gavimo būdas ir biologinės savybės. Išradimo multimerinės konstrukcijos gali būti naudojamos terapijoje, nes pasižymi sinergetiniu veikimu ir ilgesniu cirkuliacijos pusamžiu lyginant su kiekvienu iš monomerinių baltymų atskirai.
LT2013104A 2013-09-27 2013-09-27 Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas LT6161B (lt)

Priority Applications (3)

Application Number Priority Date Filing Date Title
LT2013104A LT6161B (lt) 2013-09-27 2013-09-27 Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas
EP14727636.4A EP3049433B1 (en) 2013-09-27 2014-04-15 Fused proteins of granulocyte colony-stimulating factor with other partners of growth factor, preferably with stem cell factor, and method of preparation thereof
PCT/LT2014/000006 WO2015047062A1 (en) 2013-09-27 2014-04-15 Fused proteins of granulocyte colony-stimulating factor with other partners of growth factor, preferably with stem cell factor, and method of preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LT2013104A LT6161B (lt) 2013-09-27 2013-09-27 Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas

Publications (2)

Publication Number Publication Date
LT2013104A true LT2013104A (lt) 2015-04-27
LT6161B LT6161B (lt) 2015-06-25

Family

ID=50877627

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2013104A LT6161B (lt) 2013-09-27 2013-09-27 Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas

Country Status (3)

Country Link
EP (1) EP3049433B1 (lt)
LT (1) LT6161B (lt)
WO (1) WO2015047062A1 (lt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017177981A1 (zh) * 2016-04-15 2017-10-19 江苏恒瑞医药股份有限公司 一种重组人粒细胞刺激因子的复性及纯化方法
WO2018176034A1 (en) * 2017-03-24 2018-09-27 Ohio State Innovation Foundation Modulators of notch signaling and methods of use thereof
CN109078617A (zh) * 2018-09-19 2018-12-25 生工生物工程（上海）股份有限公司 Gst纯化材料、制备方法和产品及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE194651T1 (de) 1989-10-16 2000-07-15 Amgen Inc Stammzellenfaktor
DK0546124T4 (da) * 1990-08-29 2003-05-19 Inst Genetics Llc Hæmatopoiese-stimulatorer med flere domæner
EP0503050A4 (en) 1990-09-28 1994-07-06 Ortho Pharma Corp Hybrid growth factors
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
WO1997012985A2 (en) 1995-10-05 1997-04-10 G.D. Searle & Co. Multi-functional hematopoietic receptor agonists
US6967092B1 (en) * 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
AU782496B2 (en) * 1999-07-13 2005-08-04 Bolder Biotechnology, Inc. Immunoglobulin fusion proteins
AUPQ934100A0 (en) 2000-08-10 2000-08-31 Mathers, Norman Ian Torque wrench
AP2006003491A0 (en) 2003-07-09 2006-02-28 Cipla Ltd Multi-dose inhaler.
AU2004262909B2 (en) 2003-07-29 2010-07-01 Dompe' S.P.A. Pharmaceutical combination of G-CSF and PlGF useful for blood stem cell
US7220407B2 (en) 2003-10-27 2007-05-22 Amgen Inc. G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
EP1527785A1 (en) 2003-10-27 2005-05-04 Ludwig-Maximilians-Universität München Use of G-CSF for treating ischemia
WO2006055260A2 (en) 2004-11-05 2006-05-26 Northwestern University Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders
CN100336907C (zh) * 2005-09-29 2007-09-12 南京大学 重组人血小板生成素/干细胞因子融合蛋白及其制备
EP1878739A1 (en) * 2006-07-14 2008-01-16 LEK Pharmaceuticals D.D. One step IMAC (MCAC) purification of proteins
CN102260343A (zh) * 2010-05-25 2011-11-30 健能隆医药技术（上海）有限公司 重组人g-csf二聚体在治疗神经损伤疾病中的用途
EP2742064B1 (en) * 2011-08-09 2016-07-27 UAB Profarma Derivatives of recombinant proteins, homo-multimers of granulocyte colony-stimulating factor and method of preparation thereof

Also Published As

Publication number Publication date
LT6161B (lt) 2015-06-25
EP3049433B1 (en) 2018-11-07
EP3049433A1 (en) 2016-08-03
WO2015047062A4 (en) 2015-05-21
WO2015047062A1 (en) 2015-04-02

Similar Documents

Publication Publication Date Title
EA201890729A1 (ru) Настраиваемые варианты доменов суперсемейства иммуноглобулинов и терапия сконструированными клетками
MX2019008521A (es) Heterociclos triciclicos como inhibidores de la proteina bet.
EA201890278A1 (ru) Антитела к pd-l1
GT201400057A (es) 3-pirmidin-4-il-oxazolidin-2-onas como inhibidores de la idh mutante
EA202090931A2 (ru) Композиции и способы перепрограммирования tcr с помощью гибридных белков
EA201690093A1 (ru) Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний
PH12015501493B1 (en) Anti-pdgfr-beta antibodies and uses thereof
EA201590085A1 (ru) Антитела анти-egfr и их применение
EA201491470A1 (ru) Композиции фактора viii и способы получения и использования подобных
WO2014145159A3 (en) Charge-engineered antibodies or compositions of penetration-enhanced targeting proteins and methods of use
EA201600252A1 (ru) Модифицированные антитела к рецепторам антиэпидермального фактора роста и способы их использования
EA201390803A1 (ru) Ингибиторы бромодомена и их применение
EA201400993A1 (ru) Антитела против рецептора эпидермального фактора роста, активные в определенных условиях, и способы их применения
EA201591524A1 (ru) Производные 2-аминопиримидина для лечения вирусных инфекций
JO3532B1 (ar) الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
EA201491856A1 (ru) Терапевтическое применение белков фактора роста фибробластов 21
EA201590962A1 (ru) Новые соединения
EA201792466A1 (ru) АНТИТЕЛА ПРОТИВ FcRn
CR20150585A (es) Anticuerpos anti-igf-1r con abolición de la unión al fcrn y su utilización en el tratamiento de enfermedades oculares vasculares
EA201690992A1 (ru) Антитела, специфичные к fcrn
EA201890933A2 (ru) ФАРМАЦЕВТИЧЕСКИЕ СОСТАВЫ, СПОСОБЫ, ТВЕРДЫЕ ФОРМЫ И СПОСОБЫ ПРИМЕНЕНИЯ, ОТНОСЯЩИЕСЯ К 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1H-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1H)-ОНУ
PH12015501870B1 (en) Nutritional compositions containing a peptide component with adiponectin stimulating properties and uses thereof
IN2014DN03213A (lt)
EA201591421A1 (ru) Препараты полипептида фактора ix
UA117933C2 (uk) Поліпептид, здатний зв'язувати с5-компонент комплементу людини

Legal Events

Date Code Title Description
BB1A Patent application published

Effective date: 20150427

FG9A Patent granted

Effective date: 20150625

PC9A Transfer of patents

Effective date: 20221005

MM9A Lapsed patents

Effective date: 20230927