LT2012062A - Kompozicijos, būdai ir susiję panaudojimai, skirti modifikuotos dnr skaldymui - Google Patents

Kompozicijos, būdai ir susiję panaudojimai, skirti modifikuotos dnr skaldymui

Info

Publication number
LT2012062A
LT2012062A LT2012062A LT2012062A LT2012062A LT 2012062 A LT2012062 A LT 2012062A LT 2012062 A LT2012062 A LT 2012062A LT 2012062 A LT2012062 A LT 2012062A LT 2012062 A LT2012062 A LT 2012062A
Authority
LT
Lithuania
Prior art keywords
compositions
methods
modified dna
related uses
cleaving
Prior art date
Application number
LT2012062A
Other languages
English (en)
Other versions
LT6019B (lt
Inventor
Zhenyu Zhu
Yu Zheng
Shengxi Guan
Hua Wang
Aine Quimby
Penghua Zhang
Lynne Apone
Original Assignee
New England Biolabs, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Biolabs, Inc. filed Critical New England Biolabs, Inc.
Publication of LT2012062A publication Critical patent/LT2012062A/lt
Publication of LT6019B publication Critical patent/LT6019B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Išradime aprašyta kompozicijos, būdai ir rinkinys, susiję su nauja fermentų šeima, kurie pirmenybiškai rišasi prie hidroksimetilinto citozino arba gliukozilinto hidroksimetilinto citozino ir skaldo dvigrandę DNR nustatytame atstume nuo atpažinimo vietos 3' galo, gaunant suskaldytus fragmentus su 1-3 bazių lipniais galais.
LT2012062A 2010-01-20 2012-07-16 Kompozicijos, būdai ir susiję panaudojimai, skirti modifikuotos dnr skaldymui LT6019B (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29663010P 2010-01-20 2010-01-20
US37693210P 2010-08-25 2010-08-25

Publications (2)

Publication Number Publication Date
LT2012062A true LT2012062A (lt) 2014-01-27
LT6019B LT6019B (lt) 2014-04-25

Family

ID=43797755

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2012062A LT6019B (lt) 2010-01-20 2012-07-16 Kompozicijos, būdai ir susiję panaudojimai, skirti modifikuotos dnr skaldymui

Country Status (5)

Country Link
US (1) US8969061B2 (lt)
DE (1) DE112011100297B4 (lt)
GB (1) GB2489187B (lt)
LT (1) LT6019B (lt)
WO (1) WO2011091146A1 (lt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010037001A2 (en) 2008-09-26 2010-04-01 Immune Disease Institute, Inc. Selective oxidation of 5-methylcytosine by tet-family proteins
WO2011025819A1 (en) 2009-08-25 2011-03-03 New England Biolabs, Inc. Detection and quantification of hydroxymethylated nucleotides in a polynucleotide preparation
EP2681335A1 (en) 2011-03-04 2014-01-08 Brachmann, Andreas Novel methods for detecting hydroxymethylcytosine
EP3425065B1 (en) 2011-12-13 2021-04-21 Oslo Universitetssykehus HF Methods and kits for detection of methylation status
US9200260B2 (en) 2012-03-15 2015-12-01 New England Biolabs, Inc. Compositions and methods for the transfer of a hexosamine to a modified nucleotide in a nucleic acid
US10081827B2 (en) 2012-03-15 2018-09-25 New England Biolabs, Inc. Mapping cytosine modifications
GB2523919B (en) * 2012-11-06 2017-07-05 New England Biolabs Inc Mapping cytosine modifications
CN104955960A (zh) 2012-11-30 2015-09-30 剑桥表现遗传学有限公司 用于修饰的核苷酸的氧化剂
US10597647B2 (en) 2013-06-28 2020-03-24 New England Biolabs, Inc. Compositions and methods for identifying hydroxymethylcytosine in a DNA
US20160194696A1 (en) * 2013-08-09 2016-07-07 New England Biolabs, Inc. Detecting, Sequencing and/or Mapping 5-Hydroxymethylcytosine and 5-Formylcytosine at Single-Base Resolution
US11459573B2 (en) 2015-09-30 2022-10-04 Trustees Of Boston University Deadman and passcode microbial kill switches
RU2742355C2 (ru) * 2016-04-07 2021-02-05 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити Неинвазивная диагностика путем секвенирования 5-гидроксиметилированной бесклеточной днк
KR20230083269A (ko) 2020-07-30 2023-06-09 캠브리지 에피제네틱스 리미티드 핵산 분석을 위한 조성물 및 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1046632A (en) 1911-11-27 1912-12-10 Martin Nesheim Spacing-tool.
GB8313232D0 (en) 1983-05-13 1983-06-22 Causton B E Prevention of undesired adsorption on surfaces
US5643758A (en) 1987-03-10 1997-07-01 New England Biolabs, Inc. Production and purification of a protein fused to a binding protein
US5475096A (en) 1990-06-11 1995-12-12 University Research Corporation Nucleic acid ligands
US5693502A (en) 1990-06-11 1997-12-02 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand inhibitors to DNA polymerases
US5874557A (en) 1990-06-11 1999-02-23 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand inhibitors to DNA polymerases
JPH05244946A (ja) 1992-03-03 1993-09-24 Akira Kaji 新規制限酵素
WO2000070100A1 (en) 1999-05-14 2000-11-23 New England Biolabs, Inc. Surface display of selenocysteine-containing peptides
AU2002251257B2 (en) 2001-04-10 2007-08-30 Ecole Polytechnique Federale De Lausanne Methods of Using O6-alkylguanine-DNA Alkyltransferases
US7825218B2 (en) 2006-04-14 2010-11-02 New England Biolabs, Inc. Solubilization and purification of a target protein fused to a mutant maltose-binding protein
US8208561B2 (en) 2006-07-27 2012-06-26 Telefonaktiebolaget Lm Ericsson (Publ) Technique for media frame decoding
WO2010037001A2 (en) 2008-09-26 2010-04-01 Immune Disease Institute, Inc. Selective oxidation of 5-methylcytosine by tet-family proteins
JP2013514758A (ja) 2008-12-23 2013-05-02 ニユー・イングランド・バイオレイブス・インコーポレイテツド 修飾ｄｎａを切断するための組成物、方法および関連する使用
WO2010114532A1 (en) 2009-04-01 2010-10-07 New England Biolabs, Inc. Solubilization and purification of a target protein fused to a mutant maltose-binding protein
WO2011025819A1 (en) 2009-08-25 2011-03-03 New England Biolabs, Inc. Detection and quantification of hydroxymethylated nucleotides in a polynucleotide preparation

Also Published As

Publication number Publication date
LT6019B (lt) 2014-04-25
DE112011100297T5 (de) 2013-01-31
GB201213167D0 (en) 2012-09-05
US20120301881A1 (en) 2012-11-29
US8969061B2 (en) 2015-03-03
WO2011091146A1 (en) 2011-07-28
DE112011100297B4 (de) 2017-08-24
GB2489187B (en) 2015-02-11
GB2489187A (en) 2012-09-19

Similar Documents

Publication Publication Date Title
LT2012062A (lt) Kompozicijos, būdai ir susiję panaudojimai, skirti modifikuotos dnr skaldymui
BRPI0823506A8 (pt) composições e métodos para a produção de isoprene
IN2012DN03825A (lt)
WO2010127304A3 (en) Sequencing methods
MX2010004674A (es) Variantes de alfa-amilasa con propiedades alteradas.
CA2884084C (en) Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
MX2013003681A (es) Ácidos nucleicos manipulados y métodos de uso de los mismos.
EP3633038A3 (en) Modulation of dystrophia myotonica-protein kinase (dmpk) expression
TR201901930T4 (tr) Topraktaki mikrobiyal aktivitenin geliştirilmesine yönelik bir yöntem.
WO2008024473A3 (en) Mapping of genomic interactions
ATE533838T1 (de) Verfahren zur verbesserten einführung von dna in bakterienzellen
WO2008094902A3 (en) Compositions and methods for the detection of a nucleic acid using a cleavage reaction
WO2010129019A3 (en) Real-time sequencing methods and systems
WO2007146819A3 (en) Methods for identifying and using snp panels
WO2010018563A3 (en) Compositions and methods for the prognosis of lymphoma
UA109418C2 (uk) Конструйований білок з цинковими пальцями, направлений на гени рослин, залучені до біосинтезу жирних кислот
MX2013001045A (es) Organoide hepatico, sus usos y metodo de cultivo para obtenerlos.
EP2094867A4 (en) METHODS AND COMPOSITIONS FOR DETECTION OF NUCLEIC ACID BY CLEAVAGE REACTION
WO2011160052A3 (en) Methods and compositions for sequence specific rna endonucleases
MX2009008461A (es) Variantes geneticas que contribuyen a riesgo de cancer de prostata.
WO2007111948A3 (en) Inhibitors of protein prenyltransferases
WO2010023310A3 (en) The an3 protein complex and its use for plant growth promotion
EA033514B1 (ru) Способы и композиции для анализа ahasl генов в пшенице
WO2008054514A3 (en) Differential expression profiling analysis of cell culture phenotypes and the uses thereof
WO2008157299A3 (en) Differential expression profiling analysis of cell culture phenotypes and uses thereof

Legal Events

Date Code Title Description
BB1A Patent application published

Effective date: 20140127

FG9A Patent granted

Effective date: 20140425

MM9A Lapsed patents

Effective date: 20220120