KR970061898A - Method for the preparation of cephalosporin intermediate - Google Patents

Method for the preparation of cephalosporin intermediate Download PDF

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Publication number
KR970061898A
KR970061898A KR1019960003242A KR19960003242A KR970061898A KR 970061898 A KR970061898 A KR 970061898A KR 1019960003242 A KR1019960003242 A KR 1019960003242A KR 19960003242 A KR19960003242 A KR 19960003242A KR 970061898 A KR970061898 A KR 970061898A
Authority
KR
South Korea
Prior art keywords
carboxylate
phenylacetamido
cephem
diphenylmethyl
formula
Prior art date
Application number
KR1019960003242A
Other languages
Korean (ko)
Other versions
KR100390548B1 (en
Inventor
민동원
김상호
Original Assignee
이웅열
주식회사 코오롱
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 이웅열, 주식회사 코오롱 filed Critical 이웅열
Priority to KR1019960003242A priority Critical patent/KR100390548B1/en
Publication of KR970061898A publication Critical patent/KR970061898A/en
Application granted granted Critical
Publication of KR100390548B1 publication Critical patent/KR100390548B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

본 발명은 세팔로스포린 항생제의 중간체로서 유용한 다음 일반식(Ⅰ)으로 표시되는 디페닐메틸 7β-페닐아세트아미도-3-(1-할로겐에테닐)-3-세펨-4-카르복실레이트-1-옥사이드를 제조하는 방법이다.The present invention relates to diphenylmethyl 7? -Phenylacetamido-3- (1-halogen ethenyl) -3-cephem-4-carboxylate-1-carboxylate represented by the following general formula (I) useful as an intermediate of cephalosporin antibiotic: Oxide. ≪ / RTI >

불활성 유기용매 중에서 일반식(Ⅱ)의 디페닐메틸 7β-페닐아세트아미도-3-(1-할로겐에테닐)-2-세펨-4-카르복실레이트와 피아세트산 또는 H2O2를 반응시켜 이를 정제하여 일반식(Ⅰ)의 디페닐메틸 7β-페닐아세트아미도-3-(1-할로겐에테닐)-3-세펨-4-카르복실레이트-1-옥사이드를 제조한다.Reacting diphenylmethyl 7? -Phenylacetamido-3- (1-halogen ethenyl) -2-cephem-4-carboxylate of the formula (II) with picatric acid or H 2 O 2 in an inert organic solvent This is purified to prepare diphenylmethyl 7? -Phenylacetamido-3- (1-halogenethenyl) -3-cephem-4-carboxylate-1-oxide of the general formula (I).

윗식에서 R1은 Cl 또는 Br이다.In the above formula, R 1 is Cl or Br.

Description

세팔로스포린 중간체의 제조방법Method for the preparation of cephalosporin intermediate

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (1)

불활성 유기용매 중에서 일반식(Ⅱ)의 디페닐메틸 7β-페닐아세트 아미도-3-(1-할로겐에테닐)-2-세펨-4-카르복실레이트와 퍼아세트산 또는 H2O2를 반응시켜서 일반식(Ⅰ)의 디페닐메틸 7β-페닐아세트 아미도-3-(1-할로겐에테닐)-3-세펨-4-카르복실레이트-1-옥사이드를 제조하는 방법.Reacting diphenylmethyl 7? -Phenylacetamido-3- (1-halogen ethenyl) -2-cephem-4-carboxylate of the formula (II) with peracetic acid or H 2 O 2 in an inert organic solvent A process for preparing diphenylmethyl 7? -Phenylacetamido-3- (1-halogenethenyl) -3-cephem-4-carboxylate-1-oxide of the general formula (I). 윗 식에서 R1은 Cl 또는 Br이다.In the above formula, R 1 is Cl or Br. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960003242A 1996-02-10 1996-02-10 Method for manufacturing cephalosporin intermediate KR100390548B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019960003242A KR100390548B1 (en) 1996-02-10 1996-02-10 Method for manufacturing cephalosporin intermediate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960003242A KR100390548B1 (en) 1996-02-10 1996-02-10 Method for manufacturing cephalosporin intermediate

Publications (2)

Publication Number Publication Date
KR970061898A true KR970061898A (en) 1997-09-12
KR100390548B1 KR100390548B1 (en) 2003-11-13

Family

ID=37421857

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960003242A KR100390548B1 (en) 1996-02-10 1996-02-10 Method for manufacturing cephalosporin intermediate

Country Status (1)

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KR (1) KR100390548B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106866703A (en) * 2017-04-28 2017-06-20 山东新华制药股份有限公司 The preparation method of Cefradine oxide D

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4266049A (en) * 1980-02-20 1981-05-05 Eli Lilly And Company Process for 3-iodomethyl cephalosporins
GB2125807B (en) * 1982-05-26 1986-01-08 Lilly Industries Ltd Preparation of penicillin and cephalosporin compounds and novel intermediates useful therein
JPH05148272A (en) * 1991-11-27 1993-06-15 Shionogi & Co Ltd Carboxyvinyloxyiminocephalosporins

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Publication number Publication date
KR100390548B1 (en) 2003-11-13

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