KR19990009210A - Method for preparing cisapride - Google Patents

Method for preparing cisapride Download PDF

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Publication number
KR19990009210A
KR19990009210A KR1019970031541A KR19970031541A KR19990009210A KR 19990009210 A KR19990009210 A KR 19990009210A KR 1019970031541 A KR1019970031541 A KR 1019970031541A KR 19970031541 A KR19970031541 A KR 19970031541A KR 19990009210 A KR19990009210 A KR 19990009210A
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KR
South Korea
Prior art keywords
formula
compound
preparation
present
provides
Prior art date
Application number
KR1019970031541A
Other languages
Korean (ko)
Other versions
KR100207096B1 (en
Inventor
김기원
오경문
김용진
Original Assignee
이명환
일동제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 이명환, 일동제약 주식회사 filed Critical 이명환
Priority to KR1019970031541A priority Critical patent/KR100207096B1/en
Publication of KR19990009210A publication Critical patent/KR19990009210A/en
Application granted granted Critical
Publication of KR100207096B1 publication Critical patent/KR100207096B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Abstract

본 발명은 위장기능 조절제로 유용한 구조식(Ⅰ)의 시스-4-아미노-5-클로로-N-[1-[3-(4-플루오로페녹시)프로필]-3-메톡시-4-피페리딘일]-2-메톡시벤즈아미드를 제조하는 진보된 신규방법에 관한 것으로, 구조식(Ⅳ)의 화합물을 선택적 환원반응시켜 높은 수율과 고순도로 구조식(Ⅰ) 화합물을 제조하는 방법을 제공한다.The present invention provides cis-4-amino-5-chloro-N- [1- [3- (4-fluorophenoxy) propyl] -3-methoxy-4-py of formula (I) useful as a gastrointestinal modulator. The present invention relates to an advanced novel process for the preparation of ferridinyl] -2-methoxybenzamide, which provides a process for the preparation of the compound of formula (I) with high yield and high purity by selective reduction of the compound of formula (IV).

Description

시사프라이드의 제조 방법Method for preparing cisapride

본 발명은 위장기능 조절제로 유용한 다음 구조식(Ⅰ)의 화합물, 즉, 시스-4-아미노-5-클로로-N[1-[3-(4-플루오로페녹시)프로필]-3-메톡시-4-피페리딘일]-2-메톡시벤즈아미드(일반명 : 시사프라이드)를 제조하는 신규 방법에 관한 것이다.The present invention provides compounds of formula (I), ie cis-4-amino-5-chloro-N [1- [3- (4-fluorophenoxy) propyl] -3-methoxy, useful as gastrointestinal modulators. -4-piperidinyl] -2-methoxybenzamide (common name: cisapride).

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Claims (1)

구조식(Ⅵ) 화합물을 선택적으로 환원반응시켜 구조식(Ⅰ)의 화합물을 제조하는 방법A method for preparing the compound of formula (I) by selectively reducing the compound of formula (VI)
KR1019970031541A 1997-07-08 1997-07-08 Process for the preparation of cisapride KR100207096B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019970031541A KR100207096B1 (en) 1997-07-08 1997-07-08 Process for the preparation of cisapride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019970031541A KR100207096B1 (en) 1997-07-08 1997-07-08 Process for the preparation of cisapride

Publications (2)

Publication Number Publication Date
KR19990009210A true KR19990009210A (en) 1999-02-05
KR100207096B1 KR100207096B1 (en) 1999-07-15

Family

ID=19513720

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970031541A KR100207096B1 (en) 1997-07-08 1997-07-08 Process for the preparation of cisapride

Country Status (1)

Country Link
KR (1) KR100207096B1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100493671B1 (en) * 1998-09-10 2005-08-31 한국타이어 주식회사 Steel Cords for Radial Tires
JP2010138206A (en) * 2000-08-01 2010-06-24 Novexel Novel heterocyclic compound

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100493671B1 (en) * 1998-09-10 2005-08-31 한국타이어 주식회사 Steel Cords for Radial Tires
JP2010138206A (en) * 2000-08-01 2010-06-24 Novexel Novel heterocyclic compound

Also Published As

Publication number Publication date
KR100207096B1 (en) 1999-07-15

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