KR970043019A - Novel Ganoderma Lucidum Mushroom, Polysaccharides Secreted from It, and Liver Fibrosis Inhibitory Composition Containing the Same - Google Patents

Novel Ganoderma Lucidum Mushroom, Polysaccharides Secreted from It, and Liver Fibrosis Inhibitory Composition Containing the Same Download PDF

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KR970043019A
KR970043019A KR1019960065806A KR19960065806A KR970043019A KR 970043019 A KR970043019 A KR 970043019A KR 1019960065806 A KR1019960065806 A KR 1019960065806A KR 19960065806 A KR19960065806 A KR 19960065806A KR 970043019 A KR970043019 A KR 970043019A
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ganoderma lucidum
polysaccharide
liver fibrosis
kctc
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KR100190756B1 (en
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손동환
김재백
고건일
박은전
송치현
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이병언
주식회사 중외제약
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
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    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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Abstract

본 발명은 영지버섯(Ganoderma lucidum) WK-003 (KCTC 0179BP), 그로부터 분비되며, 간 기능 보호작용이 우수함과 동시에 간독성을 일으키지 않는 다당류, 이의 생산방법, 및 이를 함유하는 간섬유화 억제용 조성물을 제공한다. 본 발명에 따른 다당류는 우수한 간보호 작용을 나타내면서, 간 독성을 일으키지 않으므로 안전하게 사용될 수 있다.The present invention Ganoderma lucidum WK-003 (KCTC 0179BP), secreted therefrom, provides a polysaccharide, a production method thereof, and a composition for inhibiting hepatic fibrosis, which is excellent in protecting the liver function and does not cause hepatotoxicity. do. The polysaccharide according to the present invention can be used safely because it exhibits excellent hepatoprotective action and does not cause liver toxicity.

Description

신규 영지버섯, 그로부터 분비된 다당류 및 이를 함유하는 간 섬유화 억제 조성물Novel Ganoderma Lucidum Mushroom, Polysaccharides Secreted from It, and Liver Fibrosis Inhibitory Composition Containing the Same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

도 1A - 1D 내지 도 3A - 3D는 각각 영지버섯 진흥 1호(A), 진흥 2호(B), IY-009(C) 및 본 발명의 균주 WK-003 (D)을 형태적으로 관찰한 사진으로서,1A-1D to 3A-3D are morphological observations of Ganoderma lucidum promotion No. 1 (A), promotion No. 2 (B), IY-009 (C) and strain WK-003 (D) of the present invention, respectively. As a photo,

도 1은 측면에서 관찰한 결과.Figure 1 is observed from the side.

Claims (7)

간 보호작용이 있는 다당류 생산능을 갖는 영지버섯 (Ganoderma lucidum) WK-003 (KCTC 0179BP).Ganoderma lucidum WK-003 (KCTC 0179BP) with polysaccharide-producing ability with liver protection. 제 1항에 있어서, 상기 다당류는 퓨코스 0-2.5중량%, 프럭토스 0-5중량%, 글루코스 18-80.2중량%, 만노스5-60중량%, 갈락토오스 0-10.5중량%, 아라비노스 0-15중량%, 람노스 0-20중량% 및 자일로스 0-10중량%의 당조성을 갖는 것임을 특징으로 하는 영지버섯(Ganoderma lucidum) WK-003 (KCTC 0179BP).According to claim 1, wherein the polysaccharide is 0-2.5% by weight of fucose, 0-5% by weight fructose, 18-80.2% by weight glucose, mannose 5-60% by weight, galactose 0-10.5%, arabinose 0- Ganoderma lucidum WK-003 (KCTC 0179BP), characterized in that it has a sugar composition of 15% by weight, 0-20% by weight of rhamnose and 0-10% by weight of xylose. 영지버섯(Ganoderma lucidum) WK-003 (KCTC 0179BP)로부터 분비되며, 퓨코스 0-2.5중량%, 프럭토스 0-5중량%, 글루코스 18-80.2중량%, 만노스5-60중량%, 갈락토오스 0-10.5중량%, 아라비노스 0-15중량%, 람노스 0-20중량% 및 자일로스 0-10중량%의 당조성을 갖고, 간 보호 작용을 나타냄을 특징으로 하는 다당류.It is secreted from Ganoderma lucidum WK-003 (KCTC 0179BP), 0-2.5% by weight of fucose, 0-5% by weight of fructose, 18-80.2% by weight of glucose, mannose 5-60% by weight, galactose 0- A polysaccharide having a sugar composition of 10.5% by weight, 0-15% by weight of arabinose, 0-20% by weight of rhamnose and 0-10% by weight of xylose, and exhibits hepatoprotective action. 제 3항에 있어서, 퓨코스 0-2.5중량%, 프럭토스 0-4.5중량%, 글루코스 35-70중량%, 만노스 0-20중량%, 갈락토오스 3-50중량%, 아라비노스 0-3중량%, 람노스 0-5중량% 및 자일로스 3-10중량%의 당조성을 갖는 것을특징으로 하는 다당류.According to claim 3, wherein 0-2.5% by weight of fucose, 0-4.5% by weight of fructose, 35-70% by weight of glucose, 0-20% by weight of mannose, 3-50% by weight of galactose, 0-3% by weight of arabinose. , Polysaccharide characterized by having a sugar composition of 0-5% by weight of rhamnose and 3-10% by weight of xylose. 영지버섯(Ganoderma lucidum) WK-003 (KCTC 0179BP)를 배양배지에서 배양하여 배지에 다당류를 축적하는 단계; 배양액으로부터 영지버섯 균사체를 제거하고 상등액을 회수하는 단계; 및 배양 상등액으로부터 다당류를 분리하는 단계를 포함함을 특징으로 하는 간 섬유화 억제능을 갖는 다당류의 생산방법.Culturing Ganoderma lucidum WK-003 (KCTC 0179BP) in a culture medium to accumulate polysaccharides in the medium; Removing the Ganoderma lucidum mycelium from the culture and recovering the supernatant; And separating the polysaccharide from the culture supernatant. 제 5항에 있어서, 배양은 약 2-5의 pH에서 실시함을 특징으로 하는 생산방법.The method of claim 5, wherein the culturing is conducted at a pH of about 2-5. 제 3항의 다당류를 간 섬유화를 억제하기에 유효한 양으로 함유함을 특징으로 하는 간 섬유화 억제용 조성물.A composition for inhibiting liver fibrosis, comprising the polysaccharide of claim 3 in an amount effective to inhibit liver fibrosis.
KR1019960065806A 1995-12-16 1996-12-14 Novel strain of ganodrema lucidum, polysaccharides from it, and a liver protecting composition containing the polysaccharides KR100190756B1 (en)

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KR19950051043 1995-12-16
KR1995-51043 1995-12-16
KR101995051043 1995-12-16

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100663712B1 (en) * 2005-05-24 2007-01-03 (주)새롬바이오 A crude exopolysaccharides produced from Phellinus baumii mycellium having hypoglycemic activity and preparation method thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101074158B1 (en) * 2008-04-07 2011-10-17 재단법인 한국원자력의학원 Composition comprising polysaccharide extracted from panax ginseng preventing and treating liver diseases
CN103977040A (en) * 2014-05-15 2014-08-13 济南康众医药科技开发有限公司 Lucid ganoderma drying method
CN107602719B (en) * 2017-10-20 2020-12-29 广东粤微食用菌技术有限公司 Ganoderma lucidum fruiting body refined polysaccharide with significant auxiliary anti-tumor activity and preparation method and application thereof
CN107722131B (en) * 2017-10-20 2020-12-29 广东粤微食用菌技术有限公司 Total ganoderma lucidum spore powder refined polysaccharide with significant auxiliary antitumor activity and preparation method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100663712B1 (en) * 2005-05-24 2007-01-03 (주)새롬바이오 A crude exopolysaccharides produced from Phellinus baumii mycellium having hypoglycemic activity and preparation method thereof

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