CA2171712A1 - Natamycin Recovery - Google Patents

Natamycin Recovery

Info

Publication number
CA2171712A1
CA2171712A1 CA2171712A CA2171712A CA2171712A1 CA 2171712 A1 CA2171712 A1 CA 2171712A1 CA 2171712 A CA2171712 A CA 2171712A CA 2171712 A CA2171712 A CA 2171712A CA 2171712 A1 CA2171712 A1 CA 2171712A1
Authority
CA
Canada
Prior art keywords
natamycin
extraction
temperature
extraction medium
maintaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2171712A
Other languages
French (fr)
Other versions
CA2171712C (en
Inventor
Phillip Terry Olson
James R. Millis
Michael Henry Reimer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIO-TECHNICAL RESOURCES LP
Original Assignee
Phillip Terry Olson
James R. Millis
Michael Henry Reimer
Bio-Technical Resources L.P.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27382575&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2171712(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phillip Terry Olson, James R. Millis, Michael Henry Reimer, Bio-Technical Resources L.P. filed Critical Phillip Terry Olson
Publication of CA2171712A1 publication Critical patent/CA2171712A1/en
Application granted granted Critical
Publication of CA2171712C publication Critical patent/CA2171712C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/626—Natamycin; Pimaricin; Tennecetin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A process for the recovery of high purity natamycin from fermentation broth by extraction with methanol is disclosed. In one embodiment the process comprises the steps: (1) adding methanol to a natamycin feed stream comprising at least 2g/L of solid suspended natamycin to form an extraction medium, and maintaining the extraction medium at a temperature of 0-25°C, preferably not over l5°C;
(2) adjusting the pH of the extraction medium to 1.0 to 4.5 while maintaining the temperature at 0-25°C for O.5 to 30 hours, but preferably not over O.5 hour when the temperature is l5-25°C; (3) removing solids from the extraction medium to form an extraction liquor; (4) raising the pH of the extraction liquor to 6.0-9.0; and (5) recovering precipitated natamycin.
CA002171712A 1993-09-17 1994-09-16 Natamycin recovery Expired - Lifetime CA2171712C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US12114593A 1993-09-17 1993-09-17
US12114293A 1993-09-17 1993-09-17
US08/121,145 1993-09-17
US08/121,142 1993-09-17
US08/237,473 1994-05-03
US08/237,473 US5591438A (en) 1990-12-07 1994-05-03 Natamycin recovery

Publications (2)

Publication Number Publication Date
CA2171712A1 true CA2171712A1 (en) 1995-03-23
CA2171712C CA2171712C (en) 1999-03-16

Family

ID=27382575

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002171712A Expired - Lifetime CA2171712C (en) 1993-09-17 1994-09-16 Natamycin recovery

Country Status (9)

Country Link
US (1) US5591438A (en)
EP (1) EP0719344A1 (en)
JP (2) JP3856337B2 (en)
CN (1) CN1056650C (en)
AU (1) AU7834294A (en)
BR (1) BR9407695A (en)
CA (1) CA2171712C (en)
PL (1) PL313481A1 (en)
WO (1) WO1995007998A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902579A (en) * 1991-08-05 1999-05-11 Bio-Technical Resources Natamycin-containing streptomyces biomass and its use in animal feed
US5942611A (en) * 1995-01-19 1999-08-24 Cultor Ltd. Process for natamycin recovery
GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
ATE239091T1 (en) * 1996-02-09 2003-05-15 Dsm Nv NATAMYCIN EXTRACTION
US6150143A (en) * 1996-02-09 2000-11-21 Gist-Brocades B.V. Natamycin recovery
FR2791256B1 (en) 1999-03-26 2001-08-31 Oreal OXIDATION DYEING PROCESS USING N-ACETYLCYSTEINE AS A REDUCING AGENT AND A LACCASE AS AN OXIDIZING AGENT
US6653469B1 (en) 2002-06-20 2003-11-25 Murty Pharmaceuticals, Inc. Antibiotic purification method
KR100461577B1 (en) * 2002-12-04 2004-12-17 주식회사 바이오알앤즈 Purification process of a natamycin
KR100512331B1 (en) * 2002-12-04 2005-09-05 경상남도 Preparation of natamycin from Streptomyces natalensis
EP1641343A1 (en) 2003-06-02 2006-04-05 DSM IP Assets B.V. Stable aqueous solution of natamycin fungicide
EP2374897B1 (en) * 2004-10-28 2014-10-15 DSM IP Assets B.V. Stable needle-shaped crystals of natamycin
CN101062934B (en) * 2007-05-31 2010-05-19 山东鲁抗医药股份有限公司 Method for extracting natamycin from fermentation technique culture
CN112585150B (en) * 2018-08-16 2024-03-29 帝斯曼知识产权资产管理有限公司 New epoxypolyene ampholytic macrolides and process for purifying natamycin
US11623939B2 (en) 2018-08-16 2023-04-11 Dsm Ip Assets B.V. All-trans polyene amphoteric macrolide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892850A (en) * 1956-03-13 1975-07-01 Gist Brocades Nv Pimaricin and process of producing same
GB844289A (en) * 1956-03-13 1960-08-10 Konink Nl Gist & Spiritusfabri Pimaricin and process of producing same
GB846933A (en) * 1956-07-23 1960-09-07 American Cyanamid Co New antifungal substance, pimaricin, and method of producing same
US3378441A (en) * 1963-10-17 1968-04-16 S B Penick & Company Tetraene antibiotic purification
US4006222A (en) * 1975-10-20 1977-02-01 E. R. Squibb & Sons, Inc. Purification of nystatin
US4308375A (en) * 1980-10-06 1981-12-29 E. R. Squibb & Sons, Inc. Method for purifying water-insoluble polyene antibiotics
EP0563269B1 (en) * 1990-12-07 1994-10-12 E.I. Du Pont De Nemours And Company Natamycin recovery
CA2115036C (en) * 1991-08-05 2002-11-12 Phillip T. Olson Continuous natamycin production
ZA925876B (en) * 1991-08-05 1994-02-07 Bio Tech Resources A fermentation process for producing natamycin
US5231014A (en) * 1991-08-05 1993-07-27 Bio-Technical Resources Fermentation process for producing natamycin

Also Published As

Publication number Publication date
JPH09509042A (en) 1997-09-16
US5591438A (en) 1997-01-07
CA2171712C (en) 1999-03-16
CN1056650C (en) 2000-09-20
JP3856337B2 (en) 2006-12-13
JP2006296430A (en) 2006-11-02
CN1135239A (en) 1996-11-06
BR9407695A (en) 1997-02-04
AU7834294A (en) 1995-04-03
WO1995007998A1 (en) 1995-03-23
EP0719344A1 (en) 1996-07-03
PL313481A1 (en) 1996-07-08

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Effective date: 20140916