CA2127381A1 - Process for the Isolation and Purification of Mevinolin - Google Patents

Process for the Isolation and Purification of Mevinolin

Info

Publication number
CA2127381A1
CA2127381A1 CA2127381A CA2127381A CA2127381A1 CA 2127381 A1 CA2127381 A1 CA 2127381A1 CA 2127381 A CA2127381 A CA 2127381A CA 2127381 A CA2127381 A CA 2127381A CA 2127381 A1 CA2127381 A1 CA 2127381A1
Authority
CA
Canada
Prior art keywords
mevinolin
fermentation liquor
isolation
purification
biomass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2127381A
Other languages
French (fr)
Other versions
CA2127381C (en
Inventor
Vilmos Keri
Eva Ilkoy
Irma Hogye
Ilona Bagdi
Gabor Ambrus
Attila Jakab
Istvan Szabo
Janos Balint
Zsuzsanna Scheidl
Etelka Deli
Gyula Horvath
Csaba Szabo
Ildiko Lang
Imre Szekely
Imre Moravcsik
Vera Kovacs
Szabolcs Matyas
Zsuzsanna Sztaray
Laszlo Eszenyi
Antonia Jekkel
Attila Andor
Lajos Deak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2127381A1 publication Critical patent/CA2127381A1/en
Application granted granted Critical
Publication of CA2127381C publication Critical patent/CA2127381C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Abstract

In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin from the separated fermentation liquor, and recovering the end product, the improvement which comprises carryingout the dissolving at a pH between about 7.5 and about 10, and the separating of the mevinolin is carried out at a pH between about 4.5 and about 1.
CA002127381A 1992-11-04 1993-09-08 Process for the isolation and purification of mevinolin Expired - Fee Related CA2127381C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9203458A HU210867B (en) 1992-11-04 1992-11-04 Method for extraction and purification of mevinolin from culture medium
HUP9203458 1992-11-04

Publications (2)

Publication Number Publication Date
CA2127381A1 true CA2127381A1 (en) 1994-05-11
CA2127381C CA2127381C (en) 1997-12-23

Family

ID=10982513

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002127381A Expired - Fee Related CA2127381C (en) 1992-11-04 1993-09-08 Process for the isolation and purification of mevinolin

Country Status (8)

Country Link
AT (1) AT401060B (en)
CA (1) CA2127381C (en)
DE (2) DE4395515C2 (en)
ES (1) ES2081776B1 (en)
GR (1) GR930100408A (en)
HU (1) HU210867B (en)
IT (1) IT1266672B1 (en)
WO (1) WO1994010328A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
AU7271696A (en) * 1995-12-06 1997-06-27 Antibiotic Co Method of production of lovastatin
SK282679B6 (en) * 1999-04-16 2002-11-06 Biotika, A. S. Process of isolation of lovastatin from fermentation broth
RU2265665C2 (en) * 2000-02-24 2005-12-10 Тева Джиоджисзерджиар Ресзвенитаршашаг Method for purifying fermentation broth
JP2003525935A (en) * 2000-03-03 2003-09-02 ビオガル ジョジセルジャール アール テー． Method for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
ES2204285B1 (en) * 2002-05-20 2005-03-01 Ercros Industrial, S.A. PROCEDURE FOR THE INSULATION AND PURIFICATION OF LOVASTATIN.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (en) * 1979-02-20 1984-06-19 三共株式会社 New physiologically active substance monacolin K and its production method
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
HU208997B (en) * 1992-06-17 1994-02-28 Gyogyszerkutato Intezet Microbiological method for producing mevinoline

Also Published As

Publication number Publication date
IT1266672B1 (en) 1997-01-09
WO1994010328A1 (en) 1994-05-11
AT401060B (en) 1996-06-25
ES2081776A1 (en) 1996-03-01
DE4395515T1 (en) 1994-12-01
GR930100408A (en) 1994-07-29
ES2081776B1 (en) 1996-10-16
ITMI932343A0 (en) 1993-11-04
DE4395515C2 (en) 1999-06-17
HU210867B (en) 1995-10-30
ATA901593A (en) 1995-10-15
CA2127381C (en) 1997-12-23
ITMI932343A1 (en) 1995-05-04

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