GR930100408A - Process for the isolation and purification of mevinolin - Google Patents

Process for the isolation and purification of mevinolin

Info

Publication number
GR930100408A
GR930100408A GR930100408A GR930100408A GR930100408A GR 930100408 A GR930100408 A GR 930100408A GR 930100408 A GR930100408 A GR 930100408A GR 930100408 A GR930100408 A GR 930100408A GR 930100408 A GR930100408 A GR 930100408A
Authority
GR
Greece
Prior art keywords
separating
mevinolin
isolation
purification
active ingredient
Prior art date
Application number
GR930100408A
Other languages
Greek (el)
Inventor
Gabor Ambrus
Attila Andor
Ilona Bagdi
Janos Balint
Lajos Deak
Etelka Deli
Laszlo Eszenyi
Irma Hogye
Gyula Horvath
Eva Ilkoy
Attila Jakab
Antonia Jekkel
Vilmos Keri
Vera Kovacs
Ildiko Lang
Szabolcs Matyas
Imre Moravcsik
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of GR930100408A publication Critical patent/GR930100408A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η παρούσα εφεύρεση αφορά μέθοδο διαχωρισμού μεμβινολίνης δια διαλύσεως του δραστικού συστατικού από την εντός του υγρού ζυμώσεως βιομάζα και στη συνέχει δια διαχωρισμού αυτού από το διηθηθέν υγρο ζυμώσεως, η οποία περιλαμβάνει την διεξαγωγή της διαλυτοποιήσεως σε τιμή PH μεταξύ 7,5 και 10,0, κατά προτίμηση μεταξύ 8,0 και 9,0, τον διαχωρισμό του δραστικού συστατικού από το διηθηθέν υγρό σε τιμή ΡΗ μεταξύ 4,5 και 1,0, κατά προτίμηση μεταξύ 2,2 και 2,0, την διήθηση και τον καθαρισμό αυτού δια μεθόδων γνωστών γι' ατό, κατά προτίμηση δι' ανακρυσταλλώσεως.ωThe present invention relates to a method for separating membinoline by dissolving the active ingredient from the biomass in the fermentation liquid and subsequently by separating it from the filtered fermentation liquid, which includes carrying out the solubilization at a PH value between 7.5 and 10.0, preferably between 8.0 and 9.0, separating the active ingredient from the filtered liquid at a pH value between 4.5 and 1.0, preferably between 2.2 and 2.0, filtering and purifying it by methods known therefor, preferably by recrystallization.o

GR930100408A 1992-11-04 1993-10-18 Process for the isolation and purification of mevinolin GR930100408A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9203458A HU210867B (en) 1992-11-04 1992-11-04 Method for extraction and purification of mevinolin from culture medium

Publications (1)

Publication Number Publication Date
GR930100408A true GR930100408A (en) 1994-07-29

Family

ID=10982513

Family Applications (1)

Application Number Title Priority Date Filing Date
GR930100408A GR930100408A (en) 1992-11-04 1993-10-18 Process for the isolation and purification of mevinolin

Country Status (8)

Country Link
AT (1) AT401060B (en)
CA (1) CA2127381C (en)
DE (2) DE4395515T1 (en)
ES (1) ES2081776B1 (en)
GR (1) GR930100408A (en)
HU (1) HU210867B (en)
IT (1) IT1266672B1 (en)
WO (1) WO1994010328A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
AU7271696A (en) * 1995-12-06 1997-06-27 Antibiotic Co Method of production of lovastatin
SK282679B6 (en) * 1999-04-16 2002-11-06 Biotika, A. S. Process of isolation of lovastatin from fermentation broth
CZ20022779A3 (en) * 2000-02-24 2003-02-12 Biogal Gyogyszergyar Rt. Purification process of fermentation broth
AU4183301A (en) * 2000-03-03 2001-09-17 Biogal Gyogyszergyar A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
ES2204285B1 (en) * 2002-05-20 2005-03-01 Ercros Industrial, S.A. PROCEDURE FOR THE INSULATION AND PURIFICATION OF LOVASTATIN.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (en) * 1979-02-20 1984-06-19 三共株式会社 New physiologically active substance monacolin K and its production method
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus
HU208997B (en) * 1992-06-17 1994-02-28 Gyogyszerkutato Intezet Microbiological method for producing mevinoline

Also Published As

Publication number Publication date
DE4395515C2 (en) 1999-06-17
ES2081776A1 (en) 1996-03-01
ITMI932343A0 (en) 1993-11-04
HU210867B (en) 1995-10-30
CA2127381A1 (en) 1994-05-11
IT1266672B1 (en) 1997-01-09
ITMI932343A1 (en) 1995-05-04
AT401060B (en) 1996-06-25
ATA901593A (en) 1995-10-15
ES2081776B1 (en) 1996-10-16
CA2127381C (en) 1997-12-23
DE4395515T1 (en) 1994-12-01
WO1994010328A1 (en) 1994-05-11

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