KR970032882A - Extraction and Purification of Active Active Ingredients from Abdominal Herbal Medicines and Herbal Medicine Compositions Containing the Extracts - Google Patents

Extraction and Purification of Active Active Ingredients from Abdominal Herbal Medicines and Herbal Medicine Compositions Containing the Extracts Download PDF

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KR970032882A
KR970032882A KR1019960043017A KR19960043017A KR970032882A KR 970032882 A KR970032882 A KR 970032882A KR 1019960043017 A KR1019960043017 A KR 1019960043017A KR 19960043017 A KR19960043017 A KR 19960043017A KR 970032882 A KR970032882 A KR 970032882A
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extract
herbal medicine
herbal
water
mixed
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KR0180567B1 (en
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곽의종
한창균
김환수
안재석
김택수
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김준웅
주식회사 선경인더스트리
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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Abstract

본 발명은 복방 생약제로부터 유효활성 성분의 추출·정제방법과 그 추출물을 함유한 생약 조성물에 관한 것으로서, 더욱 상세하게는 위령선, 천화분 및 하고초를 적정비로 혼합하여 추출 정제함으로써 단방 추출한 것에 비하여 진통효과, 급성 및 만성염증 억제작용, 혈소판 응집 억제작용, 전혈응고 억제작용, 면역세포(B-임파구, T-임파구) 증식억제작용, 염증유발관련 효소(5-Lipoxygenase, Cyclooxygenase-1, Cyclooxygenase-Ⅱ)활성억제작용 및 유해활성산소라디칼(Superoxide radical)소거작용 등이 보다 우수한 유효성분을 효율적으로 추출·정제하는 방법과 그 추출물을 함우하는 소염진통제, 류마티스 관절염 치료제 및 혈액순환개선제 등의 생약 조성물에 관한 것이다.The present invention relates to a method for extracting and refining an active ingredient from an herbal medicine and a herbal composition containing the extract. More specifically, the analgesic effect is obtained by extracting and purifying the gastric gland, cheonhwa powder and vinegar in an appropriate ratio. , Acute and chronic inflammation inhibitory effect, platelet aggregation inhibitory effect, whole blood clotting inhibitory effect, immune cell (B-lymphocyte, T-lymphocyte) proliferation inhibitory effect, inflammation-related enzymes (5-Lipoxygenase, Cyclooxygenase-1, Cyclooxygenase-Ⅱ) A method for efficiently extracting and purifying an active ingredient having an active inhibitory action and a superoxide radical scavenging action, and a herbal composition including anti-inflammatory analgesics, rheumatoid arthritis treatment agents and blood circulation improving agents containing the extracts will be.

Description

복방 생약제로부터 유효활성 성분의 추출·정제방법과 그추출물을 함유한 생약 조성물Extraction and purification methods of active ingredients from herbal herbal medicines and herbal compositions containing the extracts

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (12)

위령선, 천화분 및 하고초의 혼합 생약으로부터의 추출물을 포함하는 복합 생약조성물.A composite herbal composition comprising an extract from a mixed herbal medicine of the gastric ginseng, cheonhwabun and hyacinth. 제1항에 있어서, 상기 혼합생약은 위령선, 천화분 및 하고초가 1:0.5~2:0.5~1.5의 중량비로 혼합된 것임을 특징으로 하는 복합 생약조성물.The compound herbal composition according to claim 1, wherein the mixed herbal medicine is a mixture of the gastrointestinal tract, cheonhwabun and hyacinth in a weight ratio of 1: 0.5-2: 0.5-1.5. 제1항에 있어서, 상기 추출물은 로스마리닌산과 올레아놀린산이 함유되어 있는 것을 특징으로 하는 복합 생약 조성물.The compound herbal composition according to claim 1, wherein the extract contains losmarinic acid and oleanolinic acid. 제3항에 있어서, 상기 로스마리닌산은 전체 추출물에 대해 0.3~0.6중량%로 함유되어 있는 것을 특징으로 하는 복합 생약 조성물.The complex herbal composition according to claim 3, wherein the losmarinic acid is contained in an amount of 0.3 to 0.6% by weight based on the total extract. 제3항에 있어서, 상기 올레아놀린산은 전체 추출물에 대해 3.0~7.0중량%로 함유되어 있는 것을 특징으로 하는 복합 생약조성물.The compound herbal composition according to claim 3, wherein the oleanolinic acid is contained in an amount of 3.0 to 7.0% by weight based on the total extract. 생약을 물 또는 알콜성 수용액으로 추출하여서 생약제를 제조함에 있어서, (1)위령선, 천화분 및 하고초의 생약을 1:0.5~2:0.5~1.5의 중량비로 혼합하고, 이 혼합생약을 물 또는 알콜성 수용액으로 추출하는 단계와, (2) 상기 추출단계에서 얻어진 여액을 동량의 수포화 n-부틸알콜 또는 수포화 프로필알콜로 층분리하여 알콜층을 감압 농축하는 단계와, (3) 상기 농축단계에서 얻어진 엑기스를 물로 공비농축하고 동결건조하여 분말엑기스를 제조하는 단계로 이루어진 것을 특징으로 하는 복합생약제의 제조방법.In the preparation of the herbal medicine by extracting the herbal medicine with water or alcoholic aqueous solution, (1) the herbal medicines of the gastrointestinal tract, hwahwabun and hydrangea are mixed in a weight ratio of 1: 0.5-2: 0.5-1.5, and the mixed herbal medicine is mixed with water or alcoholic Extracting with an aqueous solution, (2) separating the filtrate obtained in the extraction step into an equivalent amount of saturated n-butyl alcohol or saturated propyl alcohol, and concentrating the alcohol layer under reduced pressure; and (3) in the concentration step Method for producing a complex herbal medicine comprising the step of azeotropically concentrating the obtained extract with water and lyophilizing to prepare a powder extract. 제6항에 있어서, 상기 추출단게는 호합생약을 그 중량의10~15배의 물 또는 알콜성 수용액을 환류 추출하고 여과한 다음, 얻어진 잔사는 혼합생약 중량의 7~12배의 물 또는 알콜성 수용액 가하여 가온여과하고, 여기에 상기 환류 추출여액을 사형 다시 여과하는 방법으로 시행됨을 특징으로 하는 복합 생약제의 제조방법.According to claim 6, wherein the extraction step is a mixture of refrigeration of 10 to 15 times the weight of water or alcoholic aqueous solution and filtered, and then the residue obtained is 7 to 12 times the weight of the mixed herbal water or alcoholic Method of producing a complex herbal medicine, characterized in that carried out by the addition of an aqueous solution and warm filtration, and the recirculation extraction filtrate is carried out by re-filtration. 제6항에 있어서, 상기 감압농축은 60~70℃에서 시행됨을 특지으로 하는 복합생약제의 제조방법.The method of claim 6, wherein the reduced pressure concentration is carried out at 60 ~ 70 ℃ the manufacturing method of the complex herbal medicine. 제6항에 있어서, 상기 공비농툭은 엑기스 총량의 50~100배의 물로 2~3회 시행하는 것을 특징으로 하는 복합생약제의 제조방법.The method of claim 6, wherein the azeotropin is performed 2 to 3 times with water of 50 to 100 times the total amount of extract. 제1항의 추출물에 대한 분말엑기스를 유효성분으로 함유하는 소염진통제.Anti-inflammatory analgesic containing a powder extract of the extract of claim 1 as an active ingredient. 제1항의 추출물에 대한 분말 엑기스를 유효성분으로 함유하는 만성류마티스 관절염 치료제.A therapeutic agent for chronic rheumatoid arthritis containing a powder extract of the extract of claim 1 as an active ingredient. 제1항의 추출물에 대한 분말 엑기스를 유효성분으로 함유하는 혈액순환개선제.A blood circulation improving agent comprising a powder extract of the extract of claim 1 as an active ingredient. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019960043017A 1995-12-29 1996-09-30 Method for extracting and purifying effective reactive from compound crude drug KR0180567B1 (en)

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KR95-66619 1995-12-29
KR1019950066619A KR960033466A (en) 1995-03-31 1995-12-29 Extraction and Purification of Active Active Ingredients from Bok Fu Herbal Medicines and Herbal Medicine Compositions Containing the Extracts
KR1019960043017A KR0180567B1 (en) 1995-12-29 1996-09-30 Method for extracting and purifying effective reactive from compound crude drug

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100858733B1 (en) * 2002-04-22 2008-09-17 에스케이케미칼주식회사 Cartilage protective ingredients from Trichosanthes kirilowii

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010000815A (en) * 2000-10-20 2001-01-05 윤용길 Plaster for treatment of nervous paralysis
KR100483707B1 (en) * 2001-05-18 2005-04-18 에스케이케미칼주식회사 Cartilage protective ingredients from medicinal plants and their composition
KR20030082763A (en) * 2002-04-18 2003-10-23 에스케이케미칼주식회사 Articulation protective ingredients from medicinal plant and their composition
WO2014133329A1 (en) * 2013-02-27 2014-09-04 에스케이케미칼 주식회사 Composite formulation for treating arthritis
KR101974338B1 (en) * 2016-07-21 2019-05-02 서울대학교산학협력단 Hypoallergenic Cosmetic composition comprising the extract of Clematis apiifolia DC. or Silene armeria L. for alleviating skin inflammation
CN116744908A (en) 2020-11-24 2023-09-12 Sk化学公司 Pharmaceutical composition comprising high levels of active principles of natural origin
WO2022114796A1 (en) 2020-11-24 2022-06-02 에스케이케미칼 주식회사 Pharmaceutical composition comprising high content of active ingredients derived from natural substances

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100858733B1 (en) * 2002-04-22 2008-09-17 에스케이케미칼주식회사 Cartilage protective ingredients from Trichosanthes kirilowii

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