KR970010882A - A composition for forming an ion selective membrane provided on an electrode of a calcium ion sensor and a method of forming an ion selective membrane using the same - Google Patents

A composition for forming an ion selective membrane provided on an electrode of a calcium ion sensor and a method of forming an ion selective membrane using the same Download PDF

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KR970010882A
KR970010882A KR1019950026776A KR19950026776A KR970010882A KR 970010882 A KR970010882 A KR 970010882A KR 1019950026776 A KR1019950026776 A KR 1019950026776A KR 19950026776 A KR19950026776 A KR 19950026776A KR 970010882 A KR970010882 A KR 970010882A
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차근식
남학현
오봉균
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차근식
김동진
주식회사 카스
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    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
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Abstract

본 발명은 칼슘이온 센서의 전극에 구비되는 칼슘이온 선택성 막을 형성하기 위한 조성물 및 이것을 사용하여 칼슘이온 선택성 막을 형성하는 방법에 관한 것이다. 본 발명의 조성물은 단성분 실온경화형 실리콘러버 47.5∼87.1중량%, 가소제 11∼50중량%, 이온선택성 물질 0.5∼1.5중량% 및 친유성 첨가제 0.4∼2.0중량%로 이루어진다. 본 발명의 조성물을 사용하여 형성한 칼슘이온 선택성 막은 고체상 전극 표면에 구비되는 경우에는 그 표면과의 접착력이 우수하기 때문에 감응성의 감소가 방지되고, 수명이 연장되고, 전기화학적 성질이 우수하다. 따라서 칼슘이온 센서의 소형화를 더욱 더 촉진한다. 또한 본 발명의 조성물을 사용하여 형성한 칼슘이온 선택성 막은 고체상 전극 표면 또는 재래식 전극에 구비되어 사용되는 경우에는 혈액이나 뇨과 같은 생체 시료 또는 환경이나 수질중의 칼슘이온 농도 측정시 단백질 흡착으로 인한 비대칭 전위의 발생이 없을 뿐만 아니라 여러 가지 이온종에 의한 방해작용을 받지 않는다는 부가적인 효과가 있다.The present invention relates to a composition for forming a calcium ion selective membrane provided on an electrode of a calcium ion sensor and a method of forming a calcium ion selective membrane using the same. The composition of the present invention is composed of 47.5 to 87.1 wt% of a single component room temperature curing silicone rubber, 11 to 50 wt% of a plasticizer, 0.5 to 1.5 wt% of an ion-selective substance, and 0.4 to 2.0 wt% of a lipophilic additive. When the calcium ion selective film formed using the composition of this invention is provided in the surface of a solid-state electrode, since it is excellent in adhesive force with the surface, the reduction of a sensitivity is prevented, life is extended, and it is excellent in electrochemical property. Therefore, further miniaturization of the calcium ion sensor. In addition, when the calcium ion selective membrane formed by using the composition of the present invention is provided on the surface of a solid electrode or a conventional electrode, an asymmetric potential due to protein adsorption in a biological sample such as blood or urine or measurement of calcium ion concentration in the environment or water There is an additional effect that not only does not occur but is not disturbed by various ionic species.

Description

칼슘이온센서의 전극에 구비되는 이온 선택성 막을 형성하기 위한 조성물 및 이것을 사용하여 이온 선택성 막을 형성하는 방법A composition for forming an ion selective membrane provided on an electrode of a calcium ion sensor and a method of forming an ion selective membrane using the same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제1도는 일반적인 재래식 이온 선택성 막 전극과 고체상 이온 선택성 막 전극의 단면도로, (가)는 재래식 이온 선택성 막 전극이고, (나)는 고체상 이온 선택성 막 전극이며,1 is a cross-sectional view of a conventional conventional ion selective membrane electrode and a solid phase ion selective membrane electrode, (a) is a conventional ion selective membrane electrode, (b) is a solid phase ion selective membrane electrode,

제2도는 이온 선택성 물질로, N,N,N′,N′-테트라시클로헥실-3-옥사펜탄디아미드를 사용하여 PVC-지지체(■), 가소제가 첨가되지 않은 실리콘 러버(SR)-지지체(▲), 가소제가 첨가된 SR-지지체(◆) 그리고 가소제와 친유성 첨가제가 첨가된 SR-지지체(●) 칼슘이온 선택성 막을 재래식 형태의 전극에 장착하여 감응성 테스트 하였을 때의 감응특성을 나타낸 그래프이고,Figure 2 is an ion-selective material, a silicone rubber (SR) -support without N, N, N ', N'-tetracyclohexyl-3-oxapentanediamide, with no PVC-support or plasticizer added. (▲), SR-support with plasticizer (◆) and SR-support (●) calcium ion-selective membrane with plasticizer and lipophilic additive were attached to conventional electrodes for sensitivity test. ego,

제3도는 이온 선택성 물질로(-)-(R,R)-N,N′-[비스(11-에톡시카르보닐)운데실]-N,N′,4,5-테트라메틸-3,6-디옥사옥탄디아미드를 사용하여 PVC-지지체(■), 가소제가 첨가되지 않은 SR-지지체(▲), 가소제가 첨가된 SR-지지체(◆), 그리고 가소제와 친유성 첨가제가 첨가된 SR-지지체(●), 칼슘이온 선택성 막을 재래식 형태의 전극에 장착하여 감응성 테스트 하였을 때의 감응특성을 나타낸 그래프이고,3 shows ion-selective materials (-)-(R, R) -N, N '-[bis (11-ethoxycarbonyl) undecyl] -N, N', 4,5-tetramethyl-3, PVC-support (■) with 6-dioxaoctanediamide, SR-support without plasticizer (▲), SR-support with plasticizer (◆), and SR with plasticizer and lipophilic additive -It is a graph showing the response characteristics when the support (●) and calcium ion selective membranes were mounted on the conventional electrode and subjected to the sensitivity test.

제4도는 N,N,N′,N′-테트라시클로헥실-3-옥사펜탄디아미드를 이온 선택성 물질로 하고 고체상 전극에 PVC-지지체 막과 가소제와 친유성 첨가제가 첨가된 실리콘 러버-지지체 막의 칼슘이온(ㄱ)과 나트륨이온(ㄴ)에 대한 감응성을 나타낸 것으로, (가)는 PVC-지지체 막의 감응성 그래프이며, (나)는 가소제와 친유성 첨가제가 첨가된 실리콘 러버-지지체 막의 감응성 그래프이고,4 shows a silicone rubber-support membrane in which N, N, N ', N'-tetracyclohexyl-3-oxapentanediamide is an ion-selective material and a PVC-support membrane, a plasticizer and a lipophilic additive are added to a solid-state electrode. Sensitivity to calcium ions (a) and sodium ions (b), (A) is a graph of the sensitivity of the PVC-support membrane, (B) is a graph of the sensitivity of the silicone rubber-support membrane added with a plasticizer and a lipophilic additive ,

제5도는 (-)-(R,R)-N,N′-[비스(11-에톡시카르보닐)운데실]-N,N′,4,5-테트라메틸-3,6-디옥사옥탄디아미드를 이온 선택성 물질로 하고, 고체상 전극에 PVC-지지체 막과 가소제와 친유성 첨가제가 실리콘 러버-지지체 막의 칼슘이온(ㄱ)과 나트륨이온(ㄴ)에 대한 감응성을 나타낸 것으로, (가)는 PVC-지지체막의 감응성 그래프이며, (나)는 가소제와 친유성 첨가제가 첨가된 실리콘 러버-지지체 막의 감응성 그래프이고,5 shows (-)-(R, R) -N, N '-[bis (11-ethoxycarbonyl) undecyl] -N, N', 4,5-tetramethyl-3,6-dioxa Octanediamide is an ion-selective material, and the PVC-supported membrane, plasticizer and lipophilic additive on the solid-state electrode showed sensitivity to calcium ions (a) and sodium ions (b) of the silicone rubber-supported membrane. Is a graph of the sensitivity of the PVC-supported membrane, (b) is a graph of the sensitivity of the silicone rubber-supported membrane added with a plasticizer and a lipophilic additive

제6도는 수용액 상에서 11일이 경과한 후 고체상 전극에서 가소제와 친유성 첨가제가 첨가된 실리콘 러버-지지체 막(ㄱ)과 PVC-지지체 막(ㄴ)의 칼슘이온에 대한 감응성을 나타낸 그래프이다.6 is a graph showing the sensitivity to calcium ions of the silicone rubber-supporting membrane (a) and the PVC-supporting membrane (b) to which the plasticizer and the lipophilic additive were added in the solid-state electrode after 11 days in the aqueous solution.

Claims (12)

단성분 실온경화형 실리콘러버 47.5∼87.1중량%, 가소제 11∼50중량%, 이온선택성 물질 0.5∼1.5중량% 및 친유성 첨가제 0.4∼2.0중량%로 이루어진 것을 특징으로 하는 칼슘이온 센서의 고체상 전극 표면상에 이온 선택성 막을 형성하기 위한 조성물.On the solid-state electrode surface of the calcium ion sensor, which is composed of 47.5 to 88.1% by weight of a single component room temperature-curable silicone rubber, 11 to 50% by weight of a plasticizer, 0.5 to 1.5% by weight of an ion-selective material, and 0.4 to 2.0% by weight of a lipophilic additive. A composition for forming an ion selective membrane in a film. 제1항에 있어서, 가소제는 비스(2-에틸헥실)아디페이트, 비스(2-에틸헥실)세바케이트 및 2-니트로페닐 옥틸 에테르로 이루어진 그룹에서 선택되는 것을 특징으로 하는 조성물.The composition of claim 1 wherein the plasticizer is selected from the group consisting of bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) sebacate and 2-nitrophenyl octyl ether. 제1항에 있어서, 이온 선택성 물질은 N,N,N′,N′-테트라시클로헥실-3-옥사펜탄디아미드; (-)-(R,R)-N,N′-[비스(11-에톡시카르보닐)운데실]-N,N′,4,5-테트라메틸-3,6-디옥사옥탄디아미드; 및 N,N-디시클로헥실-N′,N′-디옥타데실-3-옥사펜탄디아미드로 이루어진 그룹에서 선택되는 것을 특징으로 하는 조성물.The method of claim 1, wherein the ion selective material is selected from the group consisting of N, N, N ′, N′-tetracyclohexyl-3-oxapentanediamide; (-)-(R, R) -N, N '-[bis (11-ethoxycarbonyl) undecyl] -N, N', 4,5-tetramethyl-3,6-dioxaoctanediamide ; And N, N-dicyclohexyl-N ', N'-dioctadecyl-3-oxapentanediamide. 제1항에 있어서, 친유성 첨가제는 테트라도데실암모늄 테트라키스(4-클로로페닐)보레이트; 테트라키스(4-클로로페닐)보론 포타슘; 및 이들의 혼합물로 이루어진 그룹에서 선택되는 것을 특징으로 하는 조성물.The method of claim 1, wherein the lipophilic additive comprises tetradodecylammonium tetrakis (4-chlorophenyl) borate; Tetrakis (4-chlorophenyl) boron potassium; And mixtures thereof. 제1항에 있어서, 칼슘이온 센서는 생체 시료, 환경 및 수질중의 칼슘이온 농도를 측정하기 위해 사용되는 것을 특징으로 하는 조성물.The composition of claim 1, wherein the calcium ion sensor is used to measure calcium ion concentrations in biological samples, the environment, and water. 단성분 실온경화형 실리콘러버 47.5∼87.1중량%, 가소제 11∼50중량%, 이온선택성 물질 0.5∼1.5중량% 및 친유성 첨가제 0.4∼2.0중량%로 이루어진 것을 특징으로 하는 칼슘이온 센서의 재래식 전극에 구비되는 이온 선택성 막을 제조하기 위한 조성물.It is provided in a conventional electrode of a calcium ion sensor comprising 47.5 to 88.1% by weight of a single component room temperature-curable silicone rubber, 11 to 50% by weight of a plasticizer, 0.5 to 1.5% by weight of an ion-selective material, and 0.4 to 2.0% by weight of a lipophilic additive. A composition for producing an ion selective membrane. 제6항에 있어서, 가소제는 비스(2-에틸헥실)아디페이트, 비스(2-에틸헥실)세바케이트 및 2-니트로페닐 옥틸 에테르로 이루어진 그룹에서 선택되는 것을 특징으로 하는 조성물.7. The composition of claim 6 wherein the plasticizer is selected from the group consisting of bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) sebacate and 2-nitrophenyl octyl ether. 제6항에 있어서, 이온 선택성 물질은 N,N,N′,N′-테트라시클로헥실-3-옥사펜탄디아미드; (-)-(R,R)-N,N′-[비스(11-에톡시카르보닐)운데실]-N,N′,4,5-테트라메틸-3,6-디옥사옥탄디아미드; 및 N,N-디시클로헥실-N′,N′-디옥타데실-3-옥사펜탄디아미드로 이루어진 그룹에서 선택되는 것을 특징으로 하는 조성물.The method of claim 6, wherein the ion selective material is selected from the group consisting of N, N, N ′, N′-tetracyclohexyl-3-oxapentanediamide; (-)-(R, R) -N, N '-[bis (11-ethoxycarbonyl) undecyl] -N, N', 4,5-tetramethyl-3,6-dioxaoctanediamide ; And N, N-dicyclohexyl-N ', N'-dioctadecyl-3-oxapentanediamide. 제6항에 있어서, 친유성 첨가제는 테트라도데실암모늄 테트라키스(4-클로로페닐)보레이트; 테트라키스(4-클로로페닐)보론 포타슘; 및 이들의 혼합물로 이루어진 그룹에서 선택되는 것을 특징으로 하는 조성물.The method of claim 6, wherein the lipophilic additive comprises tetradodecylammonium tetrakis (4-chlorophenyl) borate; Tetrakis (4-chlorophenyl) boron potassium; And mixtures thereof. 제6항에 있어서, 칼슘이온 센서는 생체 시료, 환경 및 수질중의 칼슘이온 농도를 측정하기 위해 사용되는 것을 특징으로 하는 조성물.The composition of claim 6, wherein the calcium ion sensor is used to measure calcium ion concentrations in biological samples, the environment and water. 칼슘이온 센서의 고체상 전극 표면상에 이온 선택성 막을 형성하는 방법에 있어서, 단성분 실온경화형 실리콘 러버 47.5∼87.1중량%, 가소제 11∼50중량%, 이온선택성 물질 0.5∼1.5중량% 및 친유성 첨가제 0.4∼2.0중량%로 이루어진 조성물을 유기용매에 녹인 후 전극 표면상에 코팅하는 공정을 포함하는 것을 특징으로 하는 방법.In the method of forming an ion-selective membrane on the surface of a solid-state electrode of a calcium ion sensor, 47.5 to 88.1% by weight of a single component room temperature-curable silicone rubber, 11 to 50% by weight of a plasticizer, 0.5 to 1.5% by weight of an ion-selective material, and a lipophilic additive 0.4 And dissolving the composition consisting of -2.0% by weight in an organic solvent and then coating it on the electrode surface. 칼슘이온 센서의 재래식 전극에 구비되는 이온 선택성 막을 제조하기 위한 방법에 있어서, 단성분 실온경화형 실리콘 러버 47.5∼87.1중량%, 가소제 11∼50중량%, 이온선택성 물질 0.5∼1.5중량% 및 친유성 첨가제 0.4∼2.0중량%로 이루어진 조성물을 유기용매에 녹여서 용액을 형성하는 공정 및 상기의 용액을 유리판 또는 테프론판 위의 유리링에 부어 건조시킨 후 성형하는 공정을 포함하는 것을 특징으로 하는 방법.In the method for producing an ion-selective membrane provided in the conventional electrode of the calcium ion sensor, 47.5 to 88.1% by weight of single-component room temperature curing silicone rubber, 11 to 50% by weight plasticizer, 0.5 to 1.5% by weight ion-selective material and lipophilic additive And a step of forming a solution by dissolving a composition of 0.4 to 2.0% by weight in an organic solvent, and pouring the solution into a glass ring on a glass plate or a teflon plate, followed by drying and molding. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
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KR20010019916A (en) * 1999-08-31 2001-03-15 추호석 High efficiency weaving SAW(Surmerged Arc Welding) process
KR101392666B1 (en) * 2013-01-16 2014-05-14 광운대학교 산학협력단 Composition for solid state ion-selective membrane electrodes and ion sensors manufactured from the same
KR20170132081A (en) 2016-05-23 2017-12-01 고려대학교 세종산학협력단 Immunological biosensor and sensor system including the same

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KR100518654B1 (en) * 2003-11-10 2005-10-05 (주)엘파워텍 Ion-selective membrane and fabrication method of the ion-selective membrane

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010019916A (en) * 1999-08-31 2001-03-15 추호석 High efficiency weaving SAW(Surmerged Arc Welding) process
KR101392666B1 (en) * 2013-01-16 2014-05-14 광운대학교 산학협력단 Composition for solid state ion-selective membrane electrodes and ion sensors manufactured from the same
KR20170132081A (en) 2016-05-23 2017-12-01 고려대학교 세종산학협력단 Immunological biosensor and sensor system including the same

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