KR970002307A - Solid ion sensor comprising a composition for forming an ion sensing membrane and an ion sensing membrane - Google Patents

Solid ion sensor comprising a composition for forming an ion sensing membrane and an ion sensing membrane Download PDF

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KR970002307A
KR970002307A KR1019950015308A KR19950015308A KR970002307A KR 970002307 A KR970002307 A KR 970002307A KR 1019950015308 A KR1019950015308 A KR 1019950015308A KR 19950015308 A KR19950015308 A KR 19950015308A KR 970002307 A KR970002307 A KR 970002307A
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ion
bis
plasticizer
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KR1019950015308A
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KR100204410B1 (en
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김철
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김동진
주식회사 카 스
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes
    • G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

본 발명은 고체형 이온 센서에 관한 것으로서, 특히 종래의 재래식 전극형 이온 센서의 감지막과 거의 대응한 이온 감지 특성을 지니면서도 금속 전극 표면에 대한 우수한 접착력을 지니는 이온 감지막을 구비하는 고체형 이온 센서에 관한 것이다. 본 발명의 고체형 이온 센서는 금속 전극과; 이것의 표면에 씌워져 있는 실리콘 고무 68.5~94.5중량%, 가소제 5~30중량% 및 이온 선택성 물질 0.5~1.5중량%의 조성물로 형성된 이온 감지막을 구비하는 것을 특징으로 한다. 또한, 본 발명은 고체형 이온 센서, 그리고 그 이온 센서와 동일 고체 기판 위에 형성되고 그 이온 센서와 전기적으로 결합된 트랜지스터 또는 전자 회로로 구성되는 고체형 집적화 이온 센서를 제공한다. 본 발명의 이온 센서는 임상검사를 위하여 혈액 또는 혈청 중의 나트륨, 칼륨, 칼슘 또는 염화이온 농도를 측정하는 의료기기로서 사용될 수 있다.BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a solid ion sensor, in particular a solid ion sensor having an ion sensing membrane having an ion sensing characteristic almost corresponding to that of a conventional conventional electrode type ion sensor and having excellent adhesion to a metal electrode surface. It is about. The solid ion sensor of the present invention comprises a metal electrode; And an ion sensing membrane formed of a composition of 68.5 to 99.5% by weight of silicone rubber, 5 to 30% by weight of a plasticizer and 0.5 to 1.5% by weight of an ion-selective material. The present invention also provides a solid state ion sensor and a solid state integrated ion sensor composed of a transistor or an electronic circuit formed on the same solid substrate as the ion sensor and electrically coupled with the ion sensor. The ion sensor of the present invention can be used as a medical device for measuring the concentration of sodium, potassium, calcium or chloride ion in blood or serum for clinical examination.

Description

이온 감지막을 형성하기 위한 조성물 및 이온 감지막을 구비하는 고체형 이온 센서Solid ion sensor comprising a composition for forming an ion sensing membrane and an ion sensing membrane

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제2도는 혈액속의 이온농도를 측정하기 위해 본 발명의 고체형 이온 센서를 구비하는 시스템의 블록도.2 is a block diagram of a system comprising a solid ion sensor of the present invention for measuring the concentration of ions in blood.

Claims (19)

탈알콜 및 탈초산형 실리콘 고무 68.5~94.5중량%, 가소제 5~30중량% 및 이온선택성 물질 0.5~1.5중량%로 이루어진 것을 특징으로 하는 고체형 이온 센서의 이온 감지막을 형성하기 위한 조성물.A composition for forming an ion-sensing membrane of a solid ion sensor, comprising 68.5 to 99.5% by weight of dealcohol and deacetic acid type silicone rubber, 5 to 30% by weight of a plasticizer, and 0.5 to 1.5% by weight of an ion selective material. 제1항에 있어서, 가소제가 알킬 아디페이트 또는 알킬 세바케이트인 것을 특징으로 하는 조성물.The composition of claim 1 wherein the plasticizer is an alkyl adipate or an alkyl sebacate. 제2항에 있어서, 가소제가 비스(2-에틸헥실)아디페이트, 비스-1(-부틸펜텔)아디페이트, 비스(2-이틸헥실)세바케이트 및 디부틸 세바케이트로 이루어진 그룹에서 선택되는 것을 특징으로 하는 조성물.3. The plasticizer of claim 2 wherein the plasticizer is selected from the group consisting of bis (2-ethylhexyl) adipate, bis-1 (-butylpentel) adipate, bis (2-ethylhexyl) sebacate and dibutyl sebacate Characterized in that the composition. 제1항에 있어서, 이온 선택성 물질이 나트륨 이온을 선택하기 위한 것으로서, N,N',N"-트리헵틸-N,N',N"-트리메틸-4,4',4"-프로필리딘트리스(3-옥사부틸아미드); N,N'-디벤질-N,N'-디페닐-1,2-페닐렌디옥시디아세트아미드; N,N,N',N'-테트라시클로헥실-1,2-페닐렌디옥시아세트아미드; 4-옥타데카노일옥시메틸-N,N,N',N'-테트라시클로헥실-1,2-페닐렌디옥시디아세트아미드; 및 비스[(12-크라운-4)메틸]도데실 메틸말론에이트로 이루어진 그룹에서 선택되는 것을 특징으로 하는 조성물.The method of claim 1, wherein the ion selective material is for selecting sodium ions, wherein N, N ', N "-triheptyl-N, N', N" -trimethyl-4,4 ', 4 "-propylidinetris (3-oxabutylamide); N, N'-dibenzyl-N, N'-diphenyl-1,2-phenylenedioxydiacetamide; N, N, N ', N'-tetracyclohexyl-1 , 2-phenylenedioxyacetamide; 4-octadecanoyloxymethyl-N, N, N ', N'-tetracyclohexyl-1,2-phenylenedioxydiacetamide; and bis [(12-crown- 4) methyl] dodecyl methylmalonate. 제1항에 있어서, 이온 선택성 물질이 칼륨 이온을 선택하기 위한 것으로서 발리노마이신인 것을 특징으로 하는 조성물.The composition of claim 1, wherein the ion selective material is ballinomycin for selecting potassium ions. 제1항에 있어서, 이온 선택성 물질이 칼슘이온을 선택하기 위한 것으로(-)-(R,R)-N,N'-[비스(11-에톡시카르보닐)운데실]-N,N'-4,5-테트라메틸-3,6-디옥탄디아미드;N,N,N'N'-테드라시클로헥실-3-옥사펜탄디아미드; 및 N,N'-디시클로헥실-N,N'-디옥타데실-3-옥사펜탄디아미드로 이루어진 그룹에서 선택되는 것을 특징으로 하는 조성물.The method of claim 1, wherein the ion-selective material is for selecting calcium ions (-)-(R, R) -N, N '-[bis (11-ethoxycarbonyl) undecyl] -N, N' -4,5-tetramethyl-3,6-dioctanediamide; N, N, N'N'-tetracyclohexyl-3-oxapentanediamide; And N, N'-dicyclohexyl-N, N'-dioctadecyl-3-oxapentanediamide. 제1항에 있어서, 이온 선택성 물질이 염화이온을 선택하기 위한 것으로서, 5,10,15,20-테트라펜틸-21H,23H-포르핀망간(Ⅲ)클로라이드인 것을 특징으로 하는 조성물.The composition of claim 1, wherein the ion selective material is 5,10,15,20-tetrapentyl-21H, 23H-phosphine manganese (III) chloride for selecting chloride ions. 금속 전극과; 탈알콜 및 탈초산형 실리콘 고무 68.5~94.5중량%, 가소제 5~30중량% 및 이온선택성 물질의 조성물로 이루어진 이온 감지막을 상기의 금속 전극상에서 구비하는 것을 특징으로 하는 고체형 이온 센서.A metal electrode; A solid ion sensor comprising an ion sensing membrane made of a composition of de-alcohol and deacetic acid type silicone rubber 68.5 to 99.5% by weight, a plasticizer of 5 to 30% by weight, and an ion-selective material on the metal electrode. 제8항에 있어서, 혈액 중의 나트륨, 칼륨, 칼슘 또는 염화이온 농도를 측정하기 위해 사용되는 것을 특징으로 하는 고체형 이온 센서.9. A solid ion sensor according to claim 8, which is used for measuring sodium, potassium, calcium or chloride ion concentration in blood. 제8항에 있어서, 가소제가 비스(2-에틸헥실)아디페이트, 비스-1(-부틸펜텔)아디페이트, 비스(20-에틸헥실)세바케이트 및 디부틸 세바케이트로 이루어진 그룹에서 선택되는 것을 특징으로 하는 고체형 이온 센서.9. The plasticizer of claim 8 wherein the plasticizer is selected from the group consisting of bis (2-ethylhexyl) adipate, bis-1 (-butylpentel) adipate, bis (20-ethylhexyl) sebacate and dibutyl sebacate. Solid ion sensor characterized in that. 금속 전극과; 상기 금속 전극의 작동 부위에 접착되도록 배열된, 탈알콜 및 탈초산형 실리콘 고무 68.5~94.5중량%, 가소제 5~30중량% 및 이온선택성 물질 0.5~1.5중량%의 조성물로 이루어진 이온 감지막과; 상기 금속 전극의 작동 부위를 제외한 부분의 피측정 용액과 전기적으로 절연될 수 있도록 배열된 절연막으로 이루어진 것을 특징으로 하는 고체형 이온 센서.A metal electrode; An ion sensing membrane composed of a composition of dealcohol and deacetic acid-type silicone rubber 68.5 to 99.5% by weight, plasticizer 5 to 30% by weight, and 0.5 to 1.5% by weight of an ion-selective material, arranged to adhere to the working site of the metal electrode; And an insulating film arranged to be electrically insulated from the solution under test except for the operation portion of the metal electrode. 제11항에 있어서, 혈액 중의 나트륨, 칼륨, 칼슘 또는 염화이온 농도를 측정하기 위해 사용되는 것을 특징으로 하는 고체형 이온 센서.12. The solid ion sensor according to claim 11, which is used to measure sodium, potassium, calcium or chloride ion concentration in blood. 제11항에 있어서, 가소제가 비스(2-에틸헥실)아디페이트, 비스-(1-부틸펜텔)아디페이트, 비스(2-에텔헥실)세바케이트 및 디부틸 세바케이트로 이루어진 그룹에서 선택되는 것을 특징으로 하는 고체형 이온 센서.12. The plasticizer of claim 11 wherein the plasticizer is selected from the group consisting of bis (2-ethylhexyl) adipate, bis- (1-butylpentel) adipate, bis (2-etherhexyl) sebacate and dibutyl sebacate Solid ion sensor characterized in that. 절연성 지지부재(electrically insulating suppot member)와; 상기 절연성 지지부재에 의해 지지되는 금속 전극과; 상기 금속 전극의 일부분을 접착상태로 둘러싸는 탈알콜 및 탈초산형 실리콘 고무 68.5~94.5중량%, 가소제 5~30중량% 및 이온선택성 물질 0.5~1.5중량%의 조성물로 이루어진 이온 감지막과; 상기 금속 전극의 타부분을 피측정 용액과 분리시키기 위하여 상기 금속 전극의 타부분에 피복되어 있는 절연막으로 이루어진 것을 특징으로 하는 고체형 이온 센서.An electrically insulating suppot member; A metal electrode supported by the insulating support member; An ion sensing membrane comprising a composition of a dealcohol and a denitrification type silicone rubber 68.5 to 99.5% by weight, a plasticizer 5 to 30% by weight, and an ion selective material 0.5 to 1.5% by weight to surround a portion of the metal electrode in an adhesive state; And an insulating film coated on the other part of the metal electrode to separate the other part of the metal electrode from the solution to be measured. 제14항에 있어서, 혈액 중의 나트륨, 칼륨, 칼슘 및/또는 염화이온 농도를 측정하기 위해 사용되는 것을 특징으로 하는 고체형 이온 센서.15. The solid ion sensor according to claim 14, which is used for measuring sodium, potassium, calcium and / or chloride ion concentration in blood. 제14항에 있어서, 가소제가 비스(2-에틸헥실)아디페이트, 비스(1-부틸펜틸)아디페이트, 비스(2-에틸헥실)세바케이트 및 디부틸 세바케이트로 이루어진 그룹에서 선택되는 것을 특징으로 하는 고체형 이온 센서.The plasticizer of claim 14 wherein the plasticizer is selected from the group consisting of bis (2-ethylhexyl) adipate, bis (1-butylpentyl) adipate, bis (2-ethylhexyl) sebacate and dibutyl sebacate. Solid ion sensor. 이온 감지 전계 효과 트랜지스터(ISFET)로 이루어진 전극과; 상기 이온 감지 전계 효과 트랜지스터의 게이트 절연막 표면에 접착되도록 배열된 것으로서, 탈알콜 및 탈초산형 실리콘 고무 68.5~94.5중량%, 가소제 5~30중량% 및 이온선택성 물질 0.5~1.5중량%의 조성물로 이루어진 이온 감지막으로 구성되는 것을 특징으로 하는 고체형 이온 센서.An electrode composed of an ion sensing field effect transistor (ISFET); It is arranged to adhere to the surface of the gate insulating film of the ion-sensing field effect transistor, the ion consisting of the composition of the de-alcohol and deacetic acid silicone rubber 68.5 ~ 99.5% by weight, the plasticizer 5-30% by weight and the ion-selective material 0.5-1.5% by weight Solid ion sensor, characterized in that consisting of a sensing film. 제17항에 있어서, 혈액 중의 나트륨, 칼륨, 칼슘 및/또는 염화이온 농도를 측정하기 위해 사용되는 것을 특징으로 하는 고체형 이온 센서.18. The solid ion sensor of claim 17, wherein the solid ion sensor is used to measure sodium, potassium, calcium and / or chloride ion concentrations in the blood. 제17항에 있어서, 가소제가 비스(2-에틸헥실)아디페이트, 비스(1-부틸펜틸)아디페이트, 비스(2-에틸헥실)세바케이트 및 디부틸 세바케이트로 이루어진 그룹에서 선택되는 것을 특징으로 하는 고체형 이온 센서.18. The plasticizer of claim 17 wherein the plasticizer is selected from the group consisting of bis (2-ethylhexyl) adipate, bis (1-butylpentyl) adipate, bis (2-ethylhexyl) sebacate and dibutyl sebacate. Solid ion sensor. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950015308A 1995-06-10 1995-06-10 Composite for forming sensing membrane and solid ion sensor made of it KR100204410B1 (en)

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