KR960703597A - 아폽토시스 및 관련 상태의 치료방법(methods of treating apoptosis and associated conditions) - Google Patents
아폽토시스 및 관련 상태의 치료방법(methods of treating apoptosis and associated conditions) Download PDFInfo
- Publication number
- KR960703597A KR960703597A KR1019960700340A KR19960700340A KR960703597A KR 960703597 A KR960703597 A KR 960703597A KR 1019960700340 A KR1019960700340 A KR 1019960700340A KR 19960700340 A KR19960700340 A KR 19960700340A KR 960703597 A KR960703597 A KR 960703597A
- Authority
- KR
- South Korea
- Prior art keywords
- dioxopiperazine
- bis
- apoptosis
- apoptotic
- trend
- Prior art date
Links
- 230000006907 apoptotic process Effects 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title claims abstract 18
- JTHRRMFZHSDGNJ-UHFFFAOYSA-N piperazine-2,3-dione Chemical compound O=C1NCCNC1=O JTHRRMFZHSDGNJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 208000010125 myocardial infarction Diseases 0.000 claims 5
- 230000001640 apoptogenic effect Effects 0.000 claims 3
- 230000001575 pathological effect Effects 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 2
- 208000007502 anemia Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- CYJAWBVQRMVFEO-UHFFFAOYSA-N piperazine-2,6-dione Chemical compound O=C1CNCC(=O)N1 CYJAWBVQRMVFEO-UHFFFAOYSA-N 0.000 claims 2
- 208000001778 Coronary Occlusion Diseases 0.000 claims 1
- 206010011086 Coronary artery occlusion Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000020339 Spinal injury Diseases 0.000 claims 1
- 206010000891 acute myocardial infarction Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000001848 dysentery Diseases 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 230000003589 nefrotoxic effect Effects 0.000 claims 1
- 231100000381 nephrotoxic Toxicity 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9678893A | 1993-07-23 | 1993-07-23 | |
| US08/096,788 | 1993-07-23 | ||
| PCT/US1994/008268 WO1995003054A1 (en) | 1993-07-23 | 1994-07-22 | Methods of treating apoptosis and associated conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR960703597A true KR960703597A (ko) | 1996-08-31 |
Family
ID=22259083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019960700340A KR960703597A (ko) | 1993-07-23 | 1994-07-22 | 아폽토시스 및 관련 상태의 치료방법(methods of treating apoptosis and associated conditions) |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0711168A4 (pt) |
| JP (1) | JPH09503749A (pt) |
| KR (1) | KR960703597A (pt) |
| AU (1) | AU7370594A (pt) |
| BR (1) | BR9407145A (pt) |
| CA (1) | CA2167805A1 (pt) |
| WO (1) | WO1995003054A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3866800B2 (ja) * | 1996-08-29 | 2007-01-10 | 東菱薬品工業株式会社 | アポトーシス関連疾患の予防及び／又は治療薬 |
| HUP0202791A3 (en) * | 1999-09-10 | 2003-02-28 | Cyathus Exquirere Pharmaforsch | Pharmaceutical compositions for treating psoriasis |
| US6693100B1 (en) | 1999-09-10 | 2004-02-17 | Iervant Zarmanian | Pharmaceutical compositions for treating psoriasis |
| AU5150200A (en) * | 1999-11-24 | 2001-06-04 | Emory University | Diimino-piperazine derivatives for use as modulators of cell regulation |
| US6552025B1 (en) | 1999-11-24 | 2003-04-22 | Emory University | Diimino-piperazine derivatives for use as modulators of cell regulation |
| JP5048201B2 (ja) | 2000-08-04 | 2012-10-17 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | ジケトピペラジン類の使用方法とジケトピペラジン類を含む組成物 |
| EP2517721A3 (en) * | 2003-05-15 | 2013-04-10 | DMI Biosciences, Inc. | Treatment of T-cell mediated diseases |
| US7838562B2 (en) * | 2003-06-24 | 2010-11-23 | University Of Connecticut | Methods of inhibiting vascular permeability and apoptosis |
| GB0314733D0 (en) * | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Medicaments |
| WO2008021250A2 (en) * | 2006-08-10 | 2008-02-21 | Fred Hutchinson Cancer Research Center | Compositions and methods for modulating apoptosis in cells over-expressing bcl-2 family member proteins |
| US8217047B2 (en) | 2008-05-27 | 2012-07-10 | Dmi Acquisition Corp. | Therapeutic methods and compounds |
| EP2613786A4 (en) | 2010-09-07 | 2013-10-23 | Dmi Acquisition Corp | TREATMENT OF DISEASES |
| EP3721884A1 (en) | 2011-10-10 | 2020-10-14 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease with da-dkp (= aspartyl-alanyl diketopiperazine) |
| MX2014003856A (es) | 2011-10-10 | 2015-01-16 | Ampio Pharmaceuticals Inc | Dispositivos medicos implantables con tolerancia inmune incrementada y metodos para hacerlos e implantarlos. |
| EP2771007B1 (en) | 2011-10-28 | 2018-04-04 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
| US9808454B2 (en) | 2013-03-15 | 2017-11-07 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
| KR20170045274A (ko) | 2014-08-18 | 2017-04-26 | 앰피오 파마슈티컬스 인코퍼레이티드 | 관절 징후의 치료 |
| WO2016209969A1 (en) | 2015-06-22 | 2016-12-29 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8916072D0 (en) * | 1989-07-13 | 1989-08-31 | Creighton Andrew M | Pharmaceutical compositions |
| GB9024861D0 (en) * | 1990-11-15 | 1991-01-02 | Hellmann Kurt | Bis-dioxopiperazines for treating liver tumors |
-
1994
- 1994-07-22 CA CA002167805A patent/CA2167805A1/en not_active Abandoned
- 1994-07-22 BR BR9407145A patent/BR9407145A/pt not_active Application Discontinuation
- 1994-07-22 WO PCT/US1994/008268 patent/WO1995003054A1/en not_active Application Discontinuation
- 1994-07-22 EP EP94922680A patent/EP0711168A4/en not_active Withdrawn
- 1994-07-22 AU AU73705/94A patent/AU7370594A/en not_active Abandoned
- 1994-07-22 KR KR1019960700340A patent/KR960703597A/ko not_active Application Discontinuation
- 1994-07-22 JP JP7505327A patent/JPH09503749A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR9407145A (pt) | 1996-09-17 |
| EP0711168A4 (en) | 1998-04-01 |
| CA2167805A1 (en) | 1995-02-02 |
| WO1995003054A1 (en) | 1995-02-02 |
| JPH09503749A (ja) | 1997-04-15 |
| AU7370594A (en) | 1995-02-20 |
| EP0711168A1 (en) | 1996-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |