KR960034413A - 아폽토시스 조절 유전자 - Google Patents

아폽토시스 조절 유전자 Download PDF

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Publication number
KR960034413A
KR960034413A KR1019950006266A KR19950006266A KR960034413A KR 960034413 A KR960034413 A KR 960034413A KR 1019950006266 A KR1019950006266 A KR 1019950006266A KR 19950006266 A KR19950006266 A KR 19950006266A KR 960034413 A KR960034413 A KR 960034413A
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South Korea
Prior art keywords
apoptosis
clone
development
apoptosis regulatory
regulatory genes
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KR1019950006266A
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English (en)
Inventor
신희섭
성영철
최선심
윤진원
최은경
Original Assignee
권계홍
주식회사 녹십자
김만제
학교법인 제철학원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 권계홍, 주식회사 녹십자, 김만제, 학교법인 제철학원 filed Critical 권계홍
Priority to KR1019950006266A priority Critical patent/KR960034413A/ko
Priority to EP96907773A priority patent/EP0759075B1/en
Priority to DE69634939T priority patent/DE69634939D1/de
Priority to PCT/KR1996/000040 priority patent/WO1996030513A1/en
Priority to JP8529196A priority patent/JPH10504975A/ja
Priority to KR1019960008132A priority patent/KR100302057B1/ko
Priority to US08/737,980 priority patent/US5843773A/en
Priority to CA002191214A priority patent/CA2191214A1/en
Publication of KR960034413A publication Critical patent/KR960034413A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 아폽토시스 불록커라 알려진 bcl-2와 동종성을 갖는 신규한 아폽토시스 조절 유전자에 관한 것으로서 인간의 태아 간 조직으로부터 분리하여 fl-383d 클론으로 명명하였다. fl-383d는 총 734bp의 염기로 이루어졌으며, 한개의 오픈리딩 프레임을 가지고 있고, fl-383d 클론으로 형질전환된 383-E.coli는 한국종균협회에 KKCCM10061호로 기탁되어 있다. 아폽토시스의 분자적 기작이 거의 연구되지 않은 상황에서 아폽토시스 조절에 관하여 새로운 유전자의 발견은 아폽토시스 기작의 이해 및 이를 응용한 암의 진단시약, 암치료제의 개발 등에 유용하게 이용할 수 있다.

Description

아폽토시스 조절 유전자
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 램덤 씨퀀싱에 의해 결정된 fl-383d 클론의 염기서열과 컴퓨터 프로그램을 이용하여 상기 클론과 유사성을 갖는 유전자를 검색한 결과이며, 제2도는 fl-383d 클론의 전체 염기서열 및 이로부터 유추한 아미노산 서열을 나타낸 것이다, 제3도는 아미노산 수준에서 fl-383d 클론과 A1 유전자를 비교한 것이다.

Claims (2)

  1. 하기의 염기배열 전체 또는 그 일부로 구성된 아폽토시스 조절 유전자.
  2. 제1항의 아폽토시스 조절 유전자 클론에 의해 형질전환된 E.coli(383-E.coli)(기탁번호 KCCM10061).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950006266A 1995-03-24 1995-03-24 아폽토시스 조절 유전자 KR960034413A (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR1019950006266A KR960034413A (ko) 1995-03-24 1995-03-24 아폽토시스 조절 유전자
EP96907773A EP0759075B1 (en) 1995-03-24 1996-03-25 Apoptosis regulating gene
DE69634939T DE69634939D1 (de) 1995-03-24 1996-03-25 Apoptose regulierendes gen
PCT/KR1996/000040 WO1996030513A1 (en) 1995-03-24 1996-03-25 Apoptosis regulating gene
JP8529196A JPH10504975A (ja) 1995-03-24 1996-03-25 アポプトシス調節遺伝子
KR1019960008132A KR100302057B1 (ko) 1995-03-24 1996-03-25 아폽토시스조절유전자
US08/737,980 US5843773A (en) 1995-03-24 1996-03-25 Apoptosis regulating gene
CA002191214A CA2191214A1 (en) 1995-03-24 1996-03-25 Apoptosis regulating gene

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950006266A KR960034413A (ko) 1995-03-24 1995-03-24 아폽토시스 조절 유전자

Publications (1)

Publication Number Publication Date
KR960034413A true KR960034413A (ko) 1996-10-22

Family

ID=19410458

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019950006266A KR960034413A (ko) 1995-03-24 1995-03-24 아폽토시스 조절 유전자
KR1019960008132A KR100302057B1 (ko) 1995-03-24 1996-03-25 아폽토시스조절유전자

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019960008132A KR100302057B1 (ko) 1995-03-24 1996-03-25 아폽토시스조절유전자

Country Status (7)

Country Link
US (1) US5843773A (ko)
EP (1) EP0759075B1 (ko)
JP (1) JPH10504975A (ko)
KR (2) KR960034413A (ko)
CA (1) CA2191214A1 (ko)
DE (1) DE69634939D1 (ko)
WO (1) WO1996030513A1 (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100426457B1 (ko) * 2001-09-18 2004-04-14 김진우 인간 암 억제 유전자, 이에 의해 코딩되는 단백질, 이를포함하는 발현 벡터 및 이 벡터로 형질전환된 세포
KR100434591B1 (ko) * 2002-04-16 2004-06-04 김진우 인간 암 억제 유전자, 이에 의해 코딩되는 단백질, 이를포함하는 발현 벡터 및 이 벡터로 형질전환된 세포

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001992A (en) * 1999-01-07 1999-12-14 Isis Pharmaceuticals Inc. Antisense modulation of novel anti-apoptotic bcl-2-related proteins
US7157098B1 (en) * 1998-01-06 2007-01-02 Roman Perez-Soler Gene therapy of tumors using non-viral delivery system
US6221600B1 (en) * 1999-10-08 2001-04-24 Board Of Regents, The University Of Texas System Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
KR100426455B1 (ko) * 2000-04-25 2004-04-13 김진우 인간 암 억제 유전자, 이에 의해 코딩되는 단백질, 이를포함하는 발현 벡터 및 이 벡터로 형질전환된 세포
US6465187B1 (en) 2000-05-08 2002-10-15 Innoventus Project Ab Method of treatment
US7115370B2 (en) 2002-06-05 2006-10-03 Capital Genomix, Inc. Combinatorial oligonucleotide PCR
KR100577512B1 (ko) * 2003-06-16 2006-05-10 주식회사 바이오인프라 녹색 형광 단백질과 Ｂｆｌ-1의 융합단백질 또는 이를코딩하는 유전자를 포함하는 세포사멸을 유도하기 위한약학 조성물
US9505821B2 (en) 2006-10-03 2016-11-29 Rutgers, The State University Of New Jersey ATAP peptides, nucleic acids encoding the same and associated methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889806A (en) * 1987-04-15 1989-12-26 Washington University Large DNA cloning system based on yeast artificial chromosomes
EP0633934A1 (en) * 1992-04-02 1995-01-18 Imperial Cancer Research Technology Limited Modified cells and method of treatment

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100426457B1 (ko) * 2001-09-18 2004-04-14 김진우 인간 암 억제 유전자, 이에 의해 코딩되는 단백질, 이를포함하는 발현 벡터 및 이 벡터로 형질전환된 세포
KR100434591B1 (ko) * 2002-04-16 2004-06-04 김진우 인간 암 억제 유전자, 이에 의해 코딩되는 단백질, 이를포함하는 발현 벡터 및 이 벡터로 형질전환된 세포

Also Published As

Publication number Publication date
EP0759075B1 (en) 2005-07-20
KR100302057B1 (ko) 2001-10-22
WO1996030513A1 (en) 1996-10-03
JPH10504975A (ja) 1998-05-19
US5843773A (en) 1998-12-01
EP0759075A1 (en) 1997-02-26
KR960034416A (ko) 1996-10-22
CA2191214A1 (en) 1996-10-03
DE69634939D1 (de) 2005-08-25

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