KR960033482A - 방사성 팻치/필름 및 그의 제조방법 - Google Patents

방사성 팻치/필름 및 그의 제조방법 Download PDF

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Publication number
KR960033482A
KR960033482A KR1019960005322A KR19960005322A KR960033482A KR 960033482 A KR960033482 A KR 960033482A KR 1019960005322 A KR1019960005322 A KR 1019960005322A KR 19960005322 A KR19960005322 A KR 19960005322A KR 960033482 A KR960033482 A KR 960033482A
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South Korea
Prior art keywords
film
patch
radioactive
particles
radionuclide
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KR1019960005322A
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English (en)
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KR0170811B1 (ko
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박경배
김재록
이종두
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신재인
한국원자력연구소
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Priority claimed from KR1019950004642A external-priority patent/KR960033481A/ko
Application filed by 신재인, 한국원자력연구소 filed Critical 신재인
Priority to KR1019960005322A priority Critical patent/KR0170811B1/ko
Priority to ES96400477T priority patent/ES2161987T3/es
Priority to DE69614422T priority patent/DE69614422T2/de
Priority to CA002171124A priority patent/CA2171124C/en
Priority to AU47914/96A priority patent/AU685351B2/en
Priority to EP96400477A priority patent/EP0730873B1/en
Priority to US08/610,554 priority patent/US5871708A/en
Priority to AT96400477T priority patent/ATE204181T1/de
Publication of KR960033482A publication Critical patent/KR960033482A/ko
Publication of KR0170811B1 publication Critical patent/KR0170811B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1279—Plasters, bandages, dressings, patches or adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1028—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy using radiation sources applied onto the body
    • A61N5/1029—Radioactive dressings

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 방사성 팻치/필름 및 그의 제조방법에 관한 것이다. 방사성 물질을 팻치/필름 형태로 하여 피부에 접착시켜 직접 피부에 방사선을 조사하게 되어 있는 방사성 팻치/필름은 안정 핵종을 함유하는 다양한 형태의 안정 팻치/필름을 만든 중성자 조사하여 제조하는 것으로서 각종 암 및 피부질환 치료에 효과적이다.

Description

방사성 팻치/필름 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에 의해 제조한166Ho-방사성 팻치,
제2도는 본 발명의 방사성 팻치에 의한 종양 치유의 효과 1) 치료전 백서에서 피부암이 발생된 모습, 2)166Ho-방사성 팻치를 피부암 부위에 부착한 모습, 3) 치료일주일 후 피부암이 소실된 모습.

Claims (15)

  1. 치료용 방사선을 방출하는 방사성 핵종이 포함된 것을 특징으로 하는 방사성 팻치/필름.
  2. 제1항에 있어서, 치료용 방사선을 방출하는 방사성 핵종의 입자와 기제가 혼합된 층, 이것을 지지하는 지지층 그리고 라미네이트층으로 구성된 것을 특징으로 하는 방사성 팻치
  3. 제1항에 있어서, 치료용 방사선을 방출하는 방사성 핵종과 기제가 혼합된 층과 라미네이트층으로 구성된 것을 특징으로 하는 방사성 필름.
  4. 제2항 또는 제3항에 있어서, 방사성 핵종은 β-선 방출 핵종 또는 γ-선 방출핵종인 것을 특징으로 하는 방사성 팻치/필름.
  5. 제4항에 있어서, β-선 방출 핵종 또는153Sm,165Dy,166Ho,32P,90Y 또는169Er 중에서 선택되어지는 것을 특징으로 하는 방사성 팻치/필름.
  6. 제4항에 있어서, γ-선 방출핵종은 또는192Ir인 것을 특징으로 하는 방사성 팻치/필름.
  7. 1) 안정 핵종의 입자를 기제와 혼합한 후 기지제에 도포하여 팻치를 제조하는 단계, 2) 팻치를 얇은 막으로 라미네이션하여 밀봉하는 단계, 3) 밀봉된 팻치를 원자로에서 중성자 조사하여 방사선을 방출하는 방사성 팻치를 제조하는 단계로 구성되는 것을 특징으로 하는 제1항의 방사성 팻치의 제조방법.
  8. 제7항에 있어서, 안정핵종의 입자는165Ho 화합물의 입자,164Dr 화합물의 입자,89Y2O3입자,31P 입자,191Ir 화합물의 입자로 구성되는 군에서 선택되어지는 것을 특징으로 하는 방사성 팻치의 제조방법.
  9. 제7항 또는 제8항에 있어서, 안정 핵종의 입자의 크기는 1~10㎛인 것을 특징으로 하는 방사성 팻치의 제조방법.
  10. 1) 안정 핵종의 용액과 기제를 용매에 녹인 용액을 혼합하여 얇은 막을 만든 후 건조시켜 필름을 만드는 단계, 2) 필름을 얇은 막으로 라미네이션하여 밀봉하는 단계, 3) 밀봉된 필름을 원자로에서 중성자 조사하여 방사선을 방출하는 방사성 필름을 제조하는 단계로 구성하는 것을 특징으로 하는 방사성 팻치의 제조방법.
  11. 제10항에 있어서, 안정핵종의 용액은165Ho(No3)3, 또는164Dy(No3)3를 녹인 것을 특징으로 하는 방사성 팻치의 제조방법.
  12. 제7항 또는 제10항에 있어서, 라미네이션하는 막은 폴리에틸렌인 것을 특징으로 하는 방사성 팻치 필름의 제조방법.
  13. 제1항의 방사성 팻치/필름의 암 치료제로서의 용도.
  14. 제1항의 방사성 팻치/필름의 피부 질환 치료제로서의 용도.
  15. 제12항에 있어서, 피부 질환은 각종 피부암, 무좀, 켈로이드(Keloid)를 포함하는 것을 특징으로 하는 피부 질환 치료제로서의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960005322A 1995-03-07 1996-02-29 방사성 팻치/필름 및 그의 제조방법 KR0170811B1 (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR1019960005322A KR0170811B1 (ko) 1995-03-07 1996-02-29 방사성 팻치/필름 및 그의 제조방법
AU47914/96A AU685351B2 (en) 1995-03-07 1996-03-06 A radioactive patch/film and process for preparation thereof
DE69614422T DE69614422T2 (de) 1995-03-07 1996-03-06 Ein radioaktives Pflaster/Film und Verfahren zu seiner Herstellung
CA002171124A CA2171124C (en) 1995-03-07 1996-03-06 A radioactive patch/film and process for preparation thereof
ES96400477T ES2161987T3 (es) 1995-03-07 1996-03-06 Parche/pelicula radioactiva y procedimiento para la preparacion de la misma.
EP96400477A EP0730873B1 (en) 1995-03-07 1996-03-06 A radioactive patch/film and process for preparation thereof
US08/610,554 US5871708A (en) 1995-03-07 1996-03-06 Radioactive patch/film and process for preparation thereof
AT96400477T ATE204181T1 (de) 1995-03-07 1996-03-06 Ein radioaktives pflaster/film und verfahren zu seiner herstellung

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1019950004642A KR960033481A (ko) 1995-03-07 1995-03-07 피부질환 치료용 방사성팻취와 그 제조방법
KR101995004642 1995-03-07
KR95-4642 1995-03-07
KR1019960005322A KR0170811B1 (ko) 1995-03-07 1996-02-29 방사성 팻치/필름 및 그의 제조방법

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KR960033482A true KR960033482A (ko) 1996-10-22
KR0170811B1 KR0170811B1 (ko) 1999-03-20

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KR1019960005322A KR0170811B1 (ko) 1995-03-07 1996-02-29 방사성 팻치/필름 및 그의 제조방법

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EP (1) EP0730873B1 (ko)
KR (1) KR0170811B1 (ko)
AT (1) ATE204181T1 (ko)
AU (1) AU685351B2 (ko)
CA (1) CA2171124C (ko)
DE (1) DE69614422T2 (ko)
ES (1) ES2161987T3 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006031038A1 (en) * 2004-09-15 2006-03-23 Dong Wha Pharm. Ind. Co., Ltd. A method for preparing radioactive film

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Publication number Priority date Publication date Assignee Title
US7048907B2 (en) 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
FR2930890B1 (fr) * 2008-05-06 2010-12-10 Univ Claude Bernard Lyon Nouveaux agents de radiotherapie ciblee ou de curietherapie a base d'oxydes ou d'oxo-hydroxydes de terre rare
DE102018119745A1 (de) * 2018-08-14 2020-02-20 Axel Boese Patch mit aktiven Inhaltsstoffen
CN115475323B (zh) * 2022-09-16 2024-05-24 武汉市中心医院 基于3d打印的核素敷贴及制备方法
CN117067796B (zh) * 2023-10-17 2024-01-16 原子高科股份有限公司 放射性核素敷贴器的制作方法、系统、敷贴器及电子设备

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BE514504A (ko) *
GB253207A (en) * 1925-03-13 1926-06-14 Axel Rudolf Blomberg Radio-active compresses and a preparation for use in the manufacture thereof
GB704628A (en) * 1951-02-24 1954-02-24 Chininfabrik Braunschweig Buch Improvements in plastic radiation-applicators
FR1458937A (fr) * 1964-11-09 1966-04-29 Commissariat Energie Atomique Procédé de préparation du citrate d'yttrium colloïdal
JPS6016921A (ja) * 1983-07-09 1985-01-28 Nobuharu Irie 貼付薬
US4789501A (en) * 1984-11-19 1988-12-06 The Curators Of The University Of Missouri Glass microspheres
JPS61293463A (ja) * 1985-06-24 1986-12-24 株式会社　高純度化学研究所 治療用具
US4946435A (en) * 1988-10-24 1990-08-07 Best Industries, Inc. Flexible sealed radioactive film for radiotherapy, and method of making same
DE4132925A1 (de) * 1991-10-04 1993-04-08 Birg Walter Medizinisches pflaster mit strahlenschutzwirkung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006031038A1 (en) * 2004-09-15 2006-03-23 Dong Wha Pharm. Ind. Co., Ltd. A method for preparing radioactive film

Also Published As

Publication number Publication date
EP0730873A1 (en) 1996-09-11
EP0730873B1 (en) 2001-08-16
DE69614422T2 (de) 2002-05-16
ATE204181T1 (de) 2001-09-15
KR0170811B1 (ko) 1999-03-20
ES2161987T3 (es) 2001-12-16
CA2171124A1 (en) 1996-09-08
AU4791496A (en) 1996-09-19
DE69614422D1 (de) 2001-09-20
AU685351B2 (en) 1998-01-15
CA2171124C (en) 2001-01-30

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