KR960029329A - Improved Process for the Preparation of Methyl 3-methoxy-4,5-methylenedioxybenzoate - Google Patents

Improved Process for the Preparation of Methyl 3-methoxy-4,5-methylenedioxybenzoate Download PDF

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Publication number
KR960029329A
KR960029329A KR1019950001186A KR19950001186A KR960029329A KR 960029329 A KR960029329 A KR 960029329A KR 1019950001186 A KR1019950001186 A KR 1019950001186A KR 19950001186 A KR19950001186 A KR 19950001186A KR 960029329 A KR960029329 A KR 960029329A
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KR
South Korea
Prior art keywords
methoxy
methyl
methylenedioxybenzoate
preparation
general formula
Prior art date
Application number
KR1019950001186A
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Korean (ko)
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KR0146501B1 (en
Inventor
조의환
정순간
김중영
김병철
Original Assignee
최승주
삼진제약 주식회사
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Application filed by 최승주, 삼진제약 주식회사 filed Critical 최승주
Priority to KR1019950001186A priority Critical patent/KR0146501B1/en
Publication of KR960029329A publication Critical patent/KR960029329A/en
Application granted granted Critical
Publication of KR0146501B1 publication Critical patent/KR0146501B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms

Abstract

본 발명은 간장치료제로 유용하게 사용되는 디메틸 4,4'-디메톡시-5,6,5',6'-디메틸렌디옥시비페닐-2,2'-디카르복실레이트(DDB)의 제조중간체로 사용되는, 아래 일반구조식 (Ⅳ)의 메틸 3-메톡시-4.5-메틸렌디옥시벤조에이트의 개량된 제조방법에 관한 것으로, 일반식(Ⅲ)의 메틸 3-메톡시-4.5-디하이드록시벤조에이트에 메틸렌 디클로라이드를 반응시킴에 있어서, 디메틸포름 아미드 존재하에서 세슘카보네이트와 반응시키는 것을 특징으로 하는 일반식(Ⅳ)의 메틸 3-메톡시-4.5-메틸렌디옥시벤조에이트를 제조하는 새로운 방법을 제공한다.The present invention provides the preparation of dimethyl 4,4'-dimethoxy-5,6,5 ', 6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) which is usefully used as an intercalating agent. A modified process for the preparation of methyl 3-methoxy-4.5-methylenedioxybenzoate of the general formula (IV) below, which is used as an intermediate, relates to methyl 3-methoxy-4.5-dihydride of the general formula (III) In preparing methylene 3-methoxy-4.5-methylenedioxybenzoate of the general formula (IV), the reaction of methylene dichloride with oxybenzoate is carried out with cesium carbonate in the presence of dimethylformamide. Provide a method.

→ →

(Ⅲ) (Ⅳ)(Ⅲ) (Ⅳ)

본 발명의 방법은 종래의 방법에 비하여 그 수율이 월등하며, 반응이 간단히 신속하게 수행된다.The method of the present invention is superior in yield to the conventional method, and the reaction is carried out simply and quickly.

Description

메틸 3-메톡시-4.5-메틸렌디옥시벤조에이트의 개량된 제조방법Improved Process for the Preparation of Methyl 3-methoxy-4.5-methylenedioxybenzoate

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

일반식(Ⅲ)의 메틸 3-메톡시-4.5-디하이드록시벤조에이트에 메틸렌 디클로라이드를 반응시킴에 있어서, 디메틸포름 아미드 존재하에서 세슘카보네이트와 반응시키는 것을 특징으로 하는 일반식(Ⅳ)의 메틸 3-메톡시-4.5-메틸렌디옥시벤조에이트를 제조하는 방법.In the reaction of methylene dichloride with methyl 3-methoxy-4.5-dihydroxybenzoate of formula (III), methyl of formula (IV) characterized by reacting with cesium carbonate in the presence of dimethylformamide. Process for preparing 3-methoxy-4.5-methylenedioxybenzoate. → → (Ⅲ) (Ⅳ)(Ⅲ) (Ⅳ) 제1항에 있어서, 세슘카보네이트의 양을 0.5~5당량을 사용하는 방법.The method according to claim 1, wherein the amount of cesium carbonate is used in 0.5 to 5 equivalents. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950001186A 1995-01-24 1995-01-24 Improved production of methyl-3-methoxy-4,5-methylene dioxybenzoate KR0146501B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950001186A KR0146501B1 (en) 1995-01-24 1995-01-24 Improved production of methyl-3-methoxy-4,5-methylene dioxybenzoate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950001186A KR0146501B1 (en) 1995-01-24 1995-01-24 Improved production of methyl-3-methoxy-4,5-methylene dioxybenzoate

Publications (2)

Publication Number Publication Date
KR960029329A true KR960029329A (en) 1996-08-17
KR0146501B1 KR0146501B1 (en) 1998-08-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950001186A KR0146501B1 (en) 1995-01-24 1995-01-24 Improved production of methyl-3-methoxy-4,5-methylene dioxybenzoate

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KR0146501B1 (en) 1998-08-17

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