KR960021049A - Manufacturing method of herbal extract and extract dry powder with excellent free radical scavenging ability - Google Patents

Manufacturing method of herbal extract and extract dry powder with excellent free radical scavenging ability Download PDF

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Publication number
KR960021049A
KR960021049A KR1019940039672A KR19940039672A KR960021049A KR 960021049 A KR960021049 A KR 960021049A KR 1019940039672 A KR1019940039672 A KR 1019940039672A KR 19940039672 A KR19940039672 A KR 19940039672A KR 960021049 A KR960021049 A KR 960021049A
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KR
South Korea
Prior art keywords
extract
weight
free radical
peony
bokbunja
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KR1019940039672A
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Korean (ko)
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KR0141650B1 (en
Inventor
김희선
이병순
방성모
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한동근
주식회사 태평양
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Priority to KR1019940039672A priority Critical patent/KR0141650B1/en
Publication of KR960021049A publication Critical patent/KR960021049A/en
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Publication of KR0141650B1 publication Critical patent/KR0141650B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

본 발명은 특정의 생약재로부터 유리기 소거활성이 뛰어난 엑기스 및 엑기스 건조분말을 제조하는 방법을 제공한다. 본 발명의 방법에 따라 사용되는 생약재는 복분자, 삼백초 및 작약이며, 본 발명의 방법은 이들 생약재를 분쇄하여 얻은 각 분쇄물에 30∼95중량%의 수성 에탄올을 5∼8배량 가하여 50∼90℃에서 2∼5시간씩 2∼3회 추출하여 추출액을 얻고; 추출액을 수욕조 온도 50∼90℃, 진공 60∼76cmHg 의 건조하에서 감압 농축하여 고형분 농도 5∼60중량%의 엑기스를 제조하거나; 필요에 따라 동결건조하여 엑기스 건조분말을 수득함을 특징으로 한다.The present invention provides a method for producing extracts and extract dry powders having excellent free radical scavenging activity from certain herbal medicines. The herbal medicines used according to the method of the present invention are bokbunja, three hundred seconds and peony, the method of the present invention is 50 to 90 ℃ by adding 5 to 8 times 30 to 95% by weight of aqueous ethanol to each ground product obtained by grinding these herbal medicines Extract 2 to 3 times at 2 to 5 hours in to obtain an extract; The extract was concentrated under reduced pressure under a water bath temperature of 50 to 90 ° C. under vacuum of 60 to 76 cmHg to prepare an extract having a solid content of 5 to 60% by weight; Lyophilization as needed, characterized in that the extract is dried powder.

본 발명의 특정 조건하에서 얻어진 상기 생약재의 엑기스 또는 엑기스 건조분말을 우수한 유리기 소거활성을 나타낸다.The extract or extract dried powder of the herbal medicine obtained under the specific conditions of the present invention shows excellent free radical scavenging activity.

Description

유리기(遊離基) 소거 능력이 우수한 생약제 엑기스 및 엑기스 건조분말의 제조방법Method for manufacturing herbal extract and extract dry powder with excellent free radical scavenging ability

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (5)

복분자, 작약 또는 삼백초의 엑기스를 제조하는 방법에 있어서, 이들 복분자, 작약 또는 삼백초의 분쇄물에 30~95중량% 수성 에탄올을 5~8배량 가하여 50~90℃에서 2~5시간씩 2~3회 추출하여 추출액을 얻고; 추출액을 수욕조 온도 50~90℃, 진공 60~76cmHg의 건조하에서 감압 농축하여 고형분 농도 5~60중량%의 엑기스를 제조하거나; 필요에 따라 동결건조하여 엑기스 건조분말을 수득함을 특징으로 하는 복분자, 작약 또는 삼백초의 엑기스 또는 엑기스 건조분말의 제조방법.In the method of manufacturing Bokbunja, Peony or 300 seconds extract, 5-8 times of 30 ~ 95% by weight aqueous ethanol is added to these bokbunja, Peony or 300 seconds crushed powder at 2 ~ 3 hours at 50 ~ 90 ℃. Extract once to obtain an extract; The extract was concentrated under reduced pressure under a water bath temperature of 50-90 ° C. under vacuum drying of 60-76 cmHg to prepare an extract having a solid concentration of 5-60 wt%; A method for producing bokbunja, peony or extract of 300 seconds or extract dried powder, which is obtained by freeze-drying as necessary to obtain extract dried powder. 제1항에 있어서, 동결건조는, 고형분 농도 30~60중량%의 엑기스를 -10~50℃에서 냉동시키고, 이것을 동결건조 온도 -50℃, 진공 0.1~5micronsHg로 하여 수분함량이 10중량% 이하가 되도록 건조함을 특징으로 하는 제조방법.The freeze drying according to claim 1, wherein the extract having a solid content concentration of 30 to 60% by weight is frozen at -10 to 50 ° C, and the freeze-drying temperature is -50 ° C and a vacuum of 0.1 to 5 micronsHg, and the moisture content is 10% by weight or less. Manufacturing method characterized in that the drying to be. 제1항에 있어서, 추출단계에서 복분자는 30~50중량%의 수성 에탄올을 이용하여 50~90℃에서 약 4시간씩 추출함을 특징으로 하는 제조방법.The method according to claim 1, wherein in the extraction step, the bokbunja are extracted at about 50 hours at 50 to 90 ° C. using 30 to 50% by weight of aqueous ethanol. 제1항에 있어서, 추출단계에서 삼백초는 30~70중량%의 수성 에탄올을 이용하여 50~90℃에서 약 4시간씩 추출함을 특징으로 하는 제조방법.The method according to claim 1, wherein in the extracting step, 300 seconds is extracted by using about 30 to 70% by weight of aqueous ethanol at about 4 hours at 50 to 90 ° C. 제1항에 있어서, 추출단계에서 작약은 70~90중량%의 수성 에탄올을 이용하여 70~90℃에서 약 4시간씩 추출함을 특징으로 하는 제조방법.The method of claim 1, wherein in the extraction step, the peony is extracted by using 70 to 90% by weight of aqueous ethanol at about 70 to 90 ° C for about 4 hours. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940039672A 1994-12-30 1994-12-30 Extracts crude drug whc KR0141650B1 (en)

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Application Number Priority Date Filing Date Title
KR1019940039672A KR0141650B1 (en) 1994-12-30 1994-12-30 Extracts crude drug whc

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Application Number Priority Date Filing Date Title
KR1019940039672A KR0141650B1 (en) 1994-12-30 1994-12-30 Extracts crude drug whc

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KR960021049A true KR960021049A (en) 1996-07-18
KR0141650B1 KR0141650B1 (en) 1998-06-01

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960021001A (en) * 1994-12-21 1996-07-18 성재갑 Radical scavengers made from three hundred s. Extracts, their extraction methods and anti-aging cosmetics containing them
KR20020008608A (en) * 2000-07-24 2002-01-31 임명호 Method of making wild field-berry wine

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